The Cardinals will play the Spartans on Saturday, March 21st, 2026. Your timezone's tip off time is 2:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Review our College Basketball Betting guide to learn how to bet this game.
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Table of Contents
- Matchup Stats
- Moneyline Mage
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 college basketball postseason has arrived. With tournament action on the docket, Louisville and Michigan State are set to tip-off on Saturday, March 21st, 2026. Here's your chance to partake in March Madness! The end of the regular season has left us with solid trends for each team. Use the following performance insights and stats to handicap what promises to be an exciting matchup.
- SportsBetting3.com Power Rankings - Louisville wound up with a 97.00 SportsBetting3.com conference power ranking for the 2025-26 college basketball regular season, while Michigan State finished with a 98.67 power ranking.
- Away Records - Tournament games are typically played at neutral venues, which means both teams are away from their home courts. Louisville comes to this matchup with a 4-7 record as an away team, ranking them 5th in the ACC Conference for away team wins. Their opponent, Michigan State, finished the regular season with a 6-4 record as an away team, ranking them 4th in the Big Ten Conference for away team wins.
- Conference Win Percentage - Louisville finished 5th (0.611) in the ACC Conference, with Michigan State ending up 2nd (0.750) for their conference win percentage in the 2025 Big Ten Conference.
- Overall Win Percentage - Louisville had a 0.706 regular season overall win percentage, with Michigan State notching a 0.788 overall win percentage at the end of the 2025-26 regular season.
- Team Records - Louisville tallied a 24-10 regular season overall record. Meanwhile, Michigan State put together a 26-7 standing for 2025-26 college basketball regular season.
Moneyline Mage
Spelling out the winners with humor since the middle ages.
Hocus pocus! Louisville 24-10 versus Michigan State 26-7. Magic madness on Saturday!
Louisville 11-7 ACC, Michigan State 15-5 Big Ten. Single-elimination showdown, winner moves on.
The tables below have the best point spread lines, total lines, and moneylines for this matchup. Bet on March Madness games at BetRivers and BetMGM. Review this matchup's prop bets below!
Best Cardinals at Spartans Odds
| Underdog Louisville | Favorite Michigan State |
|---|---|
| Over | Under |
|---|---|
| Underdog Louisville | Favorite Michigan State |
|---|---|
Matchup Odds FAQs
Michigan State is a -4.5 -115 point spread favorite at BetMGM, while Louisville is a +4.5 -105 point spread underdog at BetMGM.
The best over line is 151.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 151.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.
Michigan State is a -210 moneyline favorite at BetMGM and Louisville is a +170 moneyline underdog at BetMGM.
College Basketball Odds Example
|
Game |
 BetMGMBet |
|---|---|
Louisville
Michigan State
3/21/26 2:45pm EDT | +4.5 -105-4.5 -115 |
Underdog Louisville - Louisville bettors risk $100 to win $95.24 at -105 odds.
A +4.5 Louisville underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.
Favorite Michigan State - Michigan State bettors risk $100 to win $86.96 at -115 odds.
A -4.5 Michigan State favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.
Louisville at Michigan State Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Louisville
Michigan State
First to 5 Points
3/21/26 2:45pm EDT | -102-135Bet |
Louisville
Michigan State
First to 10 Points
3/21/26 2:45pm EDT | +105-145Bet |
Louisville
Michigan State
First to 15 Points
3/21/26 2:45pm EDT | +110-155Bet |
Louisville
Michigan State
Game to Overtime
3/21/26 2:45pm EDT | Yes +800No -3000Bet |
Team Standings
| Team | W-L | Win% | Home | Away | Conf | CGB | Conf% | Strk |
|---|---|---|---|---|---|---|---|---|
| ACC | ||||||||
| #23 Louisville | 24-11 | 0.686 | 15-2 | 4-7 | 11-7 | +6 | 0.611 | L1 |
| Big Ten | ||||||||
| #11 Michigan State | 27-8 | 0.771 | 15-2 | 6-4 | 15-5 | +4 | 0.750 | L1 |
Louisville & Michigan State Futures Odds
Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.
Louisville Championship OddsNo NCAA Men's Basketball Tournament TM Louisville YR: futures available
Michigan State Championship OddsNo NCAA Men's Basketball Tournament TM Michigan State YR: futures available
Louisville & Michigan State Team Pages
Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Louisville vs Michigan State College Basketball Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, March 21st, 2026 at 2:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Basketball page, look for the Louisville vs Michigan State Game.
Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Louisville vs Michigan State Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.