San Diego Padres vs Chicago White Sox Odds

The Padres will play the White Sox on Sunday, September 21st, 2025. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Padres at White Sox Odds

**Best Moneyline Betting Odds**
Underdog Chicago White Sox	Favorite San Diego Padres
+155 BetMGM Bet	-190 BetMGM Bet

The San Diego Padres are the -190 moneyline favorite. Risk $190 to win $100 on the San Diego Padres at BetMGM. The Chicago White Sox are the +155 underdog at BetMGM. Risk $100 to win $155 on the Chicago White Sox. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8 o -110 BetMGM Bet	8 u -110 BetMGM Bet

BetMGM has the best over line of 8 runs. Risk $110 to win $100. BetMGM has the best under line of 8 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Chicago White Sox	Favorite San Diego Padres
+1.5 -110 BetMGM Bet	-1.5 -110 BetMGM Bet

The San Diego Padres have a -1.5 -110 run line at BetMGM OH. They are the run line favorite in this matchup. The Chicago White Sox have a +1.5 -110 run line at BetMGM OH. The Chicago White Sox are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Diego Padres vs Chicago White Sox MLB game on Sunday, September 21st, 2025?

The San Diego Padres are the -190 moneyline favorite at BetMGM and the Chicago White Sox are the +155 moneyline underdog at BetMGM.

What is the over-under total line for the San Diego Padres vs Chicago White Sox MLB game on Sunday, September 21st, 2025?

The best over line is 8 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the San Diego Padres vs Chicago White Sox MLB game on Sunday, September 21st, 2025?

The San Diego Padres are -1.5 -110 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -110 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Padres White Sox 9/21/25 2:10pm EDT	-190 +155

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Possible Moneyline Outcomes

Chicago White Sox bettors risk $100 to win $155 at +155 odds. The implied probability for Chicago White Sox is 39.22%.
San Diego Padres bettors risk $100 to win $52.63 at -190 odds. The implied probability for San Diego Padres is 65.52%.

San Diego Padres at Chicago White Sox Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Padres White Sox First Team to Score 9/21/25 2:10pm EDT	-200 +155 Bet
Padres White Sox Tie 1st Inning Winner 9/21/25 2:10pm EDT	+250 +360 -140 Bet
Padres White Sox Tie First 3 Innings Winner 9/21/25 2:10pm EDT	+110 +185 +280 Bet
Padres White Sox To Extra Innings 9/21/25 2:10pm EDT	Yes +750 No -1200 Bet
	BetMGM
Padres White Sox 1st Team to Score Will Win 9/21/25 2:10pm EDT	Yes -250 No +190 Bet
Padres Total Runs SDG at CWS 9/21/25 2:10pm EDT	4.5 o -118 4.5 u -110 Bet
Michael King Strikeouts Thrown SDG at CWS 9/21/25 2:10pm EDT	4.5 o -135 4.5 u +100 Bet
Sean Burke Strikeouts Thrown SDG at CWS 9/21/25 2:10pm EDT	4.5 o +130 4.5 u -175 Bet

San Diego Padres & Chicago White Sox Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Diego Padres World Series Odds

No World Series TM San Diego Padres YR: futures available

Chicago White Sox World Series Odds

No World Series TM Chicago White Sox YR: futures available

San Diego Padres & Chicago White Sox Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Diego Padres, Chicago White Sox
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - San Diego Padres	90	72	0.556	+7.0	52-29	38-43	702	621	+81	W3	7-3
e - Chicago White Sox	60	102	0.370	+37.0	33-48	27-54	647	742	-95	W1	3-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Diego Padres vs Chicago White Sox MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the San Diego Padres vs Chicago White Sox Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Diego Padres vs Chicago White Sox Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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