San Francisco 49ers fans, will the Niners bring home a Super Bowl trophy this season? We’ve got the latest 49ers betting odds, futures odds, and season win total odds. Next, we included a quick primer on how to bet on the San Francisco 49ers. Combine point spreads, over-under totals, and moneyline bets with your own NFL handicapping to get an edge.
We also have San Francisco’s recent standings, odds to make the playoffs, odds to win the most regular season games, and this season’s schedule and results. Use this information to help you make informed wagers when the San Francisco 49ers face key opponents this season.
Table of Contents
- Betting Sites
- Game Odds
- Prop Bets
- Win Total Odds
- Odds to Make Playoffs
- Super Bowl Odds
- Conference Odds
- Division Odds
- To Win Most Games
- Matchup Results
- Standings
Best San Francisco 49ers Sports Betting Sites
| Bonus | |
|---|---|
 #1 BetMGMREVIEW | PA *New* Customers - Bet $10, Get $150 in Bonus Bets If You Win Thru 6/2/2025 - Bonus Bets Expire in 7 Days One new customer offer/Add'l Terms Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
 #2 BetRiversREVIEW | New Customers - 2nd Chance Bet up to $500 - Code: SPORTS Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
San Francisco 49ers Game Odds
Point spread, total, and moneyline odds for upcoming San Francisco 49ers matchups from licensed and regulated US sports betting sites. We explain how to place each bet below.
Markets|
Game |
 BetMGMBet |
 BetRiversBet |
|---|
San Francisco 49ers Prop Bets
Review prop bets for the next San Francisco 49ers matchup. Will a safety be scored? Will the game go to overtime? How will the quarterback and kicker perform? Will the 49ers team point total be over or under the sportsbook’s line?
| BetMGM Bet |
|
|---|---|
49ers
Seahawks
9/07/25 7:05pm EDT | Pending BetMGM |
San Francisco 49ers Win Total Odds
The season win total is part prop, part future hybrid. The plus and minus values assign odds to either side of the team’s win total line. This bet functions like a total bet. Bet either over or under the sportsbook’s line.
| BetMGM Bet |
|
|---|---|
49ers
2025-26 Season Win Total |
San Francisco 49ers Odds to Make Playoffs
Bet “Yes” if you think a team will make the playoffs this season, or “No” if you think they won’t. Like the season win total, this bet is part prop, part future. With futures, you can only bet on the San Francisco 49ers to win a particular event. But with the odds to make the playoffs bet, you can bet either “Yes” or “No” on the San Francisco 49ers to make the playoffs.
| BetMGM Bet |
|
|---|---|
49ers
2024-25 To Make Playoffs |
San Francisco 49ers Super Bowl Odds
Here are the 49ers’ odds to win the Super Bowl. SportsBetting3.com Super Bowl odds update daily. It doesn’t always pay to bet early. You want to bet San Francisco as soon as their odds of winning become favorable, but not too late that the payout will be low. Learn more about how to place futures bets with our helpful tutorial.
|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
San Francisco 49ers Odds to win the NFC
Review the San Francisco 49ers’ odds to win the NFC. Conference futures odds update 2-3 times per week throughout the season.
|
Team | BetMGM |
BetRivers |
|---|---|---|
| 49ers | +800 Bet | +700 Bet |
San Francisco 49ers Odds to win the NFC West
Here are the San Francisco 49ers’ odds to win the NFC West. Like the conference futures, odds to win each division update 2-3 times per week throughout the season.
|
Team | BetRivers |
|---|---|
| 49ers | +150 Bet |
San Francisco 49ers Odds to win the Most Regular Season Games
Bet on San Francisco if you think the 49ers will win the most regular season games. This bet requires a team to win more games than any other, with any ties broken by the sportsbook’s wagering rules. If you think San Francisco can win at least half their games, then they would be in the running to win the most regular season games. Unlike other futures bets for a particular event, this bet is based on a team’s performance relative to others over the course of the regular season.
|
Team | BetMGM |
|---|---|
| 49ers | +1500 Bet |
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San Francisco 49ers Schedule and Results
Review the 49ers’ recent schedule and game results from the preseason, regular season, and postseason. Be sure to check out your sportsbook’s NFL promotions during the postseason. Many sports betting sites will offer bonus codes for teams that make the playoffs.
2025-26 San Francisco 49ers Games & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Preseason 2 | 49ers vs Raiders | Saturday, August 16th, 2025 4:00 pm EDT |
| Week 1 | 49ers vs Seahawks | Sunday, September 7th, 2025 4:05 pm EDT |
| Week 2 | 49ers vs Saints | Sunday, September 14th, 2025 1:00 pm EDT |
| Week 3 | Cardinals vs 49ers | Sunday, September 21st, 2025 4:25 pm EDT |
| Week 4 | Jaguars vs 49ers | Sunday, September 28th, 2025 4:05 pm EDT |
| Week 5 | 49ers vs Rams | Thursday, October 2nd, 2025 8:15 pm EDT |
| Week 6 | 49ers vs Buccaneers | Sunday, October 12th, 2025 1:00 pm EDT |
| Week 7 | Falcons vs 49ers | Sunday, October 19th, 2025 8:20 pm EDT |
| Week 8 | 49ers vs Texans | Sunday, October 26th, 2025 1:00 pm EDT |
| Week 9 | 49ers vs Giants | Sunday, November 2nd, 2025 1:00 pm EST |
| Week 10 | Rams vs 49ers | Sunday, November 9th, 2025 4:25 pm EST |
| Week 11 | 49ers vs Cardinals | Sunday, November 16th, 2025 4:05 pm EST |
| Week 12 | Panthers vs 49ers | Monday, November 24th, 2025 8:15 pm EST |
| Week 13 | 49ers vs Browns | Sunday, November 30th, 2025 1:00 pm EST |
| Week 14 | 49ers Bye Week | |
| Week 15 | Titans vs 49ers | Sunday, December 14th, 2025 4:25 pm EST |
| Week 16 | 49ers vs Colts | Monday, December 22nd, 2025 8:15 pm EST |
| Week 17 | Bears vs 49ers | Sunday, December 28th, 2025 8:20 pm EST |
| Week 18 | Seahawks vs 49ers | Sunday, January 4th, 2026 12:00 am EST |
How to Bet on the San Francisco 49ers
Time needed: 2 minutes.
How to Bet on the San Francisco 49ers
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Open a new sports betting account.
Review our list of NFL betting sites. Each sportsbook offers many ways to bet on the San Francisco 49ers. Make sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming San Francisco 49ers matchups. Review any San Francisco 49ers futures odds.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the San Francisco 49ers bet has been graded.
Point Spread Bets
The San Francisco 49ers will be favorites when their point spread line has a minus sign “-” before the number. They’ll be underdogs when the line has a plus sign “+” before the number.
The odds follow the point spread line. Standard betting odds are -110. That means you’ll risk $110 to win $100. Sometimes, the odds might be higher or lower depending on the betting action for or against the 49ers.
Moneyline Bets
Pick either the favorite or the underdog team to win. Unlike the point spread, you’re simply picking the outright winner.
Moneyline favorites have a minus sign “-” before their number. This number indicates how much you risk to win $100. For example, if the 49ers are -250 favorites, you would risk $250 to win $100.
Moneyline underdogs have a plus sign “+” before their number. This number indicates how much you win if you risk $100. If San Francisco is a +300 underdog, you would risk $100 to win $300.
Betting an obvious favorite to win isn’t always a good idea, even if it’s for the 49ers to win the game. Betting big moneyline favorites means you tie up a large amount of bankroll for a small profit. Sometimes it’s more economical to bet the point spread instead.
Total Bets
Decide whether the sum of both teams’ final scores will be over or under the sportsbook’s total line.
Each side will have its own odds. Occasionally, both sides will have -110 standard odds. Over will be abbreviated as “o” and under will be abbreviated as “u”. Look for each side’s odds to the right of each letter.
With total bets, you have to consider ability of the 49ers and their opponent to put points on the board. Carefully determine whether the game will be a shootout between two high powered offenses, or a grind between two defensive giants. High-scoring games typically will get higher total lines and more expensive over odds compared to lower-scoring games, which will get lower total lines and less expensive under odds.
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San Francisco 49ers Standings
Review the San Francisco 49ers’ current season standings, or have a look at standings from previous years. Current streak and L5 game records can be especially helpful when sizing up a bet. A team’s recent performance is a better indicator of its ability to win games compared to its overall season standing.
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 6 | 11 | 0 | 0.353 | 389 | 436 | 4-5-0 | 2-6-0 | 1-5-0 | 0.167 | 4-8-0 | 0.333 | 4L | 1-4-0 |
FAQs on the San Francisco 49ers
The San Francisco 49ers have a 10.5 game win total line at BetMGM, with the Over +110 and the Under -130. Betting "Over" means you risk $100 to win $110, while a bet on the "Under" means you risk $130 to win $100.
The San Francisco 49ers have +150 odds to not make the 2024-25 playoffs. Betting "No" means a winning $100 bet would pay $150.
As of Wednesday, May 21st, 2025, the San Francisco 49ers have +2000 odds to win Super Bowl 60 at BetMGM. That means a $100 bet would pay $2,000. The implied probability for the San Francisco 49ers to win the Super Bowl is 4.76%.
As of Wednesday, May 21st, 2025, the San Francisco 49ers have +800 odds to win the 2025-26 NFC. You would risk $100 to win $800 on the 49ers to win the NFC at BetMGM. The implied probability for the San Francisco 49ers to win their conference is 11.11%.
As of Wednesday, May 21st, 2025, the San Francisco 49ers have +150 odds to win the 2025-26 NFC West at BetRivers. That means you risk $100 to win $150. The implied probability for the San Francisco 49ers to win their division is 40%.
Betting Odds for Other NFL Teams
- Arizona Cardinals Betting Odds
- Atlanta Falcons Betting Odds
- Baltimore Ravens Betting Odds
- Buffalo Bills Betting Odds
- Carolina Panthers Betting Odds
- Chicago Bears Betting Odds
- Cincinnati Bengals Betting Odds
- Cleveland Browns Betting Odds
- Dallas Cowboys Betting Odds
- Denver Broncos Betting Odds
- Detroit Lions Betting Odds
- Green Bay Packers Betting Odds
- Houston Texans Betting Odds
- Indianapolis Colts Betting Odds
- Jacksonville Jaguars Betting Odds
- Kansas City Chiefs Betting Odds
- Las Vegas Raiders Betting Odds
- Los Angeles Chargers Betting Odds
- Los Angeles Rams Betting Odds
- Miami Dolphins Betting Odds
- Minnesota Vikings Betting Odds
- New England Patriots Betting Odds
- New Orleans Saints Betting Odds
- New York Giants Betting Odds
- New York Jets Betting Odds
- Philadelphia Eagles Betting Odds
- Pittsburgh Steelers Betting Odds
- San Francisco 49ers Betting Odds
- Seattle Seahawks Betting Odds
- Tampa Bay Buccaneers Betting Odds
- Tennessee Titans Betting Odds
- Washington Commanders Betting Odds
NFL Betting Resources
- How to Bet on the NFL – An in-depth look at how to place bets on the NFL, including common straight bets and exotics like parlays, teasers, and props.
- NFL Betting Sites – Our list of the best NFL betting sites features licensed and legal US sportsbooks, just in time for the action on the gridiron.
- NFL Betting Odds – Current NFL odds for upcoming matchups, including the preseason and postseason. Review futures odds, the greatest all-time teams, regular-season standings, and valuable handicapping strategies.
- NFL Prop Bets – Prop bets from upcoming NFL matchups, including a complete NFL prop betting tutorial. Learn how to bet on NFL props.
- NFL Futures Odds – Odds for popular NFL Futures, like the Super Bowl, AFC and NFC conference winners, each division winner, and offensive and defensive player awards. Learn how to bet on NFL futures in minutes.
- NFL Win Total Odds – Review regular season win total lines and odds for each team. Remember to place you bet before each team’s first game of the regular season.
- NFL Game to Overtime Prop Bet – See odds for upcoming games, then review overtime game counts from recent seasons.
- NFL Safety to be Scored Prop Bet – Review odds of a safety happening in upcoming games, then bet “Yes” or “No”.
- NFL First Team to Score Prop Bet – See odds for which team will score first, then learn how to bet on this prop.
- Undefeated NFL Teams – See which teams are still undefeated in the current regular season.
- NFL Biggest Rivalries – Review the NFL’s biggest rivalries by division, catching up on each rivalry’s history and recent matchup results.
- Super Bowl Betting – The latest Super Bowl odds for every NFL team, plus a great guide to how to bet on the Super Bowl. Review how to bet Super Bowl props and recent winning teams.
- Super Bowl Betting Bonuses – See our curated list of betting bonuses just in time for this season’s big game.
- Quarterback Props – Review each quarterback’s regular season performance props. Bet over or under the sportsbook’s line.
- Running Back Props – See performance props for the league’s top running backs. Bet over or under the sportsbook’s line.
- Receiver Props – Have a look at regular season performance lines for receiving yards and receiving touchdowns, then bet over or under the sportsbook’s line.
- How to Read NFL Odds – Great for beginners: learn what the numbers for each bet mean.
- NFL Team Betting Odds – Betting odds and bonuses for each NFL team, including their Super Bowl, Conference, and Division futures, plus historical standings going back to before you were born.