The 49ers will play the Rams on Thursday, September 10th, 2026. The matchup takes place at Melbourne Cricket Ground. Watch this exciting Week 1 matchup at 8:35 pm EDT. Check local listings for coverage on Netflix.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's early in the 2026-27 NFL regular season for the San Francisco 49ers and Los Angeles Rams. Let's review some stats from the 2025 regular season to get an idea of how these teams will fare.
- SportsBetting3.com Power Rankings - The San Francisco 49ers had a 94.00 power ranking in the 2025 regular season. The power ranking for the Los Angeles Rams in the 2025 regular season was 96.67.
- Away San Francisco 49ers - At the end of the 2025 regular season, the San Francisco 49ers had a 7-2-0 record as an away team, ranking them 2nd in the regular season for away team wins.
- Home Los Angeles Rams - The Los Angeles Rams finished the 2025 regular season with a 7-1-0 record as a home team. They ranked 2nd for home team wins in the regular season standings.
- Points Scored - The San Francisco 49ers wound up 9th (437) in the regular season, with the Los Angeles Rams ranked 1st (518) for points scored in the 2025 regular season.
- Points Against - The San Francisco 49ers finished 20th (371) in the regular season for points against. The Los Angeles Rams wound up 23rd (346) in the 2025 regular season for points against.
- Team Records - The San Francisco 49ers had a 12-5-0 regular season record, with the Los Angeles Rams notching a 12-5-0 regular season standing last year.
Best 49ers at Rams Odds
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NFL Odds Example
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San Francisco 49ers at Los Angeles Rams Prop Bets
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49ers
Rams
9/10/26 8:35pm EDT | Pending |
Recent Meetings Since 2022
| Week | Game | Result | Margin |
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| 2026 Week 1 | 49ers vs Rams Thursday, September 10th, 2026 | SF 27, LAR 7 Melbourne Cricket Ground | 49ers by 20 |
| 2025 Week 10 | Rams vs 49ers Sunday, November 9th, 2025 | LAR 42, SF 26 Levi's Stadium | Rams by 16 |
| 2025 Week 5 | 49ers vs Rams Thursday, October 2nd, 2025 | SF 26, LAR 23 (OT) SoFi Stadium | 49ers by 3 |
| 2024 Week 15 | Rams vs 49ers Thursday, December 12th, 2024 | LAR 12, SF 6 Levi's Stadium | Rams by 6 |
| 2024 Week 3 | 49ers vs Rams Sunday, September 22nd, 2024 | LAR 27, SF 24 SoFi Stadium | Rams by 3 |
| 2023 Week 18 | Rams vs 49ers Sunday, January 7th, 2024 | LAR 21, SF 20 Levi's Stadium | Rams by 1 |
| 2023 Week 2 | 49ers vs Rams Sunday, September 17th, 2023 | SF 30, LAR 23 SoFi Stadium | 49ers by 7 |
| 2022 Week 8 | 49ers vs Rams Sunday, October 30th, 2022 | SF 31, LAR 14 SoFi Stadium | 49ers by 17 |
| 2022 Week 4 | Rams vs 49ers Monday, October 3rd, 2022 | SF 24, LAR 9 Levi's Stadium | 49ers by 15 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| San Francisco 49ers | 5 | 0 | 0 | 1.000 | 154 | 93 | 3-0-0 | 2-0-0 | 3-0-0 | 1.000 | 3-0-0 | 1.000 | 5W | 5-0-0 |
| Los Angeles Rams | 2 | 2 | 0 | 0.500 | 85 | 83 | 1-1-0 | 1-1-0 | 0-1-0 | 0.000 | 2-1-0 | 0.667 | 1W | 2-2-0 |
San Francisco 49ers & Los Angeles Rams Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures OddsNo Super Bowl TM San Francisco 49ers YR: futures available
Los Angeles Rams Futures OddsNo Super Bowl TM Los Angeles Rams YR: futures available
San Francisco 49ers & Los Angeles Rams Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Los Angeles Rams NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 10th, 2026 at 8:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Los Angeles Rams Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Los Angeles Rams Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.