San Francisco Giants vs Chicago Cubs Odds

The Giants will play the Cubs on Wednesday, May 7th, 2025. Your timezone's first pitch time is 2:20 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The San Francisco Giants have a 95.00 power ranking. The power ranking for the Chicago Cubs is 97.67.
  • Visiting San Francisco Giants - The San Francisco Giants have a 10-9 record as a visiting team, ranking them 3rd Overall for visiting team wins.
  • Home Chicago Cubs - The Chicago Cubs have a 10-7 record as a home team. They rank 6th for home team wins in the Overall standings.
  • Runs Scored - The San Francisco Giants currently stand 11th (166) Overall, with the Chicago Cubs ranking 1st (217) for runs scored.
  • Runs Allowed - The San Francisco Giants are 20th (138) Overall for runs allowed. The Chicago Cubs stand 15th (148) for runs allowed.
  • Team Streaks - The San Francisco Giants lost their last game. Meanwhile, the Chicago Cubs won their last game.
  • Team Records - The San Francisco Giants have a 22-14 Overall record (2.5 GB National West Division), with the Chicago Cubs possessing a 22-14 Overall standing (0.0 GB National Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Giants be facin' the Cubs in Chicago, arrr!

Both teams be boastin' a 22-14 record, tied like two barnacles on a ship...

Ye better bet on this game, me hearties, and review the odds below!

The Giants be needin' to improve their last 10 games record to plunder victory...

But beware, the Cubs be havin' the home field advantage and a winnin' streak!

Come Wednesday, May 7th, the battle on the diamond will be fierce, arrr!

Best Giants at Cubs Odds


Best Moneyline Betting Odds
Underdog

San Francisco Giants
Favorite

Chicago Cubs
The Chicago Cubs are the -160 moneyline favorite. Risk $160 to win $100 on the Chicago Cubs at BetMGM. The San Francisco Giants are the +140 underdog at BetRivers. Risk $100 to win $140 on the San Francisco Giants. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 7.5 runs. Risk $102 to win $100. BetRivers has the best under line of 7.5 runs. Risk $112 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

San Francisco Giants
Favorite

Chicago Cubs
The Chicago Cubs have a -1.5 +145 run line at BetMGM PA. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -165 run line at BetRivers PA. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs Chicago Cubs MLB game on Wednesday, May 7th, 2025?

The Chicago Cubs are the -160 moneyline favorite at BetMGM and the San Francisco Giants are the +140 moneyline underdog at BetRivers.

What is the over-under total line for the San Francisco Giants vs Chicago Cubs MLB game on Wednesday, May 7th, 2025?

The best over line is 7.5 -102 runs at BetMGM, which means you risk $102 to win $100 betting the over. The best under line is 7.5 -112 runs at BetRivers, and that means you risk $112 to win $100 betting the under.

What is the run line for the San Francisco Giants vs Chicago Cubs MLB game on Wednesday, May 7th, 2025?

The Chicago Cubs are -1.5 +145 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -165 run line underdogs at BetRivers.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
Cubs
5/07/25 2:20pm EDT
+135-160
Bet $100 at BetMGM Pennsylvania
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Possible Moneyline Outcomes
  • San Francisco Giants bettors risk $100 to win $135 at +135 odds. The implied probability for San Francisco Giants is 42.55%.
  • Chicago Cubs bettors risk $100 to win $62.5 at -160 odds. The implied probability for Chicago Cubs is 61.54%.

San Francisco Giants at Chicago Cubs Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Giants
Cubs
First Team to Score
5/07/25 2:20pm EDT
-120-105Bet
Giants
Cubs
Tie
1st Inning Winner
5/07/25 2:20pm EDT
+375+290-160Bet
Giants
Cubs
Tie
First 3 Innings Winner
5/07/25 2:20pm EDT
+195+115+240Bet
Giants
Cubs
To Extra Innings
5/07/25 2:20pm EDT
Yes +700No -1100Bet
BetMGM Sports Betting BetMGM
Giants
Cubs
1st Team to Score Will Win
5/07/25 2:20pm EDT
Yes -250No +190Bet
Cubs
Total Runs
SFO at CUB
5/07/25 2:20pm EDT
3.5 o -1453.5 u +110Bet
Giants
Total Runs
SFO at CUB
5/07/25 2:20pm EDT
3.5 o +1053.5 u -140Bet
Ben Brown
Strikeouts Thrown
SFO at CUB
5/07/25 2:20pm EDT
5.5 o -1205.5 u -110Bet
BetMGM Sports Betting BetMGM
Robbie Ray
Strikeouts Thrown
SFO at CUB
5/07/25 2:20pm EDT
5.5 o +1055.5 u -135Bet

San Francisco Giants & Chicago Cubs Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds
2025 San Francisco Giants World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Giants
+4000
Bet
+5000
Bet
Chicago Cubs World Series Odds
2025 Chicago Cubs World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Cubs
+1600
Bet
+1500
Bet

San Francisco Giants & Chicago Cubs Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Francisco Giants, Chicago Cubs
Team W L Pct GB Home Away RS RA Diff Strk L10
Chicago Cubs25190.568+4.012-1013-9244192+52L14-6
San Francisco Giants25190.568+4.013-712-12209172+37L14-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs Chicago Cubs MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 7th, 2025 at 2:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the San Francisco Giants vs Chicago Cubs Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs Chicago Cubs Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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