The Tigers will play the Cardinals on Friday, November 14th, 2025. The matchup takes place at L&N Federal Credit Union Stadium. Watch this exciting Week 12 matchup at 7:30 pm EST. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 12 action features a matchup between Clemson and Louisville, kicking off at L&N Federal Credit Union Stadium on Friday, November 14th, 2025. Have a look at the following season performance stats to better handicap this game.
- SportsBetting3.com Power Rankings - Clemson has a 94.67 conference power ranking for the 2025 season. The conference power ranking for Louisville is 96.67.
- Away Clemson - As Week 12 looms, Clemson currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
- Home Louisville - Louisville has a 4-2 record as a home team as they approach Week 12. They currently rank 3rd in the ACC Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
- Points Scored - For the 2025 season, Clemson ranks 9th (251) in the ACC Conference, with Louisville currently ranking 7th (296) for points scored in the ACC Conference.
- Points Against - Clemson stands 11th (202) in the ACC Conference for points scored by opponents in the 2025 college football season. Louisville sits at 13th (195) in the ACC Conference for points against them heading into Week 12 of the 2025 season.
- Team Records - Clemson has a 4-5 overall record for the 2025 regular season, with Louisville currently 7-2 for the 2025 college football regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for Clemson and Louisville to clash in a high-stakes Week 12 showdown!
The game will take place at L&N Federal Credit Union Stadium in Louisville.
Clemson is ranked at 94.67 by SportsBetting3.com, while Louisville is at 96.67.
Clemson has a 4-5 standing, while Louisville sits at 7-2.
Place a bet on this college football game at BetMGM or BetRivers. See this matchup's prop bets below and compare each sportsbook's point spread, total, and moneyline.
Best Tigers at Cardinals Odds
| Underdog Clemson | Favorite Louisville |
|---|---|
| Over | Under |
|---|---|
| Underdog Clemson | Favorite Louisville |
|---|---|
Matchup Odds FAQs
Louisville is a -1.5 -115 point spread favorite at BetMGM, while Clemson is a +1.5 -105 point spread underdog at BetMGM.
The best over line is 50.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 50.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.
Louisville is a -125 moneyline favorite at BetMGM and Clemson is a +105 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Clemson
Louisville
11/14/25 7:30pm EST | +1.5 -105-1.5 -115 |
Underdog Clemson - Clemson bettors risk $100 to win $95.24 at -105 odds.
A +1.5 Clemson underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.
Favorite Louisville - Louisville bettors risk $100 to win $86.96 at -115 odds.
A -1.5 Louisville favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.
Clemson at Louisville Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Clemson
Louisville
No Touchdown
To Score 1st Touchdown
11/14/25 7:30pm EST | +105-150+10000Bet |
Clemson
Louisville
Game to Overtime
11/14/25 7:30pm EST | Yes +1050No -10000Bet |
Clemson
Louisville
Both Teams Score 10+
11/14/25 7:30pm EST | Yes -1200No +650Bet |
Clemson
Louisville
Both Teams Score 20+
11/14/25 7:30pm EST | Yes -130No +100Bet |
| BetMGM | |
Clemson
Louisville
Both Teams Score 30+
11/14/25 7:30pm EST | Yes +525No -900Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 12 | Clemson vs Louisville Friday, November 14th, 2025 | CLEM 20, LOU 19 L&N Federal Credit Union Stadium | Clemson by 1 |
| 2024 Week 10 | Louisville vs Clemson Saturday, November 2nd, 2024 | LOU 33, CLEM 21 Memorial Stadium (Clemson, SC) | Louisville by 12 |
| 2022 Week 11 | Louisville vs Clemson Saturday, November 12th, 2022 | CLEM 31, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 15 |
| 2021 Week 10 | Clemson vs Louisville Saturday, November 6th, 2021 | CLEM 30, LOU 24 Cardinal Stadium | Clemson by 6 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| Clemson | 4-4 | 0.500 | 7 | 5 | 344 | 245 | 3-4 | 4-1 | W4 |
| Louisville | 4-4 | 0.500 | 8 | 4 | 362 | 253 | 5-3 | 3-1 | W1 |
Clemson & Louisville Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Clemson Championship OddsNo NCAA College Football Championship TM Clemson YR: futures available
Louisville Championship OddsNo NCAA College Football Championship TM Louisville YR: futures available
Clemson & Louisville Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | LSU vs Clemson | LSU 17, CLEM 10 Saturday, August 30th, 2025 |
| Week 2 | Troy vs Clemson | CLEM 27, TROY 16 Saturday, September 6th, 2025 |
| Week 3 | Clemson vs Georgia Tech | GT 24, CLEM 21 Saturday, September 13th, 2025 |
| Week 4 | Syracuse vs Clemson | SYR 34, CLEM 21 Saturday, September 20th, 2025 |
| Week 6 | Clemson vs North Carolina | CLEM 38, UNC 10 Saturday, October 4th, 2025 |
| Week 7 | Clemson vs Boston College | CLEM 41, BC 10 Saturday, October 11th, 2025 |
| Week 8 | SMU vs Clemson | SMU 35, CLEM 24 Saturday, October 18th, 2025 |
| Week 10 | Duke vs Clemson | DUKE 46, CLEM 45 Saturday, November 1st, 2025 |
| Week 11 | Florida State vs Clemson | CLEM 24, FSU 10 Saturday, November 8th, 2025 |
| Week 12 | Clemson vs Louisville | CLEM 20, LOU 19 Friday, November 14th, 2025 |
| Week 13 | Furman vs Clemson | CLEM 45, FUR 10 Saturday, November 22nd, 2025 |
| Week 14 | Clemson vs South Carolina | CLEM 28, SC 14 Saturday, November 29th, 2025 |
| Bowls | Penn State vs Clemson Bad Boy Mowers Pinstripe Bowl | Saturday, December 27th, 2025 12:00 pm EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Eastern Kentucky vs Louisville | LOU 51, EKU 17 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | Bowling Green vs Louisville | LOU 40, BGSU 17 Saturday, September 20th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Louisville vs Miami (FL) | LOU 24, MIA 21 Friday, October 17th, 2025 |
| Week 9 | Boston College vs Louisville | LOU 38, BC 24 Saturday, October 25th, 2025 |
| Week 10 | Louisville vs Virginia Tech | LOU 28, VT 16 Saturday, November 1st, 2025 |
| Week 11 | California vs Louisville | CAL 29, LOU 26 (OT) Saturday, November 8th, 2025 |
| Week 12 | Clemson vs Louisville | CLEM 20, LOU 19 Friday, November 14th, 2025 |
| Week 13 | Louisville vs SMU | SMU 38, LOU 6 Saturday, November 22nd, 2025 |
| Week 14 | Kentucky vs Louisville | LOU 41, UK 0 Saturday, November 29th, 2025 |
| Bowls | Toledo vs Louisville Bush's Boca Raton Bowl | Tuesday, December 23rd, 2025 2:00 pm EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Clemson vs Louisville College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Friday, November 14th, 2025 at 7:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Clemson vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Clemson vs Louisville Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.