Duke vs Louisville Basketball Odds

The Blue Devils will play the Cardinals on Tuesday, January 6th, 2026. Your timezone's tip off time is 7:00 pm EST. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.


Bonus
BetMGM Sportsbook#1 BetMGM
REVIEW
New Customers - Up to $1500 Paid Back in Bonus Bets
Bonus Bets Expire in 7 Days
One new customer offer/Add'l Terms

Bet Now
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Table of Contents

Key Matchup Stats

Looking into the second half of the 2025-26 college basketball season, Duke and Louisville are set to hit the hardwood on Tuesday, January 6th, 2026. Luckily, we have some clear performance trends emerging now that each team has more than a dozen games under their belts. Use the following data to help analyze this matchup and to place an intelligent wager on its ultimate outcome.

  • SportsBetting3.com Power Rankings - With the 2025-26 season in full stride, Duke currently has a 99.00 conference power ranking, while the SportsBetting3.com conference power ranking for Louisville is 96.33.
  • Away Duke - Duke starts this game with a 3-0 record as an away team, ranking them 1st in the ACC Conference for away team wins.
  • Home Louisville - Louisville meets Duke boasting a 8-0 record as a home team. They currently rank 4th in the ACC Conference for home team wins.
  • Conference Win Percentage - Duke currently ranks 1st (1.000) in the ACC Conference, with Louisville now standing 2nd (0.500) for their conference win percentage in the 2025 ACC Conference for the 2025-26 college basketball season.
  • Overall Win Percentage - Duke has a 0.929 overall win percentage, with Louisville matching up with a 0.786 overall win percentage.
  • Team Records - Duke currently possesses 13-1 regular season overall record. Meanwhile, Louisville has tallied a 11-3 standing as the 2025-26 college basketball season continues to unfold.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Moneyline Mage
Moneyline Mage

Beware! Duke 13-1, Louisville 11-3 clash in battle of titans on Tuesday!

Conference records crucial for tournament seeds. Duke 2-0, Louisville 1-1 in ACC.

Duke on 2-game win streak, Louisville coming off loss. Watch out wizards! Review the tables below to find the best point spread, total, and moneylines for this game. You can bet on college basketball legally at BetRivers and BetMGM. We've also listed each team's futures odds and current standings below.

Best Blue Devils at Cardinals Odds


Best Point Spread Betting Odds
Underdog

Louisville
Favorite

Duke
Duke has a -1.5 +100 point spread at BetMGM OH. They are the point spread favorite in this matchup. Louisville has a +1.5 -120 point spread at BetMGM OH. Louisville is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 161.5 points. Risk $110 to win $100. BetMGM has the best under line of 161.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Louisville
Favorite

Duke
Duke is the -110 moneyline favorite. Risk $110 to win $100 on Duke at BetMGM. Louisville is the -110 underdog at BetMGM. Risk $110 to win $100 on Louisville. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Duke vs Louisville College Basketball game on Tuesday, January 6th, 2026?

Duke is a -1.5 +100 point spread favorite at BetMGM, while Louisville is a +1.5 -120 point spread underdog at BetMGM.

What is the over-under total line for the Duke vs Louisville College Basketball game on Tuesday, January 6th, 2026?

The best over line is 161.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 161.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Duke vs Louisville College Basketball game on Tuesday, January 6th, 2026?

Duke is a -110 moneyline favorite at BetMGM and Louisville is a -110 moneyline underdog at BetMGM.

College Basketball Odds Example

College Basketball Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Duke
Louisville
1/06/26 7:00pm EST
-1.5 +100+1.5 -120
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Underdog Louisville - Louisville bettors risk $100 to win $83.33 at -120 odds.

A +1.5 Louisville underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.

Favorite Duke - Duke bettors risk $100 to win $100 at +100 odds.

A -1.5 Duke favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.

Duke at Louisville Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Basketball Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Duke
Louisville
First to 5 Points
1/06/26 7:00pm EST
-115-118Bet
Duke
Louisville
First to 10 Points
1/06/26 7:00pm EST
-115-120Bet
Duke
Louisville
First to 15 Points
1/06/26 7:00pm EST
-115-120Bet
Duke
Louisville
Game to Overtime
1/06/26 7:00pm EST
Yes +800No -3000Bet

Team Standings

2025-2026 College Basketball Regular Season Standings - Duke, Louisville
Team W-L Win% Home Away Conf CGB Conf% Strk
#4 Duke20-10.95210-07-09-0-1.000W9
#20 Louisville15-60.71411-22-45-4+40.556W1

Duke & Louisville Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

Duke Championship Odds
2025-26 Duke NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending
Louisville Championship Odds
2025-26 Louisville NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending

Duke & Louisville Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Duke vs Louisville College Basketball Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Tuesday, January 6th, 2026 at 7:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Basketball page, look for the Duke vs Louisville Game.

    Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Duke vs Louisville Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other January 6, 2026 NCAABB Games

Odds Preview 26854