The White Sox will play the Red Sox on Monday, April 21st, 2025. Your timezone's first pitch time is 11:10 am EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Chicago White Sox have a 86.33 power ranking. The power ranking for the Boston Red Sox is 91.67.
- Visiting Chicago White Sox - The Chicago White Sox have a 1-8 record as a visiting team, ranking them 9th Overall for visiting team wins.
- Home Boston Red Sox - The Boston Red Sox have a 6-4 record as a home team. They rank 5th for home team wins in the Overall standings.
- Runs Scored - The Chicago White Sox currently stand 20th (68) Overall, with the Boston Red Sox ranking 7th (104) for runs scored.
- Runs Allowed - The Chicago White Sox are 12th (94) Overall for runs allowed. The Boston Red Sox stand 4th (111) for runs allowed.
- Team Streaks - The Chicago White Sox won their last game. Meanwhile, the Boston Red Sox lost their last game.
- Team Records - The Chicago White Sox have a 5-16 Overall record (7.5 GB American Central Division), with the Boston Red Sox possessing a 12-11 Overall standing (2.5 GB American East Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scurvy dogs! The White Sox be facing the Red Sox at Fenway...
Chicago's record be a disgrace, but they be lookin' to turn the tide...
If ye be brave enough, head to SportsBetting3.com and bet on this game...
The odds be stacked against 'em, but a true pirate never backs down...
Boston be holdin' their own with a winning record at home...
So raise the Jolly Roger and review the odds below, if ye dare!
Best White Sox at Red Sox Odds
| Underdog Chicago White Sox | Favorite Boston Red Sox |
|---|---|
| Over | Under |
|---|---|
| Underdog Chicago White Sox | Favorite Boston Red Sox |
|---|---|
Matchup Odds FAQs
The Boston Red Sox are the -300 moneyline favorite at BetMGM and the Chicago White Sox are the +240 moneyline underdog at BetMGM.
The best over line is 9 -115 runs at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 9 -105 runs at BetMGM, and that means you risk $105 to win $100 betting the under.
The Boston Red Sox are -2.5 +110 run line favorites at BetMGM, while the Chicago White Sox are +2.5 -135 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
White Sox
Red Sox
4/21/25 11:10am EDT | +240-300 |
- Chicago White Sox bettors risk $100 to win $240 at +240 odds. The implied probability for Chicago White Sox is 29.41%.
- Boston Red Sox bettors risk $100 to win $33.33 at -300 odds. The implied probability for Boston Red Sox is 75%.
Chicago White Sox at Boston Red Sox Prop Bets
| BetMGM Bet |
|
|---|---|
White Sox
Red Sox
First Team to Score
4/21/25 11:10am EDT | +110-140Bet |
White Sox
Red Sox
Tie
1st Inning Winner
4/21/25 11:10am EDT | +400+195-118Bet |
White Sox
Red Sox
Tie
First 3 Innings Winner
4/21/25 11:10am EDT | +250-130+333Bet |
White Sox
Red Sox
To Extra Innings
4/21/25 11:10am EDT | Yes +900No -1600Bet |
| BetMGM | |
White Sox
Red Sox
1st Team to Score Will Win
4/21/25 11:10am EDT | Yes -250No +190Bet |
Red Sox
Total Runs
CWS at BOS 4/21/25 11:10am EDT | 5.5 o -1105.5 u -118Bet |
Jonathan Cannon
Strikeouts Thrown
CWS at BOS 4/21/25 11:10am EDT | 4.5 o +1004.5 u -135Bet |
Walker Buehler
Strikeouts Thrown
CWS at BOS 4/21/25 11:10am EDT | 4.5 o -1204.5 u -110Bet |
Chicago White Sox & Boston Red Sox Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Chicago White Sox World Series Odds|
Team | BetMGM |
|---|---|
| White Sox | +50000 Bet |
|
Team | BetMGM |
|---|---|
| Red Sox | +2000 Bet |
Chicago White Sox & Boston Red Sox Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Boston Red Sox | 16 | 14 | 0.533 | +4.5 | 8-6 | 8-8 | 148 | 139 | +9 | W2 | 6-4 |
| Chicago White Sox | 7 | 21 | 0.250 | +12.5 | 4-8 | 3-13 | 95 | 120 | -25 | L1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Chicago White Sox vs Boston Red Sox MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Monday, April 21st, 2025 at 11:10 am EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Chicago White Sox vs Boston Red Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs Boston Red Sox Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other April 21, 2025 MLB Games
- New York Yankees vs Cleveland Guardians - 4/21/25 6:10pm EDT
- Cincinnati Reds vs Miami Marlins - 4/21/25 6:40pm EDT
- San Diego Padres vs Detroit Tigers - 4/21/25 6:40pm EDT
- Philadelphia Phillies vs New York Mets - 4/21/25 7:10pm EDT
- St. Louis Cardinals vs Atlanta Braves - 4/21/25 7:15pm EDT
- Toronto Blue Jays vs Houston Astros - 4/21/25 8:10pm EDT
- Milwaukee Brewers vs San Francisco Giants - 4/21/25 9:45pm EDT