The White Sox will play the Guardians on Wednesday, September 16th, 2026. Your timezone's first pitch time is 1:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best White Sox at Guardians Odds
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MLB Odds Example
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Chicago White Sox at Cleveland Guardians Prop Bets
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White Sox
Guardians
9/16/26 1:10pm EDT | Pending |
Chicago White Sox & Cleveland Guardians Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Chicago White Sox World Series OddsNo World Series TM Chicago White Sox YR: futures available
Cleveland Guardians World Series OddsNo World Series TM Cleveland Guardians YR: futures available
Chicago White Sox & Cleveland Guardians Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
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| Cleveland Guardians | 81 | 75 | 0.519 | +16.5 | 41-40 | 40-35 | 649 | 647 | +2 | W5 | 7-3 |
| Chicago White Sox | 80 | 76 | 0.513 | +17.5 | 46-32 | 34-44 | 733 | 691 | +42 | W2 | 5-5 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Chicago White Sox vs Cleveland Guardians MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 16th, 2026 at 1:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Chicago White Sox vs Cleveland Guardians Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs Cleveland Guardians Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 16, 2026 MLB Games
- San Francisco Giants vs St. Louis Cardinals - 9/16/26 1:17pm EDT
- New York Yankees vs Minnesota Twins - 9/16/26 1:40pm EDT
- Detroit Tigers vs Toronto Blue Jays - 9/16/26 3:07pm EDT
- Milwaukee Brewers vs Pittsburgh Pirates - 9/16/26 6:40pm EDT
- Los Angeles Dodgers vs Cincinnati Reds - 9/16/26 6:40pm EDT
- Oakland Athletics vs Tampa Bay Rays - 9/16/26 6:40pm EDT
- Philadelphia Phillies vs Washington Nationals - 9/16/26 6:45pm EDT
- Baltimore Orioles vs New York Mets - 9/16/26 7:10pm EDT
- Atlanta Braves vs Chicago Cubs - 9/16/26 7:40pm EDT
- Kansas City Royals vs Houston Astros - 9/16/26 8:12pm EDT
- Boston Red Sox vs Texas Rangers - 9/16/26 8:13pm EDT
- San Diego Padres vs Colorado Rockies - 9/16/26 8:40pm EDT
- Seattle Mariners vs Los Angeles Angels - 9/16/26 9:38pm EDT
- Miami Marlins vs Arizona Diamondbacks - 9/16/26 9:40pm EDT