Los Angeles Angels vs San Diego Padres Odds

The Angels will play the Padres on Wednesday, February 25th, 2026. Your timezone's first pitch time is 3:10 pm EST. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Best Angels at Padres Odds


Best Moneyline Betting Odds
Underdog

Los Angeles Angels
Favorite

San Diego Padres
The San Diego Padres are the -155 moneyline favorite. Risk $155 to win $100 on the San Diego Padres at BetMGM. The Los Angeles Angels are the +130 underdog at BetMGM. Risk $100 to win $130 on the Los Angeles Angels. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 11.5 runs. Risk $105 to win $100. BetMGM has the best under line of 11.5 runs. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Los Angeles Angels
Favorite

San Diego Padres
The San Diego Padres have a -1.5 +115 run line at BetMGM OH. They are the run line favorite in this matchup. The Los Angeles Angels have a +1.5 -135 run line at BetMGM OH. The Los Angeles Angels are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Los Angeles Angels vs San Diego Padres MLB game on Wednesday, February 25th, 2026?

The San Diego Padres are the -155 moneyline favorite at BetMGM and the Los Angeles Angels are the +130 moneyline underdog at BetMGM.

What is the over-under total line for the Los Angeles Angels vs San Diego Padres MLB game on Wednesday, February 25th, 2026?

The best over line is 11.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 11.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the run line for the Los Angeles Angels vs San Diego Padres MLB game on Wednesday, February 25th, 2026?

The San Diego Padres are -1.5 +115 run line favorites at BetMGM, while the Los Angeles Angels are +1.5 -135 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Angels
Padres
3:10pm EST
+130-155
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Possible Moneyline Outcomes
  • Los Angeles Angels bettors risk $100 to win $130 at +130 odds. The implied probability for Los Angeles Angels is 43.48%.
  • San Diego Padres bettors risk $100 to win $64.52 at -155 odds. The implied probability for San Diego Padres is 60.78%.

Los Angeles Angels at San Diego Padres Prop Bets

MLB Prop Bets
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Angels
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3:10pm EST
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Los Angeles Angels & San Diego Padres Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Los Angeles Angels World Series Odds
2026 Los Angeles Angels World Series Odds

Team
BetMGM Sports Betting BetMGM
Angels
+25000
Bet
San Diego Padres World Series Odds
2026 San Diego Padres World Series Odds

Team
BetMGM Sports Betting BetMGM
Padres
+2800
Bet

Los Angeles Angels & San Diego Padres Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Los Angeles Angels, San Diego Padres
Team W L Pct GB Home Away RS RA Diff Strk L10
y - San Diego Padres90720.556+7.052-2938-43702621+81W37-3
e - Los Angeles Angels72900.444+25.039-4233-48673837-164L23-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Los Angeles Angels vs San Diego Padres MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, February 25th, 2026 at 3:10 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Los Angeles Angels vs San Diego Padres Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Los Angeles Angels vs San Diego Padres Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other February 25, 2026 MLB Games

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