The Colonels will play the Cardinals on Saturday, September 11th, 2021. The matchup takes place at Cardinal Stadium. Watch this exciting Week 2 matchup at 7:00 pm EDT. Check local listings for coverage on ACCNX, ESPN+.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Best Colonels at Cardinals Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
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Eastern Kentucky at Louisville Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
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	BetMGM Bet
Eastern Kentucky Louisville 9/11/21 7:00pm EDT	Pending BetMGM

Recent Meetings Since 2017

Recent Meetings Since 2017
Week	Game	Result	Margin
2021 Week 2	Eastern Kentucky vs Louisville Saturday, September 11th, 2021	LOU 30, EKU 3 Cardinal Stadium	Louisville by 27
2019 Week 2	Eastern Kentucky vs Louisville Saturday, September 7th, 2019	LOU 42, EKU 0 Cardinal Stadium	Louisville by 42

Team Standings

2021-2022 College Football Regular Season Standings - Eastern Kentucky, Louisville
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
ASUN-WAC
Eastern Kentucky	4-2	0.667	7	4	304	275	5-1	2-3	W1
ACC Atlantic
Louisville	4-4	0.500	6	7	411	355	4-3	2-2	L2

Eastern Kentucky & Louisville Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Eastern Kentucky Championship Odds

No NCAA College Football Championship TM Eastern Kentucky YR: futures available

Louisville Championship Odds

2025-26 Louisville NCAA College Football Championship Odds
Team
OH,US ncaafb Evnum: 1 Odds Pending

Eastern Kentucky & Louisville Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2021-22 Eastern Kentucky Games & Results
Week	Matchup	Date & Result
Week 2	Eastern Kentucky vs Louisville	LOU 30, EKU 3 Saturday, September 11th, 2021

2021-22 Louisville Games & Results
Week	Matchup	Date & Result
Week 1	Louisville vs Ole Miss	MISS 43, LOU 24 Monday, September 6th, 2021
Week 2	Eastern Kentucky vs Louisville	LOU 30, EKU 3 Saturday, September 11th, 2021
Week 3	UCF vs Louisville	LOU 42, UCF 35 Friday, September 17th, 2021
Week 4	Louisville vs Florida State	LOU 31, FSU 23 Saturday, September 25th, 2021
Week 5	Louisville vs Wake Forest	WAKE 37, LOU 34 Saturday, October 2nd, 2021
Week 6	Virginia vs Louisville	UVA 34, LOU 33 Saturday, October 9th, 2021
Week 8	Boston College vs Louisville	LOU 28, BC 14 Saturday, October 23rd, 2021
Week 9	Louisville vs NC State	NCST 28, LOU 13 Saturday, October 30th, 2021
Week 10	Clemson vs Louisville	CLEM 30, LOU 24 Saturday, November 6th, 2021
Week 11	Syracuse vs Louisville	LOU 41, SYR 3 Saturday, November 13th, 2021
Week 12	Louisville vs Duke	LOU 62, DUKE 22 Thursday, November 18th, 2021
Week 13	Kentucky vs Louisville	UK 52, LOU 21 Saturday, November 27th, 2021
Bowls	Air Force vs Louisville Servpro First Responder Bowl	AFA 31, LOU 28 Tuesday, December 28th, 2021

How to Bet on the Game

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How to Bet on the Eastern Kentucky vs Louisville College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 11th, 2021 at 7:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Eastern Kentucky vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Eastern Kentucky vs Louisville Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Eastern Kentucky vs Louisville Football Odds

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