The Panthers will play the 49ers on Monday, November 24th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 12 matchup at 8:15 pm EST. Check local listings for coverage on ESPN.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 12, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the Carolina Panthers and San Francisco 49ers. They'll play on Monday, November 24th, 2025 at Levi's Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 12 of the 2025-26 NFL regular season, the Carolina Panthers have a 90.00 power ranking based on our formula. Their opponent, the San Francisco 49ers, currently possess a 93.33 power ranking.
- Away Carolina Panthers - With the season coming to a close, the Carolina Panthers have a 3-3-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers come to this Week 12 game with a 2-2-0 record as a home team. They rank 5th in the league for home team wins as the 2025-26 regular season wraps up.
- Points Scored - The Carolina Panthers currently rank 22nd (207) headed into Week 12, with the San Francisco 49ers ranked 6th (261) for points scored to date.
- Points Against - As the regular season winds down, the Carolina Panthers rank 14th (249) for points score against them. Note that the San Francisco 49ers now rank 11th (252) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 12, the Carolina Panthers have a 6-5-0 record, with the San Francisco 49ers at 7-4-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Carolina Panthers be facin' off against the San Francisco 49ers.
This be a crucial Week 12 matchup as the NFL regular season nears its end.
The Panthers be standin' at 6-5-0, while the 49ers be standin' at 7-4-0.
Make sure to place a bet at BetRivers or BetMGM, and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks.
Best Panthers at 49ers Odds
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NFL Odds Example
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Carolina Panthers at San Francisco 49ers Prop Bets
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Panthers
49ers
11/24/25 8:15pm EST | Pending |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 12 | Panthers vs 49ers Monday, November 24th, 2025 | SF 20, CAR 9 Levi's Stadium | 49ers by 11 |
| 2022 Week 5 | 49ers vs Panthers Sunday, October 9th, 2022 | SF 37, CAR 15 Bank of America Stadium | 49ers by 22 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| xy - San Francisco 49ers | 12 | 5 | 0 | 0.706 | 437 | 371 | 5-3-0 | 7-2-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1L | 4-1-0 |
| xz - Carolina Panthers | 8 | 9 | 0 | 0.471 | 311 | 380 | 5-3-0 | 3-6-0 | 3-3-0 | 0.500 | 6-6-0 | 0.500 | 2L | 2-3-0 |
Carolina Panthers & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Carolina Panthers Futures OddsNo Super Bowl TM Carolina Panthers YR: futures available
San Francisco 49ers Futures OddsNo Super Bowl TM San Francisco 49ers YR: futures available
Carolina Panthers & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Carolina Panthers vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Monday, November 24th, 2025 at 8:15 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Carolina Panthers vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.