The Reds will play the Pirates on Wednesday, May 21st, 2025. Your timezone's first pitch time is 12:35 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - As the 2025 season continues, the Cincinnati Reds possess a 93.67 SportsBetting3.com power ranking. The Pittsburgh Pirates now have a 86.33 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
- Visiting Cincinnati Reds - The Cincinnati Reds head into this matchup with a 12-13 record as a visiting team. This standing ranks them 3rd Overall for visiting team wins.
- Home Pittsburgh Pirates - The Pittsburgh Pirates will throw the first pitch possessing a 10-14 home team record. That puts them 7th for home team wins in the Overall MLB standings.
- Runs Scored - Cincinnati Reds batters have produced 227 runs, ranking them 8th Overall, with the Pittsburgh Pirates ranking 28th (143) for runs scored.
- Runs Allowed - Cincinnati Reds pitchers and fielders have allowed 192 runs, ranking them 16th Overall for runs allowed. Meanwhile, the Pittsburgh Pirates now rank 10th Overall, allowing 210 runs.
- Team Streaks - The Cincinnati Reds lost their last game. Their opponent, the Pittsburgh Pirates won their last game.
- Team Records - Let's review each team's records. The Cincinnati Reds have a 25-25 Overall record (4.5 GB National Central Division), with the Pittsburgh Pirates notching a 16-33 Overall standing (13.0 GB National Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast, ye scallywags! The Reds be takin' on the pathetic Pirates...
Cincinnati be lookin' to plunder a victory on enemy shores...
The Pirates be walkin' the plank with their abysmal record...
The Reds be ready to hoist the Jolly Roger in victory! (Arrr!)...
Check out this game's prop bets below, bet on MLB baseball at legal US sportsbooks, and review each team's standing at the bottom of the page.
Best Reds at Pirates Odds
| Underdog Pittsburgh Pirates | Favorite Cincinnati Reds |
|---|---|
| Over | Under |
|---|---|
| Underdog Pittsburgh Pirates | Favorite Cincinnati Reds |
|---|---|
Matchup Odds FAQs
The Cincinnati Reds are the -125 moneyline favorite at BetMGM and the Pittsburgh Pirates are the +105 moneyline underdog at BetMGM.
The best over line is 8 -102 runs at BetMGM, which means you risk $102 to win $100 betting the over. The best under line is 8 -118 runs at BetMGM, and that means you risk $118 to win $100 betting the under.
The Cincinnati Reds are -1.5 +135 run line favorites at BetMGM, while the Pittsburgh Pirates are +1.5 -160 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Reds
Pirates
5/21/25 12:35pm EDT | -125+105 |
- Pittsburgh Pirates bettors risk $100 to win $105 at +105 odds. The implied probability for Pittsburgh Pirates is 48.78%.
- Cincinnati Reds bettors risk $100 to win $80 at -125 odds. The implied probability for Cincinnati Reds is 55.56%.
Cincinnati Reds at Pittsburgh Pirates Prop Bets
| BetMGM Bet |
|
|---|---|
Reds
Pirates
First Team to Score
5/21/25 12:35pm EDT | -175+135Bet |
Reds
Pirates
Tie
1st Inning Winner
5/21/25 12:35pm EDT | +275+340-145Bet |
Reds
Pirates
Tie
First 3 Innings Winner
5/21/25 12:35pm EDT | +125+165+250Bet |
Reds
Pirates
To Extra Innings
5/21/25 12:35pm EDT | Yes +700No -1100Bet |
| BetMGM | |
Reds
Pirates
1st Team to Score Will Win
5/21/25 12:35pm EDT | Yes -250No +190Bet |
Reds
Total Runs
CIN at PIT 5/21/25 12:35pm EDT | 4.5 o +1154.5 u -150Bet |
Pirates
Total Runs
CIN at PIT 5/21/25 12:35pm EDT | 3.5 o -1103.5 u -115Bet |
Andrew Heaney
Strikeouts Thrown
CIN at PIT 5/21/25 12:35pm EDT | 4.5 o -1154.5 u -115Bet |
| BetMGM | |
Brady Singer
Strikeouts Thrown
CIN at PIT 5/21/25 12:35pm EDT | 4.5 o -1504.5 u +115Bet |
Cincinnati Reds & Pittsburgh Pirates Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cincinnati Reds World Series Odds|
Team | BetMGM |
|---|---|
| Reds | +12500 Bet |
|
Team | BetMGM |
|---|---|
| Pirates | +50000 Bet |
Cincinnati Reds & Pittsburgh Pirates Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cincinnati Reds | 27 | 28 | 0.491 | +8.5 | 14-14 | 13-14 | 255 | 227 | +28 | W1 | 6-4 |
| Pittsburgh Pirates | 19 | 36 | 0.345 | +16.5 | 13-16 | 6-20 | 164 | 236 | -72 | L2 | 4-6 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cincinnati Reds vs Pittsburgh Pirates MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 12:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cincinnati Reds vs Pittsburgh Pirates Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cincinnati Reds vs Pittsburgh Pirates Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 21, 2025 MLB Games
- Baltimore Orioles vs Milwaukee Brewers
- Chicago Cubs vs Miami Marlins
- Houston Astros vs Tampa Bay Rays
- Detroit Tigers vs St. Louis Cardinals
- Seattle Mariners vs Chicago White Sox
- Cleveland Guardians vs Minnesota Twins
- Kansas City Royals vs San Francisco Giants
- New York Mets vs Boston Red Sox
- Atlanta Braves vs Washington Nationals
- Texas Rangers vs New York Yankees
- San Diego Padres vs Toronto Blue Jays
- Cleveland Guardians vs Minnesota Twins
- Philadelphia Phillies vs Colorado Rockies
- Los Angeles Angels vs Oakland Athletics
- Arizona Diamondbacks vs Los Angeles Dodgers