The Tigers will play the Cardinals on Saturday, November 6th, 2021. The matchup takes place at Cardinal Stadium. Watch this exciting Week 10 matchup at 7:30 pm EDT. Check local listings for coverage on ACCN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Schedules & Results
- Other Games Today
Best Tigers at Cardinals Odds
Underdog | Favorite |
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Over | Under |
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Underdog | Favorite |
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College Football Odds Example
Game |
Bet |
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2:16pm EDT | TBD OH,US |
No OH,US Point Spread lines available for this game.
Clemson at Louisville Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
BetMGM Bet |
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Clemson
Louisville
11/06/21 7:30pm EDT | Pending BetMGM |
Recent Meetings Since 2017
Week | Game | Result | Margin |
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2022 Week 11 | Louisville vs Clemson Saturday, November 12th, 2022 | CLEM 31, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 15 |
2021 Week 10 | Clemson vs Louisville Saturday, November 6th, 2021 | CLEM 30, LOU 24 Cardinal Stadium | Clemson by 6 |
2019 Week 8 | Clemson vs Louisville Saturday, October 19th, 2019 | CLEM 45, LOU 10 Cardinal Stadium | Clemson by 35 |
2018 Week 10 | Louisville vs Clemson Saturday, November 3rd, 2018 | CLEM 77, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 61 |
2017 Week 3 | Clemson vs Louisville Saturday, September 16th, 2017 | CLEM 47, LOU 21 Cardinal Stadium | Clemson by 26 |
Team Standings
Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
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#14 Clemson | 6-2 | 0.750 | 10 | 3 | 342 | 193 | 6-0 | 3-2 | W6 |
Louisville | 4-4 | 0.500 | 6 | 7 | 411 | 355 | 4-3 | 2-2 | L2 |
Clemson & Louisville Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Clemson Championship Odds
Team | BetMGM | BetRivers |
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Clemson | +3000 Bet | +2000 Bet |
Team | BetMGM | BetRivers |
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Louisville | +10000 Bet | +10000 Bet |
Team Schedules & Results
Week | Matchup | Date & Result |
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Week 1 | Georgia vs Clemson | UGA 10, CLEM 3 Saturday, September 4th, 2021 |
Week 2 | South Carolina State vs Clemson | CLEM 49, SCST 3 Saturday, September 11th, 2021 |
Week 3 | Georgia Tech vs Clemson | CLEM 14, GT 8 Saturday, September 18th, 2021 |
Week 4 | Clemson vs NC State | NCST 27, CLEM 21 (2OT) Saturday, September 25th, 2021 |
Week 5 | Boston College vs Clemson | CLEM 19, BC 13 Saturday, October 2nd, 2021 |
Week 7 | Clemson vs Syracuse | CLEM 17, SYR 14 Friday, October 15th, 2021 |
Week 8 | Clemson vs Pittsburgh | PITT 27, CLEM 17 Saturday, October 23rd, 2021 |
Week 9 | Florida State vs Clemson | CLEM 30, FSU 20 Saturday, October 30th, 2021 |
Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
Week 11 | UConn vs Clemson | CLEM 44, CONN 7 Saturday, November 13th, 2021 |
Week 12 | Wake Forest vs Clemson | CLEM 48, WAKE 27 Saturday, November 20th, 2021 |
Week 13 | Clemson vs South Carolina | CLEM 30, SC 0 Saturday, November 27th, 2021 |
Bowls | Clemson vs Iowa State Cheez-It Bowl | CLEM 20, ISU 13 Wednesday, December 29th, 2021 |
Week | Matchup | Date & Result |
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Week 1 | Louisville vs Ole Miss | MISS 43, LOU 24 Monday, September 6th, 2021 |
Week 2 | Eastern Kentucky vs Louisville | LOU 30, EKU 3 Saturday, September 11th, 2021 |
Week 3 | UCF vs Louisville | LOU 42, UCF 35 Friday, September 17th, 2021 |
Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
Week 5 | Louisville vs Wake Forest | WAKE 37, LOU 34 Saturday, October 2nd, 2021 |
Week 6 | Virginia vs Louisville | UVA 34, LOU 33 Saturday, October 9th, 2021 |
Week 8 | Boston College vs Louisville | LOU 28, BC 14 Saturday, October 23rd, 2021 |
Week 9 | Louisville vs NC State | NCST 28, LOU 13 Saturday, October 30th, 2021 |
Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
Week 11 | Syracuse vs Louisville | LOU 41, SYR 3 Saturday, November 13th, 2021 |
Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
Week 13 | Kentucky vs Louisville | UK 52, LOU 21 Saturday, November 27th, 2021 |
Bowls | Air Force vs Louisville Servpro First Responder Bowl | AFA 31, LOU 28 Tuesday, December 28th, 2021 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Clemson vs Louisville College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 6th, 2021 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Clemson vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Clemson vs Louisville Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.