The American will play the National on Tuesday, July 15th, 2025. Your timezone's first pitch time is 8:23 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best American at National Odds
| Underdog American League | Favorite National League |
|---|---|
| Over | Under |
|---|---|
| Underdog National League | Favorite American League |
|---|---|
Matchup Odds FAQs
The National League are the -125 moneyline favorite at BetMGM and the American League are the +105 moneyline underdog at BetMGM.
The best over line is 6.5 -125 runs at BetMGM, which means you risk $125 to win $100 betting the over. The best under line is 6.5 +105 runs at BetMGM, and that means you risk $100 to win $105 betting the under.
The American League are -1.5 +180 run line favorites at BetMGM, while the National League are +1.5 -235 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
American
National
7/15/25 8:23pm EDT | +105-125 |
- American League bettors risk $100 to win $105 at +105 odds. The implied probability for American League is 48.78%.
- National League bettors risk $100 to win $80 at -125 odds. The implied probability for National League is 55.56%.
American League at National League Prop Bets
| BetMGM Bet |
|
|---|---|
American
National
First Team to Score
7/15/25 8:23pm EDT | -135+105Bet |
American
National
Tie
1st Inning Winner
7/15/25 8:23pm EDT | +400+375-200Bet |
American
National
Tie
First 3 Innings Winner
7/15/25 8:23pm EDT | +180+150+195Bet |
American
National
1st Team to Score Will Win
7/15/25 8:23pm EDT | Yes -250No +190Bet |
| BetMGM | |
Paul Skenes
Strikeouts Thrown
AL at NL 7/15/25 8:23pm EDT | 1.5 o +1301.5 u -170Bet |
Tarik Skubal
Strikeouts Thrown
AL at NL 7/15/25 8:23pm EDT | 1.5 o +1051.5 u -135Bet |
American League & National League Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
American League World Series OddsNo World Series TM American League YR: futures available
National League World Series OddsNo World Series TM National League YR: futures available
American League & National League Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
No standings available for American League and National League teams.
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the American League vs National League MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Tuesday, July 15th, 2025 at 8:23 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the American League vs National League Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the American League vs National League Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.