The Astros will play the Angels on Sunday, September 28th, 2025. Your timezone's first pitch time is 3:07 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Astros at Angels Odds
| Underdog Los Angeles Angels | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog Los Angeles Angels | Favorite Houston Astros |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -125 moneyline favorite at BetMGM and the Los Angeles Angels are the +105 moneyline underdog at BetMGM.
The best over line is 9 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 9 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.
The Houston Astros are -1.5 +135 run line favorites at BetMGM, while the Los Angeles Angels are +1.5 -160 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Astros
Angels
9/28/25 3:07pm EDT | -125+105 |
- Los Angeles Angels bettors risk $100 to win $105 at +105 odds. The implied probability for Los Angeles Angels is 48.78%.
- Houston Astros bettors risk $100 to win $80 at -125 odds. The implied probability for Houston Astros is 55.56%.
Houston Astros at Los Angeles Angels Prop Bets
| BetMGM Bet |
|
|---|---|
Astros
Angels
First Team to Score
9/28/25 3:07pm EDT | -180+140Bet |
Astros
Angels
Tie
1st Inning Winner
9/28/25 3:07pm EDT | +250+300-120Bet |
Astros
Angels
Tie
First 3 Innings Winner
9/28/25 3:07pm EDT | +120+154+325Bet |
Astros
Angels
To Extra Innings
9/28/25 3:07pm EDT | Yes +800No -1400Bet |
| BetMGM | |
Astros
Angels
1st Team to Score Will Win
9/28/25 3:07pm EDT | Yes -250No +190Bet |
Astros
Total Runs
HOU at LAA 9/28/25 3:07pm EDT | 4.5 o -1304.5 u -102Bet |
Angels
Total Runs
HOU at LAA 9/28/25 3:07pm EDT | 4.5 o +1054.5 u -140Bet |
Lance McCullers Jr
Strikeouts Thrown
HOU at LAA 9/28/25 3:07pm EDT | 3.5 o -1053.5 u -120Bet |
| BetMGM | |
Samuel Aldegheri
Strikeouts Thrown
HOU at LAA 9/28/25 3:07pm EDT | 3.5 o -1153.5 u -110Bet |
Houston Astros & Los Angeles Angels Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Houston Astros World Series Odds|
Team | BetMGM |
|---|---|
| Astros |
|
Team | BetMGM |
|---|---|
| Angels |
Houston Astros & Los Angeles Angels Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - Houston Astros | 87 | 75 | 0.537 | +10.0 | 46-35 | 41-40 | 686 | 665 | +21 | W2 | 4-6 |
| e - Los Angeles Angels | 72 | 90 | 0.444 | +25.0 | 39-42 | 33-48 | 673 | 837 | -164 | L2 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Houston Astros vs Los Angeles Angels MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 3:07 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Houston Astros vs Los Angeles Angels Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Los Angeles Angels Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 28, 2025 MLB Games
- Colorado Rockies vs San Francisco Giants
- Minnesota Twins vs Philadelphia Phillies
- Baltimore Orioles vs New York Yankees
- Chicago White Sox vs Washington Nationals
- Detroit Tigers vs Boston Red Sox
- Kansas City Royals vs Oakland Athletics
- Tampa Bay Rays vs Toronto Blue Jays
- Texas Rangers vs Cleveland Guardians
- New York Mets vs Miami Marlins
- Arizona Diamondbacks vs San Diego Padres
- Cincinnati Reds vs Milwaukee Brewers
- Los Angeles Dodgers vs Seattle Mariners
- Pittsburgh Pirates vs Atlanta Braves
- St. Louis Cardinals vs Chicago Cubs