The Guardians will play the Cardinals on Wednesday, April 15th, 2026. Your timezone's first pitch time is 1:15 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Cleveland Guardians have a 93.00 power ranking. The power ranking for the St. Louis Cardinals is 90.00.
- Visiting Cleveland Guardians - The Cleveland Guardians have a 6-6 record as a visiting team, ranking them 2nd Overall for visiting team wins.
- Home St. Louis Cardinals - The St. Louis Cardinals have a 6-5 record as a home team. They rank 3rd for home team wins in the Overall standings.
- Runs Scored - The Cleveland Guardians currently stand 14th (72) Overall, with the St. Louis Cardinals ranking 13th (75) for runs scored.
- Runs Allowed - The Cleveland Guardians are 13th (76) Overall for runs allowed. The St. Louis Cardinals stand 3rd (94) for runs allowed.
- Team Streaks - The Cleveland Guardians lost their last game. Meanwhile, the St. Louis Cardinals won their last game.
- Team Records - The Cleveland Guardians have a 10-8 Overall record (1.0 GB American Central Division), with the St. Louis Cardinals possessing a 9-8 Overall standing (1.0 GB National Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Cleveland Guardians be facing the St. Louis Cardinals on Wednesday...
Arrr, the Guardians be sailin' into enemy waters with a 10-8 record... (SportsBetting3.com)
Batten down the hatches and bet on this game, ye landlubbers! Review the odds below...
The Cardinals be holdin' a 9-8 record at home, ready to defend their turf... (SportsBetting3.com)
But fear not, me hearties, for the Guardians be ready for battle with a 0.556 win percentage...
It be a clash of titans on the diamond, so grab yer parrot and... (SportsBetting3.com)
Set sail for victory as the Guardians look to plunder a win in St. Louis... (SportsBetting3.com)
So hoist the Jolly Roger and bet on this showdown of baseball brigands... (SportsBetting3.com)
May the wind be at the Guardians' backs as they seek to pillage a victory... (SportsBetting3.com)
Best Guardians at Cardinals Odds
| Underdog Cleveland Guardians | Favorite St. Louis Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite Cleveland Guardians |
|---|---|
Matchup Odds FAQs
The St. Louis Cardinals are the -117 moneyline favorite at BetRivers and the Cleveland Guardians are the -107 moneyline underdog at BetRivers.
The best over line is 9 -108 runs at BetRivers, which means you risk $108 to win $100 betting the over. The best under line is 9 -115 runs at BetRivers, and that means you risk $115 to win $100 betting the under.
The Cleveland Guardians are -1.5 +160 run line favorites at BetRivers, while the St. Louis Cardinals are +1.5 -200 run line underdogs at BetRivers.
MLB Odds Example
|
Game |
 BetRiversBet |
|---|---|
Guardians
Cardinals
4/15/26 1:15pm EDT | -107-117 |
- Cleveland Guardians bettors risk $100 to win $93.46 at -107 odds. The implied probability for Cleveland Guardians is 51.69%.
- St. Louis Cardinals bettors risk $100 to win $85.47 at -117 odds. The implied probability for St. Louis Cardinals is 53.92%.
Cleveland Guardians at St. Louis Cardinals Prop Bets
| BetRivers Bet |
|
|---|---|
Guardians
Cardinals
Tie
1st Inning Winner
4/15/26 1:15pm EDT | +300+245-118Bet |
Guardians
Cardinals
Tie
First 3 Innings Winner
4/15/26 1:15pm EDT | +155+120+300Bet |
Guardians
Total Runs
CLE at STL 4/15/26 1:15pm EDT | 4.5 o +1004.5 u -125Bet |
Cardinals
Total Runs
CLE at STL 4/15/26 1:15pm EDT | 4.5 o +1004.5 u -129Bet |
| BetRivers | |
Dustin May
Strikeouts Thrown
CLE at STL 4/15/26 1:15pm EDT | 3.5 o -1483.5 u +110Bet |
Slade Cecconi
Strikeouts Thrown
CLE at STL 4/15/26 1:15pm EDT | 4.5 o +1154.5 u -152Bet |
Cleveland Guardians & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cleveland Guardians World Series Odds|
Team | BetRivers |
|---|---|
| Guardians | +3500 Bet |
No World Series TM St. Louis Cardinals YR: futures available
Cleveland Guardians & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| x - Cleveland Guardians | 85 | 77 | 0.525 | +18.0 | 41-40 | 44-37 | 678 | 667 | +11 | L1 | 8-2 |
| e - St. Louis Cardinals | 77 | 85 | 0.475 | +26.0 | 38-43 | 39-42 | 720 | 749 | -29 | L4 | 2-8 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cleveland Guardians vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 15th, 2026 at 1:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other April 15, 2026 MLB Games
- Arizona Diamondbacks vs Baltimore Orioles
- Boston Red Sox vs Minnesota Twins
- San Francisco Giants vs Cincinnati Reds
- Kansas City Royals vs Detroit Tigers
- Chicago Cubs vs Philadelphia Phillies
- Washington Nationals vs Pittsburgh Pirates
- Los Angeles Angels vs New York Yankees
- Miami Marlins vs Atlanta Braves
- Tampa Bay Rays vs Chicago White Sox
- Toronto Blue Jays vs Milwaukee Brewers
- Colorado Rockies vs Houston Astros
- Texas Rangers vs Oakland Athletics
- Seattle Mariners vs San Diego Padres
- New York Mets vs Los Angeles Dodgers