The Eagles will play the Bills on Sunday, December 28th, 2025. The matchup takes place at Highmark Stadium. Watch this exciting Week 17 matchup at 4:25 pm EST. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

STATE	Bonus

Matchup Stats
Captain Shady Lines
Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
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Key Matchup Stats

The 2025-26 NFL regular season is winding down. One of the upcoming Week 17 matchups includes a battle between the Philadelphia Eagles and Buffalo Bills . Set for Sunday, December 28th, 2025 at Highmark Stadium, the result of this game may affect this season's playoff picture. Take note of each team's performance stats below. Any late-season momentum will likely carryover into the playoffs.

SportsBetting3.com Power Rankings - Looking at Week 17 of the 2025-26 NFL regular season, the Philadelphia Eagles have a 94.00 power ranking based on our formula. The Buffalo Bills currently possess a 97.00 power ranking as the regular season wraps up.
Away Philadelphia Eagles - The Philadelphia Eagles have a 5-3-0 record as an away team for the 2025-26 regular season, ranking them 3rd in the league for away team wins.
Home Buffalo Bills - As for the Buffalo Bills, they come to this Week 17 game with a 6-1-0 record as a home team. They rank 2nd in the league for home team wins.
Points Scored - The Philadelphia Eagles currently rank 13th (349) as we approach Week 17, with the Buffalo Bills ranked 4th (434) for points scored to date.
Points Against - With the regular season concluding, the Philadelphia Eagles rank 29th (289) for points score against them. Note that the Buffalo Bills now rank 17th (344) for points scored against.
Team Records - The final games of the season will determine who heads to the playoffs. As Week 17 action looms, the Philadelphia Eagles have a 10-5-0 record, with the Buffalo Bills at 11-4-0 for the 2025-26 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scurvy dogs! The Eagles be facing the Bills in a crucial battle!

The regular season nears its end, with playoff hopes on the line.

BetRivers and BetMGM are the best legal NFL sportsbooks - make yer bets now!

The Eagles stand at 10-5-0, while the Bills be at 11-4-0. It be a clash of titans!

We've gathered this matchup's prop bets below - place yer wagers wisely!

The game be at Highmark Stadium - the stage be set for a fierce showdown!

Review the best point spread, total, and moneyline odds for this matchup in the following tables. May the best team prevail on this fateful day!

Best Eagles at Bills Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

Philadelphia Eagles at Buffalo Bills Prop Bets

NFL Prop Bets
+ Displays more odds
	Bet
Eagles Bills 12/28/25 4:25pm EST	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 17	Eagles vs Bills Sunday, December 28th, 2025	PHI 13, BUF 12 Highmark Stadium	Eagles by 1
2023 Week 12	Bills vs Eagles Sunday, November 26th, 2023	PHI 37, BUF 34 (OT) Lincoln Financial Field	Eagles by 3

Team Standings

2025-2026 NFL Regular Season Standings - Philadelphia Eagles, Buffalo Bills
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - Buffalo Bills	12	5	0	0.706	481	365	7-2-0	5-3-0	4-2-0	0.667	9-3-0	0.750	1W	4-1-0
xz - Philadelphia Eagles	11	6	0	0.647	379	325	5-3-0	6-3-0	3-3-0	0.500	8-4-0	0.667	1L	3-2-0

Philadelphia Eagles & Buffalo Bills Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Philadelphia Eagles Futures Odds

No Super Bowl TM Philadelphia Eagles YR: futures available

Buffalo Bills Futures Odds

No Super Bowl TM Buffalo Bills YR: futures available

Philadelphia Eagles & Buffalo Bills Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Philadelphia Eagles vs Buffalo Bills NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 28th, 2025 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Philadelphia Eagles vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Philadelphia Eagles vs Buffalo Bills Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Philadelphia Eagles vs Buffalo Bills Odds

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