The Guardians will play the Tigers on Thursday, September 18th, 2025. Your timezone's first pitch time is 1:10 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Guardians at Tigers Odds
| Underdog Cleveland Guardians | Favorite Detroit Tigers |
|---|---|
| Over | Under |
|---|---|
| Underdog Cleveland Guardians | Favorite Detroit Tigers |
|---|---|
Matchup Odds FAQs
The Detroit Tigers are the -200 moneyline favorite at BetMGM and the Cleveland Guardians are the +165 moneyline underdog at BetMGM.
The best over line is 7 -125 runs at BetMGM, which means you risk $125 to win $100 betting the over. The best under line is 7 +105 runs at BetMGM, and that means you risk $100 to win $105 betting the under.
The Detroit Tigers are -1.5 +110 run line favorites at BetMGM, while the Cleveland Guardians are +1.5 -135 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Guardians
Tigers
1:10pm EDT | +165-200 |
- Cleveland Guardians bettors risk $100 to win $165 at +165 odds. The implied probability for Cleveland Guardians is 37.74%.
- Detroit Tigers bettors risk $100 to win $50 at -200 odds. The implied probability for Detroit Tigers is 66.67%.
Cleveland Guardians at Detroit Tigers Prop Bets
| BetMGM Bet |
|
|---|---|
Guardians
Tigers
First Team to Score
1:10pm EDT | +105-135Bet |
Guardians
Tigers
Tie
1st Inning Winner
1:10pm EDT | +450+270-165Bet |
Guardians
Tigers
Tie
First 3 Innings Winner
1:10pm EDT | +230+105+230Bet |
Guardians
Tigers
To Extra Innings
1:10pm EDT | Yes +700No -1100Bet |
| BetMGM | |
Guardians
Tigers
1st Team to Score Will Win
1:10pm EDT | Yes -250No +190Bet |
Guardians
Total Runs
CLE at DET 1:10pm EDT | 2.5 o -1452.5 u +110Bet |
Tigers
Total Runs
CLE at DET 1:10pm EDT | 4.5 o +1154.5 u -150Bet |
Tanner Bibee
Strikeouts Thrown
CLE at DET 1:10pm EDT | 5.5 o +1055.5 u -140Bet |
| BetMGM | |
Tarik Skubal
Strikeouts Thrown
CLE at DET 1:10pm EDT | 7.5 o +1107.5 u -145Bet |
Cleveland Guardians & Detroit Tigers Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cleveland Guardians World Series Odds|
Team | BetMGM |
|---|---|
| Guardians | +10000 Bet |
|
Team | BetMGM |
|---|---|
| Tigers | +1000 Bet |
Cleveland Guardians & Detroit Tigers Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Detroit Tigers | 85 | 66 | 0.563 | +7.0 | 46-30 | 39-36 | 734 | 641 | +93 | L1 | 4-6 |
| Cleveland Guardians | 79 | 71 | 0.527 | +12.5 | 41-34 | 38-37 | 587 | 616 | -29 | W5 | 9-1 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cleveland Guardians vs Detroit Tigers MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 18th, 2025 at 1:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Detroit Tigers Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Detroit Tigers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 18, 2025 MLB Games
- San Diego Padres vs New York Mets - 1:10pm EDT
- Toronto Blue Jays vs Tampa Bay Rays - 1:10pm EDT
- Oakland Athletics vs Boston Red Sox - 1:35pm EDT
- Seattle Mariners vs Kansas City Royals - 2:10pm EDT
- Miami Marlins vs Colorado Rockies - 3:10pm EDT
- New York Yankees vs Baltimore Orioles - 7:15pm EDT
- Chicago Cubs vs Cincinnati Reds - 7:15pm EDT
- Los Angeles Angels vs Milwaukee Brewers - 7:40pm EDT
- San Francisco Giants vs Los Angeles Dodgers - 10:10pm EDT