Cleveland Guardians vs Arizona Diamondbacks Odds

The Guardians will play the Diamondbacks on Wednesday, August 20th, 2025. Your timezone's first pitch time is 3:40 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Best Guardians at Diamondbacks Odds


Best Moneyline Betting Odds
Underdog

Cleveland Guardians
Favorite

Arizona Diamondbacks
The Arizona Diamondbacks are the -120 moneyline favorite. Risk $120 to win $100 on the Arizona Diamondbacks at BetMGM. The Cleveland Guardians are the +100 underdog at BetMGM. Risk $100 to win $100 on the Cleveland Guardians. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 9 runs. Risk $120 to win $100. BetMGM has the best under line of 9 runs. Risk $100 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Arizona Diamondbacks
Favorite

Cleveland Guardians
The Cleveland Guardians have a -1.5 +165 run line at BetMGM OH. They are the run line favorite in this matchup. The Arizona Diamondbacks have a +1.5 -200 run line at BetMGM OH. The Arizona Diamondbacks are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Cleveland Guardians vs Arizona Diamondbacks MLB game on Wednesday, August 20th, 2025?

The Arizona Diamondbacks are the -120 moneyline favorite at BetMGM and the Cleveland Guardians are the +100 moneyline underdog at BetMGM.

What is the over-under total line for the Cleveland Guardians vs Arizona Diamondbacks MLB game on Wednesday, August 20th, 2025?

The best over line is 9 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 9 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.

What is the run line for the Cleveland Guardians vs Arizona Diamondbacks MLB game on Wednesday, August 20th, 2025?

The Cleveland Guardians are -1.5 +165 run line favorites at BetMGM, while the Arizona Diamondbacks are +1.5 -200 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Guardians
Diamondbacks
8/20/25 3:40pm EDT
+100-120
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
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Possible Moneyline Outcomes
  • Cleveland Guardians bettors risk $100 to win $100 at +100 odds. The implied probability for Cleveland Guardians is 50%.
  • Arizona Diamondbacks bettors risk $100 to win $83.33 at -120 odds. The implied probability for Arizona Diamondbacks is 54.55%.

Cleveland Guardians at Arizona Diamondbacks Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Guardians
Diamondbacks
First Team to Score
8/20/25 3:40pm EDT
-150+118Bet
Guardians
Diamondbacks
Tie
1st Inning Winner
8/20/25 3:40pm EDT
+290+240-110Bet
Guardians
Diamondbacks
Tie
First 3 Innings Winner
8/20/25 3:40pm EDT
+150+115+350Bet
Guardians
Diamondbacks
To Extra Innings
8/20/25 3:40pm EDT
Yes +825No -1400Bet
BetMGM Sports Betting BetMGM
Guardians
Diamondbacks
1st Team to Score Will Win
8/20/25 3:40pm EDT
Yes -250No +190Bet
Diamondbacks
Total Runs
CLE at ARI
8/20/25 3:40pm EDT
4.5 o -1104.5 u -118Bet
Guardians
Total Runs
CLE at ARI
8/20/25 3:40pm EDT
4.5 o -1104.5 u -118Bet
Brandon Pfaadt
Strikeouts Thrown
CLE at ARI
8/20/25 3:40pm EDT
4.5 o -1104.5 u -118Bet

Cleveland Guardians & Arizona Diamondbacks Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds
2025 Cleveland Guardians World Series Odds

Team
BetMGM Sports Betting BetMGM
Guardians
+30000
Bet
Arizona Diamondbacks World Series Odds
2025 Arizona Diamondbacks World Series Odds

Team
BetMGM Sports Betting BetMGM
Diamondbacks
+100000
Bet

Cleveland Guardians & Arizona Diamondbacks Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Cleveland Guardians, Arizona Diamondbacks
Team W L Pct GB Home Away RS RA Diff Strk L10
Cleveland Guardians66660.500+15.533-3233-34508563-55W23-7
Arizona Diamondbacks66690.489+17.034-3232-37667657+10W26-4

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Cleveland Guardians vs Arizona Diamondbacks MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, August 20th, 2025 at 3:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Arizona Diamondbacks Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Arizona Diamondbacks Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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