The Guardians will play the White Sox on Thursday, March 5th, 2026. Your timezone's first pitch time is 8:05 pm EST. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Guardians at White Sox Odds
| Underdog Cleveland Guardians | Favorite Chicago White Sox |
|---|---|
| Over | Under |
|---|---|
| Underdog Cleveland Guardians | Favorite Chicago White Sox |
|---|---|
Matchup Odds FAQs
The Chicago White Sox are the -110 moneyline favorite at BetMGM and the Cleveland Guardians are the -110 moneyline underdog at BetMGM.
The best over line is 12.5 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 12.5 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.
The Chicago White Sox are -1.5 +155 run line favorites at BetMGM, while the Cleveland Guardians are +1.5 -190 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Guardians
White Sox
3/05/26 8:05pm EST | -110-110 |
- Cleveland Guardians bettors risk $100 to win $90.91 at -110 odds. The implied probability for Cleveland Guardians is 52.38%.
- Chicago White Sox bettors risk $100 to win $90.91 at -110 odds. The implied probability for Chicago White Sox is 52.38%.
Cleveland Guardians at Chicago White Sox Prop Bets
| BetMGM Bet |
|
|---|---|
Guardians
White Sox
3/05/26 8:05pm EST | Pending BetMGM |
Cleveland Guardians & Chicago White Sox Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cleveland Guardians World Series Odds|
Team | BetMGM |
|---|---|
| Guardians | +6600 Bet |
|
Team | BetMGM |
|---|---|
| White Sox | +40000 Bet |
Cleveland Guardians & Chicago White Sox Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleveland Guardians | 2 | 1 | 0.667 | +1.0 | 0-0 | 2-1 | 13 | 14 | -1 | W1 | 2-1 |
| Chicago White Sox | 0 | 3 | 0.000 | +3.0 | 0-0 | 0-3 | 10 | 29 | -19 | L3 | 0-3 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cleveland Guardians vs Chicago White Sox MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, March 5th, 2026 at 8:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Chicago White Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Chicago White Sox Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other March 5, 2026 MLB Games
- Toronto Blue Jays vs Atlanta Braves
- Minnesota Twins vs New York Yankees
- Boston Red Sox vs Philadelphia Phillies
- St. Louis Cardinals vs Pittsburgh Pirates
- Baltimore Orioles vs Tampa Bay Rays
- New York Mets vs Washington Nationals
- Houston Astros vs Miami Marlins
- Los Angeles Dodgers vs Cincinnati Reds
- Arizona Diamondbacks vs Chicago Cubs
- Milwaukee Brewers vs Colorado Rockies
- Oakland Athletics vs Los Angeles Angels
- San Diego Padres vs Seattle Mariners
- Texas Rangers vs Kansas City Royals