Louisville vs Cincinnati Basketball Odds

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The Cardinals will play the Bearcats on Friday, November 21st, 2025. Your timezone's tip off time is 6:30 pm EST. Check local listings or your nearest streaming app for coverage.

Review our College Basketball Betting guide to learn how to bet this game.


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Table of Contents

Key Matchup Stats

The Louisville and Cincinnati basketball teams will play on Friday, November 21st, 2025 as the 2025-26 college basketball season continues to roll along. Now that both teams have a few games under their belts, let’s size up this matchup by looking at some performance metrics and key stats.

  • SportsBetting3.com Power Rankings - Louisville currently has a 99.33 conference power ranking so far in the 2025-26 season. The SportsBetting3.com conference power ranking for Cincinnati is 99.33.
  • Away Louisville - Louisville heads into this game with a 0-0 record as an away team, ranking them 2nd in the ACC Conference for away team wins.
  • Home Cincinnati - Cincinnati will host Louisville sporting a 4-0 record as a home team. They currently rank 2nd in the Big 12 Conference for home team wins for the 2025-26 season.
  • Conference Win Percentage - Louisville currently ranks 1st (0.000) in the ACC Conference, with Cincinnati now standing 1st (0.000) for their conference win percentage in the 2025 Big 12 Conference for the 2025-26 college basketball season.
  • Overall Win Percentage - Louisville has a 1.000 overall win percentage. Their opponent, Cincinnati, has a 1.000 overall win percentage.
  • Team Records - Louisville has a 4-0 regular season overall record. Cincinnati has notched a 4-0 standing so far in the 2025-26 college basketball season.

Moneyline Mage

Spelling out the winners with humor since the middle ages.

Moneyline Mage
Moneyline Mage

The battle between Louisville and Cincinnati on November 21st is sure to be intense.

Both teams are undefeated with a 4-0 overall standing in the college basketball season.

With conference records determining tournament seeds, this game is crucial for both teams.

Louisville is 0-0 in the ACC Conference, while Cincinnati is 0-0 in the Big 12 Conference.

Both teams are on a 4-game winning streak, making this matchup even more exciting.

Our point spread, total, and moneyline tables show the best lines and odds for this matchup. Place a bet at BetMGM or BetRivers. Review each team’s futures odds and current standings below.

Best Cardinals at Bearcats Odds


Best Point Spread Betting Odds
Underdog

Cincinnati		Favorite

Louisville
+9.5 -115 BetMGM
Bet
-9.5 -105 BetMGM
Bet
Louisville has a -9.5 -105 point spread at BetMGM OH. They are the point spread favorite in this matchup. Cincinnati has a +9.5 -115 point spread at BetMGM OH. Cincinnati is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
163.5 o -105 BetMGM
Bet
163.5 u -115 BetMGM
Bet
BetMGM has the best over line of 163.5 points. Risk $105 to win $100. BetMGM has the best under line of 163.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

Matchup Odds FAQs

What is the point spread for the Louisville vs Cincinnati College Basketball game on Friday, November 21st, 2025?

Louisville is a -9.5 -105 point spread favorite at BetMGM, while Cincinnati is a +9.5 -115 point spread underdog at BetMGM.

What is the over-under total line for the Louisville vs Cincinnati College Basketball game on Friday, November 21st, 2025?

The best over line is 163.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 163.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

College Basketball Odds Example

College Basketball Odds and Outcomes Explained

Game		 BetMGM Sports Betting BetMGM
Bet
Louisville
Cincinnati
11/21/25 6:30pm EST
-9.5 -105+9.5 -115
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Underdog Cincinnati - Cincinnati bettors risk $100 to win $86.96 at -115 odds.

A +9.5 Cincinnati underdog bet wins if they lose by 9 or fewer, tie, or win outright. Your bet loses if they lose by 10 or more.

Favorite Louisville - Louisville bettors risk $100 to win $95.24 at -105 odds.

A -9.5 Louisville favorite bet wins if they win by 10 or more. Your bet loses if they win by 9 or fewer, tie, or lose outright.

Louisville at Cincinnati Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Basketball Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Louisville
Cincinnati
11/21/25 6:30pm EST
Pending BetMGM

Team Standings

2025-2026 College Basketball Regular Season Standings - Louisville, Cincinnati
Team W-L Win% Home Away Conf CGB Conf% Strk
ACC
#6 Louisville7-10.8756-00-10-0-0.000L1
Big 12
Cincinnati6-20.7506-10-00-0-0.000W1

Louisville & Cincinnati Futures Odds

Latest College Basketball Championship odds, if available, for each team. Review March Madness odds for other teams and learn how to bet on the college basketball tournament. Also be sure to read Ron Halfback's Final Four write-up.

Louisville Championship Odds
2025-26 Louisville NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending
Cincinnati Championship Odds
2025-26 Cincinnati NCAA Men's Basketball Tournament Odds

Team
OH,US ncaabb Evnum: 1 Odds Pending

Louisville & Cincinnati Team Pages

Review each team's futures odds, betting bonuses, current standings and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Louisville vs Cincinnati College Basketball Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Friday, November 21st, 2025 at 6:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Basketball page, look for the Louisville vs Cincinnati Game.

    Navigate to the sportsbook's College Basketball page. Next, look for live or upcoming matchups. Select the Louisville vs Cincinnati Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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