The 49ers will play the Colts on Monday, December 22nd, 2025. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 16 matchup at 8:15 pm EST. Check local listings for coverage on ESPN, ABC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 16, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the San Francisco 49ers and Indianapolis Colts. They'll play on Monday, December 22nd, 2025 at Lucas Oil Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 16 of the 2025-26 NFL regular season, the San Francisco 49ers have a 94.67 power ranking based on our formula. Their opponent, the Indianapolis Colts, currently possess a 93.67 power ranking.
- Away San Francisco 49ers - With the season coming to a close, the San Francisco 49ers have a 6-2-0 record as an away team, ranking them 1st in the league for away team wins.
- Home Indianapolis Colts - The Indianapolis Colts come to this Week 16 game with a 6-1-0 record as a home team. They rank 2nd in the league for home team wins as the 2025-26 regular season wraps up.
- Points Scored - The San Francisco 49ers currently rank 11th (344) headed into Week 16, with the Indianapolis Colts ranked 6th (392) for points scored to date.
- Points Against - As the regular season winds down, the San Francisco 49ers rank 20th (293) for points score against them. Note that the Indianapolis Colts now rank 19th (303) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 16, the San Francisco 49ers have a 10-4-0 record, with the Indianapolis Colts at 8-6-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr, me hearties! The San Francisco 49ers be facin' off against the Indianapolis Colts. This be an important Week 16 matchup as the NFL regular season be nearin' its end. The result o' this game may affect the NFL playoff picture greatly.
The San Francisco 49ers be standin' at 10-4-0, while the Indianapolis Colts be at 8-6-0. The 49ers lead their NFC West Division with a 4-1-0 standing. The Colts be holdin' a 2-2-0 standing in the AFC South Division.
This Week 16 showdown be happenin' at Lucas Oil Stadium. The SportsBetting3.com NFL Power Rankings show the 49ers at 94.67 and the Colts at 93.67. Place a bet at BetRivers or BetMGM and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks for ye to plunder!
Best 49ers at Colts Odds
| Underdog Indianapolis Colts | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Indianapolis Colts | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -4.5 -105 point spread favorites at BetMGM, while the Indianapolis Colts are +4.5 -115 point spread underdogs at BetMGM.
The best over line is 46.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 46.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -220 moneyline favorite at BetMGM and the Indianapolis Colts are the +185 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Colts
12/22/25 8:15pm EST | -4.5 -105+4.5 -115 |
Underdog Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $86.96 at -115 odds.
A +4.5 Indianapolis Colts underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $95.24 at -105 odds.
A -4.5 San Francisco 49ers favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.
San Francisco 49ers at Indianapolis Colts Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Colts
First Team To Score
12/22/25 8:15pm EST | -125-102Bet |
49ers
Colts
No Touchdown
To Score 1st Touchdown
12/22/25 8:15pm EST | -140+105+10000Bet |
49ers
Colts
Game to Overtime
12/22/25 8:15pm EST | Yes +750No -2500Bet |
49ers
Colts
Safety to be Scored
12/22/25 8:15pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
SF at IND 12/22/25 8:15pm EST | 0.5 o -1400.5 u +105Bet |
Philip Rivers
Interceptions Thrown
SF at IND 12/22/25 8:15pm EST | 0.5 o -1050.5 u -125Bet |
Brock Purdy
Longest Passing Completion
SF at IND 12/22/25 8:15pm EST | 34.5 o -11034.5 u -118Bet |
Philip Rivers
Longest Passing Completion
SF at IND 12/22/25 8:15pm EST | 27.5 o -11527.5 u -115Bet |
| BetMGM | |
Blake Grupe
Total Kicking Points
SF at IND 12/22/25 8:15pm EST | 6.5 o -1106.5 u -118Bet |
Eddy Pineiro
Total Kicking Points
SF at IND 12/22/25 8:15pm EST | 7.5 o -1157.5 u -115Bet |
Brock Purdy
Total Pass Completions
SF at IND 12/22/25 8:15pm EST | 21.5 o -13521.5 u +100Bet |
Philip Rivers
Total Pass Completions
SF at IND 12/22/25 8:15pm EST | 17.5 o -13517.5 u +105Bet |
| BetMGM | |
Brock Purdy
Total Passing Yards
SF at IND 12/22/25 8:15pm EST | 245.5 o -115245.5 u -115Bet |
Philip Rivers
Total Passing Yards
SF at IND 12/22/25 8:15pm EST | 160.5 o -135160.5 u +100Bet |
Brock Purdy
Total Touchdown Passes
SF at IND 12/22/25 8:15pm EST | 1.5 o -1551.5 u +115Bet |
Philip Rivers
Total Touchdown Passes
SF at IND 12/22/25 8:15pm EST | 0.5 o -1900.5 u +140Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 16 | 49ers vs Colts Monday, December 22nd, 2025 | SF 48, IND 27 Lucas Oil Stadium | 49ers by 21 |
| 2021 Week 7 | Colts vs 49ers Sunday, October 24th, 2021 | IND 30, SF 18 Levi's Stadium | Colts by 12 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - San Francisco 49ers | 12 | 5 | 0 | 0.706 | 437 | 371 | 5-3-0 | 7-2-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1L | 4-1-0 |
| Indianapolis Colts | 8 | 9 | 0 | 0.471 | 466 | 412 | 6-3-0 | 2-6-0 | 2-4-0 | 0.333 | 6-6-0 | 0.500 | 7L | 0-5-0 |
San Francisco 49ers & Indianapolis Colts Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
No Super Bowl TM Indianapolis Colts YR: futures available
San Francisco 49ers & Indianapolis Colts Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Indianapolis Colts NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Monday, December 22nd, 2025 at 8:15 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Indianapolis Colts Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Indianapolis Colts Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.