The Eagles will play the Bills on Sunday, December 28th, 2025. The matchup takes place at Highmark Stadium. Watch this exciting Week 17 matchup at 4:25 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season is winding down. One of the upcoming Week 17 matchups includes a battle between the Philadelphia Eagles and Buffalo Bills . Set for Sunday, December 28th, 2025 at Highmark Stadium, the result of this game may affect this season's playoff picture. Take note of each team's performance stats below. Any late-season momentum will likely carryover into the playoffs.
- SportsBetting3.com Power Rankings - Looking at Week 17 of the 2025-26 NFL regular season, the Philadelphia Eagles have a 94.00 power ranking based on our formula. The Buffalo Bills currently possess a 97.00 power ranking as the regular season wraps up.
- Away Philadelphia Eagles - The Philadelphia Eagles have a 5-3-0 record as an away team for the 2025-26 regular season, ranking them 3rd in the league for away team wins.
- Home Buffalo Bills - As for the Buffalo Bills, they come to this Week 17 game with a 6-1-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The Philadelphia Eagles currently rank 13th (349) as we approach Week 17, with the Buffalo Bills ranked 4th (434) for points scored to date.
- Points Against - With the regular season concluding, the Philadelphia Eagles rank 29th (289) for points score against them. Note that the Buffalo Bills now rank 17th (344) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. As Week 17 action looms, the Philadelphia Eagles have a 10-5-0 record, with the Buffalo Bills at 11-4-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scurvy dogs! The Eagles be facing the Bills in a crucial battle!
The regular season nears its end, with playoff hopes on the line.
BetRivers and BetMGM are the best legal NFL sportsbooks - make yer bets now!
The Eagles stand at 10-5-0, while the Bills be at 11-4-0. It be a clash of titans!
We've gathered this matchup's prop bets below - place yer wagers wisely!
The game be at Highmark Stadium - the stage be set for a fierce showdown!
Review the best point spread, total, and moneyline odds for this matchup in the following tables. May the best team prevail on this fateful day!
Best Eagles at Bills Odds
| Underdog Philadelphia Eagles | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Philadelphia Eagles | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -3 -115 point spread favorites at BetMGM, while the Philadelphia Eagles are +3 -105 point spread underdogs at BetMGM.
The best over line is 45 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 45 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -160 moneyline favorite at BetMGM and the Philadelphia Eagles are the +135 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Eagles
Bills
12/28/25 4:25pm EST | +3 -105-3 -115 |
Underdog Philadelphia Eagles - Philadelphia Eagles bettors risk $100 to win $95.24 at -105 odds.
A +3 Philadelphia Eagles underdog bet wins if they lose by 2 or fewer, tie, or win outright. The bet pushes if they lose by 3. Your bet loses if they lose by 4 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $86.96 at -115 odds.
A -3 Buffalo Bills favorite bet wins if they win by 4 or more. The bet pushes if they win by 3. Your bet loses if they win by 2 or fewer, tie, or lose outright.
Philadelphia Eagles at Buffalo Bills Prop Bets
| BetMGM Bet |
|
|---|---|
Eagles
Bills
First Team To Score
12/28/25 4:25pm EST | -102-125Bet |
Eagles
Bills
No Touchdown
To Score 1st Touchdown
12/28/25 4:25pm EST | +105-140+10000Bet |
Eagles
Bills
Game to Overtime
12/28/25 4:25pm EST | Yes +700No -2000Bet |
Eagles
Bills
Safety to be Scored
12/28/25 4:25pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Jalen Hurts
Interceptions Thrown
PHI at BUF 12/28/25 4:25pm EST | 0.5 o +1200.5 u -160Bet |
Josh Allen
Interceptions Thrown
PHI at BUF 12/28/25 4:25pm EST | 0.5 o +1150.5 u -150Bet |
Jalen Hurts
Longest Passing Completion
PHI at BUF 12/28/25 4:25pm EST | 32.5 o -11832.5 u -110Bet |
Josh Allen
Longest Passing Completion
PHI at BUF 12/28/25 4:25pm EST | 33.5 o -11533.5 u -115Bet |
| BetMGM | |
Jake Elliott
Total Kicking Points
PHI at BUF 12/28/25 4:25pm EST | 6.5 o -1056.5 u -125Bet |
Michael Badgley
Total Kicking Points
PHI at BUF 12/28/25 4:25pm EST | 5.5 o -1455.5 u +110Bet |
Jalen Hurts
Total Pass Completions
PHI at BUF 12/28/25 4:25pm EST | 17.5 o +10517.5 u -140Bet |
Josh Allen
Total Pass Completions
PHI at BUF 12/28/25 4:25pm EST | 18.5 o -11018.5 u -120Bet |
| BetMGM | |
Jalen Hurts
Total Passing Yards
PHI at BUF 12/28/25 4:25pm EST | 188.5 o +105188.5 u -145Bet |
Josh Allen
Total Passing Yards
PHI at BUF 12/28/25 4:25pm EST | 199.5 o -115199.5 u -115Bet |
Jalen Hurts
Total Touchdown Passes
PHI at BUF 12/28/25 4:25pm EST | 1.5 o +1401.5 u -190Bet |
Josh Allen
Total Touchdown Passes
PHI at BUF 12/28/25 4:25pm EST | 1.5 o +1201.5 u -160Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 17 | Eagles vs Bills Sunday, December 28th, 2025 | PHI 13, BUF 12 Highmark Stadium | Eagles by 1 |
| 2023 Week 12 | Bills vs Eagles Sunday, November 26th, 2023 | PHI 37, BUF 34 (OT) Lincoln Financial Field | Eagles by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - Buffalo Bills | 12 | 5 | 0 | 0.706 | 481 | 365 | 7-2-0 | 5-3-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1W | 4-1-0 |
| xz - Philadelphia Eagles | 11 | 6 | 0 | 0.647 | 379 | 325 | 5-3-0 | 6-3-0 | 3-3-0 | 0.500 | 8-4-0 | 0.667 | 1L | 3-2-0 |
Philadelphia Eagles & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Philadelphia Eagles Futures OddsNo Super Bowl TM Philadelphia Eagles YR: futures available
Buffalo Bills Futures OddsNo Super Bowl TM Buffalo Bills YR: futures available
Philadelphia Eagles & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Philadelphia Eagles vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 28th, 2025 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Philadelphia Eagles vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Philadelphia Eagles vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 28, 2025 NFL Games
- Houston Texans vs Los Angeles Chargers
- Seattle Seahawks vs Carolina Panthers
- New Orleans Saints vs Tennessee Titans
- New England Patriots vs New York Jets
- Tampa Bay Buccaneers vs Miami Dolphins
- Jacksonville Jaguars vs Indianapolis Colts
- Arizona Cardinals vs Cincinnati Bengals
- Pittsburgh Steelers vs Cleveland Browns
- New York Giants vs Las Vegas Raiders
- Chicago Bears vs San Francisco 49ers