The Chargers will play the 49ers on Saturday, August 23rd, 2025. The matchup takes place at Levi's Stadium. Watch this exciting preseason matchup at 8:30 pm EDT. Check local listings for coverage on ESPN Unlmtd.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

STATE	Bonus

Matchup Stats
Captain Shady Lines
Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
Team Pages
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Key Matchup Stats

The 2025-26 NFL preseason is underway for the Los Angeles Chargers and San Francisco 49ers. Let's review each team's stats in anticipation of their upcoming matchup. Preseason results do not affect a team's chances of making the playoffs. Remember, the regular season begins soon!

SportsBetting3.com Power Rankings - The Los Angeles Chargers currently have a 98.33 preseason power ranking (91.67 for the 2024 preseason). Contrast this to the San Francisco 49ers who'll play this matchup with a 91.67 preseason power ranking (93.00 in 2024).
Away Los Angeles Chargers - The Los Angeles Chargers currently have a 1-1-0 record as an away team (1-0-0 in 2024). They now rank 2nd for away team wins in the preseason standings.
Home San Francisco 49ers - The San Francisco 49ers currently have a 0-1-0 record as a home team (1-0-0 in 2024). They now rank 3rd for home team wins in the preseason standings.
Points Scored - The Los Angeles Chargers rank 1st (83) in the preseason, with the San Francisco 49ers ranked 20th (31) for points scored in the 2025 preseason.
Points Against - The Los Angeles Chargers are 11th (43) in the preseason for points against. The San Francisco 49ers stand 6th (49) in the 2025 preseason for points against.
Team Records - The Los Angeles Chargers have a 2-1-0 preseason record, with the San Francisco 49ers at 1-1-0. Last year, the Los Angeles Chargers had a 1-2-0 preseason record, with the San Francisco 49ers finishing with a 1-1-1 standing.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The Chargers be sailin' to Levi's Stadium for battle. Preseason scuffle... Chargers stand tall at 2-1-0 while them 49ers be at 1-1-0. SportsBetting3.com.

Ye best be ready for a showdown on August 23rd. Bet on this game... review the odds below. The Chargers be lookin' to plunder victory from the 49ers. Aye!

Best Chargers at 49ers Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

Los Angeles Chargers at San Francisco 49ers Prop Bets

NFL Prop Bets
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	Bet
Chargers 49ers 8/23/25 8:30pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2026 Preseason Week 2	49ers vs Chargers Thursday, August 20th, 2026	SF 41, LAC 17 SoFi Stadium	49ers by 24
2025 Preseason Week 3	Chargers vs 49ers Saturday, August 23rd, 2025	SF 30, LAC 23 Levi's Stadium	49ers by 7
2023 Preseason Week 3	Chargers vs 49ers Friday, August 25th, 2023	LAC 23, SF 12 Levi's Stadium	Chargers by 11
2022 Week 10	Chargers vs 49ers Sunday, November 13th, 2022	SF 22, LAC 16 Levi's Stadium	49ers by 6
2021 Preseason Week 2	49ers vs Chargers Sunday, August 22nd, 2021	SF 15, LAC 10 SoFi Stadium	49ers by 5

Team Standings

2025-2026 NFL Regular Season Standings - Los Angeles Chargers, San Francisco 49ers
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	12	5	0	0.706	437	371	5-3-0	7-2-0	4-2-0	0.667	9-3-0	0.750	1L	4-1-0
xy - Los Angeles Chargers	11	6	0	0.647	368	340	6-3-0	5-3-0	5-1-0	0.833	8-4-0	0.667	2L	3-2-0

Los Angeles Chargers & San Francisco 49ers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Los Angeles Chargers Futures Odds

No Super Bowl TM Los Angeles Chargers YR: futures available

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Los Angeles Chargers & San Francisco 49ers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Los Angeles Chargers vs San Francisco 49ers NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, August 23rd, 2025 at 8:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Los Angeles Chargers vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Los Angeles Chargers vs San Francisco 49ers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Los Angeles Chargers vs San Francisco 49ers Odds

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