Cleveland Guardians vs Chicago White Sox Odds

The Guardians will play the White Sox on Wednesday, June 24th, 2026. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - As the 2026 season continues, the Cleveland Guardians possess a 91.67 SportsBetting3.com power ranking. The Chicago White Sox now have a 93.00 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
  • Visiting Cleveland Guardians - The Cleveland Guardians head into this matchup with a 22-21 record as a visiting team. This standing ranks them 2nd Overall for visiting team wins.
  • Home Chicago White Sox - The Chicago White Sox will throw the first pitch possessing a 25-12 home team record. That puts them 2nd for home team wins in the Overall MLB standings.
  • Runs Scored - Cleveland Guardians batters have produced 315 runs, ranking them 23rd Overall, with the Chicago White Sox ranking 12th (359) for runs scored.
  • Runs Allowed - Cleveland Guardians pitchers and fielders have allowed 323 runs, ranking them 20th Overall for runs allowed. Meanwhile, the Chicago White Sox now rank 12th Overall, allowing 362 runs.
  • Team Streaks - The Cleveland Guardians have lost their last 2 games. Their opponent, the Chicago White Sox won their last game.
  • Team Records - Let's review each team's records. The Cleveland Guardians have a 41-38 Overall record (0.0 GB American Central Division), with the Chicago White Sox notching a 40-37 Overall standing (1.0 GB American Central Division).

Best Guardians at White Sox Odds


Best Moneyline Betting Odds
Underdog

Chicago White Sox
Favorite

Cleveland Guardians
The Cleveland Guardians are the -125 moneyline favorite. Risk $125 to win $100 on the Cleveland Guardians at BetMGM. The Chicago White Sox are the +105 underdog at BetMGM. Risk $100 to win $105 on the Chicago White Sox. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8.5 runs. Risk $110 to win $100. BetMGM has the best under line of 8.5 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Chicago White Sox
Favorite

Cleveland Guardians
The Cleveland Guardians have a -1.5 +135 run line at BetMGM OH. They are the run line favorite in this matchup. The Chicago White Sox have a +1.5 -165 run line at BetMGM OH. The Chicago White Sox are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Cleveland Guardians vs Chicago White Sox MLB game on Wednesday, June 24th, 2026?

The Cleveland Guardians are the -125 moneyline favorite at BetMGM and the Chicago White Sox are the +105 moneyline underdog at BetMGM.

What is the over-under total line for the Cleveland Guardians vs Chicago White Sox MLB game on Wednesday, June 24th, 2026?

The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the Cleveland Guardians vs Chicago White Sox MLB game on Wednesday, June 24th, 2026?

The Cleveland Guardians are -1.5 +135 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -165 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Guardians
White Sox
6/24/26 2:10pm EDT
-125+105
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • Chicago White Sox bettors risk $100 to win $105 at +105 odds. The implied probability for Chicago White Sox is 48.78%.
  • Cleveland Guardians bettors risk $100 to win $80 at -125 odds. The implied probability for Cleveland Guardians is 55.56%.

Cleveland Guardians at Chicago White Sox Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Guardians
White Sox
6/24/26 2:10pm EDT
Pending BetMGM

Cleveland Guardians & Chicago White Sox Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds
2026 Cleveland Guardians World Series Odds

Team
BetMGM Sports Betting BetMGM
Guardians
+3500
Bet
Chicago White Sox World Series Odds
2026 Chicago White Sox World Series Odds

Team
BetMGM Sports Betting BetMGM
White Sox
+4000
Bet

Cleveland Guardians & Chicago White Sox Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - Cleveland Guardians, Chicago White Sox
Team W L Pct GB Home Away RS RA Diff Strk L10
Chicago White Sox43380.531+9.028-1315-25388369+19W25-5
Cleveland Guardians43400.518+10.020-1823-22325334-9W14-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Cleveland Guardians vs Chicago White Sox MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, June 24th, 2026 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Chicago White Sox Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Chicago White Sox Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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