The Panthers will play the 49ers on Monday, November 24th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 12 matchup at 8:15 pm EST. Check local listings for coverage on ESPN.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 12, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the Carolina Panthers and San Francisco 49ers. They'll play on Monday, November 24th, 2025 at Levi's Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 12 of the 2025-26 NFL regular season, the Carolina Panthers have a 90.00 power ranking based on our formula. Their opponent, the San Francisco 49ers, currently possess a 93.33 power ranking.
- Away Carolina Panthers - With the season coming to a close, the Carolina Panthers have a 3-3-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers come to this Week 12 game with a 2-2-0 record as a home team. They rank 5th in the league for home team wins as the 2025-26 regular season wraps up.
- Points Scored - The Carolina Panthers currently rank 22nd (207) headed into Week 12, with the San Francisco 49ers ranked 6th (261) for points scored to date.
- Points Against - As the regular season winds down, the Carolina Panthers rank 14th (249) for points score against them. Note that the San Francisco 49ers now rank 11th (252) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 12, the Carolina Panthers have a 6-5-0 record, with the San Francisco 49ers at 7-4-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Carolina Panthers be facin' off against the San Francisco 49ers.
This be a crucial Week 12 matchup as the NFL regular season nears its end.
The Panthers be standin' at 6-5-0, while the 49ers be standin' at 7-4-0.
Make sure to place a bet at BetRivers or BetMGM, and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks.
Best Panthers at 49ers Odds
| Underdog Carolina Panthers | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Carolina Panthers | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -7 -120 point spread favorites at BetMGM, while the Carolina Panthers are +7 +100 point spread underdogs at BetMGM.
The best over line is 49 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 49 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -350 moneyline favorite at BetMGM and the Carolina Panthers are the +280 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Panthers
49ers
11/24/25 8:15pm EST | +7 +100-7 -120 |
Underdog Carolina Panthers - Carolina Panthers bettors risk $100 to win $100 at +100 odds.
A +7 Carolina Panthers underdog bet wins if they lose by 6 or fewer, tie, or win outright. The bet pushes if they lose by 7. Your bet loses if they lose by 8 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $83.33 at -120 odds.
A -7 San Francisco 49ers favorite bet wins if they win by 8 or more. The bet pushes if they win by 7. Your bet loses if they win by 6 or fewer, tie, or lose outright.
Carolina Panthers at San Francisco 49ers Prop Bets
| BetMGM Bet |
|
|---|---|
Panthers
49ers
First Team To Score
11/24/25 8:15pm EST | +125-160Bet |
Panthers
49ers
No Touchdown
To Score 1st Touchdown
11/24/25 8:15pm EST | +145-200+10000Bet |
Panthers
49ers
Game to Overtime
11/24/25 8:15pm EST | Yes +850No -3000Bet |
Panthers
49ers
Safety to be Scored
11/24/25 8:15pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
CAR at SF 11/24/25 8:15pm EST | 0.5 o +1000.5 u -135Bet |
Bryce Young
Interceptions Thrown
CAR at SF 11/24/25 8:15pm EST | 0.5 o -1250.5 u -105Bet |
Brock Purdy
Longest Passing Completion
CAR at SF 11/24/25 8:15pm EST | 36.5 o -11536.5 u -115Bet |
Bryce Young
Longest Passing Completion
CAR at SF 11/24/25 8:15pm EST | 32.5 o +10032.5 u -130Bet |
| BetMGM | |
Eddy Pineiro
Total Kicking Points
CAR at SF 11/24/25 8:15pm EST | 7.5 o -1257.5 u -105Bet |
Matt Gay
Total Kicking Points
CAR at SF 11/24/25 8:15pm EST | 7.5 o -1257.5 u -105Bet |
Ryan Fitzgerald
Total Kicking Points
CAR at SF 11/24/25 8:15pm EST | 6.5 o -1056.5 u -125Bet |
Brock Purdy
Total Pass Completions
CAR at SF 11/24/25 8:15pm EST | 21.5 o -12021.5 u -110Bet |
| BetMGM | |
Bryce Young
Total Pass Completions
CAR at SF 11/24/25 8:15pm EST | 20.5 o +10020.5 u -130Bet |
Brock Purdy
Total Passing Yards
CAR at SF 11/24/25 8:15pm EST | 259.5 o -115259.5 u -115Bet |
Bryce Young
Total Passing Yards
CAR at SF 11/24/25 8:15pm EST | 214.5 o -115214.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
CAR at SF 11/24/25 8:15pm EST | 1.5 o -2351.5 u +175Bet |
| BetMGM | |
Bryce Young
Total Touchdown Passes
CAR at SF 11/24/25 8:15pm EST | 1.5 o +1101.5 u -150Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 12 | Panthers vs 49ers Monday, November 24th, 2025 | SF 20, CAR 9 Levi's Stadium | 49ers by 11 |
| 2022 Week 5 | 49ers vs Panthers Sunday, October 9th, 2022 | SF 37, CAR 15 Bank of America Stadium | 49ers by 22 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 10 | 4 | 0 | 0.714 | 344 | 293 | 4-2-0 | 6-2-0 | 4-1-0 | 0.800 | 8-2-0 | 0.800 | 4W | 4-1-0 |
| Carolina Panthers | 7 | 7 | 0 | 0.500 | 264 | 317 | 4-2-0 | 3-5-0 | 2-2-0 | 0.500 | 5-4-0 | 0.556 | 1L | 2-3-0 |
Carolina Panthers & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Carolina Panthers Futures Odds|
Team | BetMGM |
|---|---|
| Panthers | +30000 Bet |
|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
Carolina Panthers & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Carolina Panthers vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Monday, November 24th, 2025 at 8:15 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Carolina Panthers vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.