The Panthers will play the Bills on Saturday, August 15th, 2026. The matchup takes place at Highmark Stadium. Watch this exciting preseason matchup at 1:00 pm EDT.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's early in the 2026-27 NFL preseason for the Carolina Panthers and Buffalo Bills. Let's review some stats from the 2025 preseason to get an idea of how these teams will fare.
- SportsBetting3.com Power Rankings - The Carolina Panthers had a 87.00 power ranking in the 2025 preseason. The power ranking for the Buffalo Bills in the 2025 preseason was 89.00.
- Away Carolina Panthers - At the end of the 2025 preseason, the Carolina Panthers had a 0-1-0 record as an away team, ranking them 3rd in the preseason for away team wins.
- Home Buffalo Bills - The Buffalo Bills finished the 2025 preseason with a 0-1-0 record as a home team. They ranked 3rd for home team wins in the preseason standings.
- Points Scored - The Carolina Panthers wound up 26th (23) in the preseason, with the Buffalo Bills ranked 21st (48) for points scored in the 2025 preseason.
- Points Against - The Carolina Panthers finished 10th (69) in the preseason for points against in 2025. The Buffalo Bills wound up 4th (91) in the 2025 preseason for points against.
- Team Records - The Carolina Panthers had a 0-3-0 preseason record, with the Buffalo Bills notching a 1-2-0 preseason standing last year.
Best Panthers at Bills Odds
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NFL Odds Example
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Carolina Panthers at Buffalo Bills Prop Bets
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Panthers
Bills
8/15/26 1:00pm EDT | Pending |
Recent Meetings Since 2022
| Week | Game | Result | Margin |
|---|---|---|---|
| 2026 Preseason Week 1 | Panthers vs Bills Saturday, August 15th, 2026 | BUF 29, CAR 14 Highmark Stadium | Bills by 15 |
| 2025 Week 8 | Bills vs Panthers Sunday, October 26th, 2025 | BUF 40, CAR 9 Bank of America Stadium | Bills by 31 |
| 2024 Preseason Week 3 | Panthers vs Bills Saturday, August 24th, 2024 | CAR 31, BUF 26 Highmark Stadium | Panthers by 5 |
| 2022 Preseason Week 3 | Bills vs Panthers Friday, August 26th, 2022 | CAR 21, BUF 0 Bank of America Stadium | Panthers by 21 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| Buffalo Bills | 0 | 0 | 0 | 0.000 | 0 | 0 | 0-0-0 | 0-0-0 | 0-0-0 | 0.000 | 0-0-0 | 0.000 | 0 | - - |
| Carolina Panthers | 0 | 0 | 0 | 0.000 | 0 | 0 | 0-0-0 | 0-0-0 | 0-0-0 | 0.000 | 0-0-0 | 0.000 | 0 | - - |
Carolina Panthers & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Carolina Panthers Futures OddsNo Super Bowl TM Carolina Panthers YR: futures available
Buffalo Bills Futures OddsNo Super Bowl TM Buffalo Bills YR: futures available
Carolina Panthers & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Carolina Panthers vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, August 15th, 2026 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Carolina Panthers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other August 15, 2026 NFL Games
- Minnesota Vikings vs New York Giants - 8/15/26 1:00pm EDT
- Cleveland Browns vs Chicago Bears - 8/15/26 1:05pm EDT
- Los Angeles Rams vs Kansas City Chiefs - 8/15/26 4:00pm EDT
- Jacksonville Jaguars vs New Orleans Saints - 8/15/26 4:00pm EDT
- Philadelphia Eagles vs Baltimore Ravens - 8/15/26 7:00pm EDT
- Dallas Cowboys vs Seattle Seahawks - 8/15/26 8:04pm EDT