The White Sox will play the Guardians on Sunday, September 14th, 2025. Your timezone's first pitch time is 1:40 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best White Sox at Guardians Odds
| Underdog Chicago White Sox | Favorite Cleveland Guardians |
|---|---|
| Over | Under |
|---|---|
| Underdog Chicago White Sox | Favorite Cleveland Guardians |
|---|---|
Matchup Odds FAQs
The Cleveland Guardians are the -170 moneyline favorite at BetMGM and the Chicago White Sox are the +140 moneyline underdog at BetMGM.
The best over line is 8 +100 runs at BetMGM, which means you risk $100 to win $100 betting the over. The best under line is 8 -120 runs at BetMGM, and that means you risk $120 to win $100 betting the under.
The Cleveland Guardians are -1.5 +135 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -160 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
White Sox
Guardians
9/14/25 1:40pm EDT | +140-170 |
- Chicago White Sox bettors risk $100 to win $140 at +140 odds. The implied probability for Chicago White Sox is 41.67%.
- Cleveland Guardians bettors risk $100 to win $58.82 at -170 odds. The implied probability for Cleveland Guardians is 62.96%.
Chicago White Sox at Cleveland Guardians Prop Bets
| BetMGM Bet |
|
|---|---|
White Sox
Guardians
First Team to Score
9/14/25 1:40pm EDT | -135+105Bet |
White Sox
Guardians
Tie
1st Inning Winner
9/14/25 1:40pm EDT | +325+280-140Bet |
White Sox
Guardians
Tie
First 3 Innings Winner
9/14/25 1:40pm EDT | +165+125+280Bet |
White Sox
Guardians
To Extra Innings
9/14/25 1:40pm EDT | Yes +750No -1200Bet |
| BetMGM | |
White Sox
Guardians
1st Team to Score Will Win
9/14/25 1:40pm EDT | Yes -250No +190Bet |
Guardians
Total Runs
CWS at CLE 9/14/25 1:40pm EDT | 4.5 o +1104.5 u -145Bet |
Slade Cecconi
Strikeouts Thrown
CWS at CLE 9/14/25 1:40pm EDT | 4.5 o -1104.5 u -120Bet |
Yoendrys Gomez
Strikeouts Thrown
CWS at CLE 9/14/25 1:40pm EDT | 4.5 o -1354.5 u +105Bet |
Chicago White Sox & Cleveland Guardians Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Chicago White Sox World Series OddsNo World Series TM Chicago White Sox YR: futures available
Cleveland Guardians World Series Odds|
Team | BetMGM |
|---|---|
| Guardians | +20000 Bet |
Chicago White Sox & Cleveland Guardians Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleveland Guardians | 78 | 71 | 0.523 | +12.5 | 41-34 | 37-37 | 580 | 611 | -31 | W4 | 9-1 |
| e - Chicago White Sox | 57 | 94 | 0.377 | +34.5 | 32-44 | 25-50 | 601 | 687 | -86 | L4 | 4-6 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Chicago White Sox vs Cleveland Guardians MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 14th, 2025 at 1:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Chicago White Sox vs Cleveland Guardians Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs Cleveland Guardians Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 14, 2025 MLB Games
- Pittsburgh Pirates vs Washington Nationals - 9/14/25 11:35am EDT
- Houston Astros vs Atlanta Braves - 9/14/25 1:35pm EDT
- Kansas City Royals vs Philadelphia Phillies - 9/14/25 1:35pm EDT
- Baltimore Orioles vs Toronto Blue Jays - 9/14/25 1:37pm EDT
- Texas Rangers vs New York Mets - 9/14/25 1:40pm EDT
- Detroit Tigers vs Miami Marlins - 9/14/25 1:40pm EDT
- Arizona Diamondbacks vs Minnesota Twins - 9/14/25 2:10pm EDT
- St. Louis Cardinals vs Milwaukee Brewers - 9/14/25 2:10pm EDT
- Tampa Bay Rays vs Chicago Cubs - 9/14/25 2:20pm EDT
- Los Angeles Dodgers vs San Francisco Giants - 9/14/25 4:05pm EDT
- Cincinnati Reds vs Oakland Athletics - 9/14/25 4:05pm EDT
- Colorado Rockies vs San Diego Padres - 9/14/25 4:10pm EDT
- Los Angeles Angels vs Seattle Mariners - 9/14/25 4:10pm EDT
- New York Yankees vs Boston Red Sox - 9/14/25 7:10pm EDT