The Giants will play the Diamondbacks on Wednesday, September 17th, 2025. Your timezone's first pitch time is 3:40 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Giants at Diamondbacks Odds
| Underdog San Francisco Giants | Favorite Arizona Diamondbacks |
|---|---|
| Over | Under |
|---|---|
| Underdog Arizona Diamondbacks | Favorite San Francisco Giants |
|---|---|
Matchup Odds FAQs
The Arizona Diamondbacks are the -110 moneyline favorite at BetMGM and the San Francisco Giants are the -110 moneyline underdog at BetMGM.
The best over line is 9 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 9 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.
The San Francisco Giants are -1.5 +150 run line favorites at BetMGM, while the Arizona Diamondbacks are +1.5 -185 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Giants
Diamondbacks
9/17/25 3:40pm EDT | -110-110 |
- San Francisco Giants bettors risk $100 to win $90.91 at -110 odds. The implied probability for San Francisco Giants is 52.38%.
- Arizona Diamondbacks bettors risk $100 to win $90.91 at -110 odds. The implied probability for Arizona Diamondbacks is 52.38%.
San Francisco Giants at Arizona Diamondbacks Prop Bets
| BetMGM Bet |
|
|---|---|
Giants
Diamondbacks
First Team to Score
9/17/25 3:40pm EDT | -175+135Bet |
Giants
Diamondbacks
Tie
1st Inning Winner
9/17/25 3:40pm EDT | +260+310-125Bet |
Giants
Diamondbacks
Tie
First 3 Innings Winner
9/17/25 3:40pm EDT | +125+154+310Bet |
Giants
Diamondbacks
To Extra Innings
9/17/25 3:40pm EDT | Yes +800No -1400Bet |
| BetMGM | |
Giants
Diamondbacks
1st Team to Score Will Win
9/17/25 3:40pm EDT | Yes -250No +190Bet |
Diamondbacks
Total Runs
SFO at ARI 9/17/25 3:40pm EDT | 4.5 o +1004.5 u -130Bet |
Giants
Total Runs
SFO at ARI 9/17/25 3:40pm EDT | 4.5 o -1054.5 u -125Bet |
Brandon Pfaadt
Strikeouts Thrown
SFO at ARI 9/17/25 3:40pm EDT | 5.5 o +1255.5 u -160Bet |
| BetMGM | |
Justin Verlander
Strikeouts Thrown
SFO at ARI 9/17/25 3:40pm EDT | 4.5 o -1254.5 u -105Bet |
San Francisco Giants & Arizona Diamondbacks Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
San Francisco Giants World Series OddsNo World Series TM San Francisco Giants YR: futures available
Arizona Diamondbacks World Series OddsNo World Series TM Arizona Diamondbacks YR: futures available
San Francisco Giants & Arizona Diamondbacks Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - San Francisco Giants | 81 | 81 | 0.500 | +16.0 | 42-39 | 39-42 | 705 | 684 | +21 | W4 | 5-5 |
| e - Arizona Diamondbacks | 80 | 82 | 0.494 | +17.0 | 43-38 | 37-44 | 791 | 785 | +6 | L5 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco Giants vs Arizona Diamondbacks MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 17th, 2025 at 3:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the San Francisco Giants vs Arizona Diamondbacks Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs Arizona Diamondbacks Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 17, 2025 MLB Games
- Chicago Cubs vs Pittsburgh Pirates
- Cincinnati Reds vs St. Louis Cardinals
- Baltimore Orioles vs Chicago White Sox
- Atlanta Braves vs Washington Nationals
- Cleveland Guardians vs Detroit Tigers
- Oakland Athletics vs Boston Red Sox
- Toronto Blue Jays vs Tampa Bay Rays
- San Diego Padres vs New York Mets
- Seattle Mariners vs Kansas City Royals
- Los Angeles Angels vs Milwaukee Brewers
- New York Yankees vs Minnesota Twins
- Texas Rangers vs Houston Astros
- Miami Marlins vs Colorado Rockies
- Philadelphia Phillies vs Los Angeles Dodgers