The Cardinals will play the Tigers on Saturday, November 12th, 2022. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 11 matchup at 3:30 pm EST. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Schedules & Results
- Other Games Today
Best Cardinals at Tigers Odds
| Underdog Louisville | Favorite Clemson |
|---|---|
| Over | Under |
|---|---|
| Underdog Louisville | Favorite Clemson |
|---|---|
Matchup Odds FAQs
Clemson is a -7 -108 point spread favorite at BetRivers, while Louisville is a +7 -110 point spread underdog at BetMGM.
The best over line is 52 -109 points at BetRivers, which means you risk $109 to win $100 betting the over. The best under line is 52 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Clemson is a -275 moneyline favorite at BetMGM and Louisville is a +225 moneyline underdog at BetRivers.
College Football Odds Example
|
Game |
 BetRiversBet |
|---|---|
Louisville
Clemson
11/12/22 3:30pm EST |
Underdog Louisville - Louisville bettors risk $100 to win $88.5 at -113 odds.
A +7 Louisville underdog bet wins if they lose by 6 or fewer, tie, or win outright. The bet pushes if they lose by 7. Your bet loses if they lose by 8 or more.
Favorite Clemson - Clemson bettors risk $100 to win $92.59 at -108 odds.
A -7 Clemson favorite bet wins if they win by 8 or more. The bet pushes if they win by 7. Your bet loses if they win by 6 or fewer, tie, or lose outright.
Louisville at Clemson Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetRivers Bet |
|
|---|---|
Louisville
Clemson
First Team To Score
11/12/22 3:30pm EST | Bet |
Louisville
Clemson
Tie
First to 15 Points
11/12/22 3:30pm EST | Bet |
Louisville
Clemson
Tie
First to 20 Points
11/12/22 3:30pm EST | Bet |
Recent Meetings Since 2018
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 11 | Louisville vs Clemson Saturday, November 12th, 2022 | CLEM 31, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 15 |
| 2021 Week 10 | Clemson vs Louisville Saturday, November 6th, 2021 | CLEM 30, LOU 24 Cardinal Stadium | Clemson by 6 |
| 2019 Week 8 | Clemson vs Louisville Saturday, October 19th, 2019 | CLEM 45, LOU 10 Cardinal Stadium | Clemson by 35 |
| 2018 Week 10 | Louisville vs Clemson Saturday, November 3rd, 2018 | CLEM 77, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 61 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #13 Clemson | 8-0 | 1.000 | 11 | 3 | 465 | 292 | 6-1 | 4-1 | L1 |
| Louisville | 4-4 | 0.500 | 8 | 5 | 350 | 249 | 5-1 | 2-4 | W1 |
Louisville & Clemson Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.
Louisville Championship OddsNo NCAA College Football Championship TM Louisville YR: futures available
Clemson Championship OddsNo NCAA College Football Championship TM Clemson YR: futures available
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Louisville vs Syracuse | SYR 31, LOU 7 Saturday, September 3rd, 2022 |
| Week 2 | Louisville vs UCF | LOU 20, UCF 14 Friday, September 9th, 2022 |
| Week 3 | Florida State vs Louisville | FSU 35, LOU 31 Friday, September 16th, 2022 |
| Week 4 | South Florida vs Louisville | LOU 41, USF 3 Saturday, September 24th, 2022 |
| Week 5 | Louisville vs Boston College | BC 34, LOU 33 Saturday, October 1st, 2022 |
| Week 6 | Louisville vs Virginia | LOU 34, UVA 17 Saturday, October 8th, 2022 |
| Week 8 | Pittsburgh vs Louisville | LOU 24, PITT 10 Saturday, October 22nd, 2022 |
| Week 9 | Wake Forest vs Louisville | LOU 48, WAKE 21 Saturday, October 29th, 2022 |
| Week 10 | James Madison vs Louisville | LOU 34, JMU 10 Saturday, November 5th, 2022 |
| Week 11 | Louisville vs Clemson | CLEM 31, LOU 16 Saturday, November 12th, 2022 |
| Week 12 | NC State vs Louisville | LOU 25, NCST 10 Saturday, November 19th, 2022 |
| Week 13 | Louisville vs Kentucky | UK 26, LOU 13 Saturday, November 26th, 2022 |
| Bowls | Cincinnati vs Louisville Wasabi Fenway Bowl | LOU 24, CIN 7 Saturday, December 17th, 2022 |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Clemson vs Georgia Tech | CLEM 41, GT 10 Monday, September 5th, 2022 |
| Week 2 | Furman vs Clemson | CLEM 35, FUR 12 Saturday, September 10th, 2022 |
| Week 3 | Louisiana Tech vs Clemson | CLEM 48, LT 20 Saturday, September 17th, 2022 |
| Week 4 | Clemson vs Wake Forest | CLEM 51, WAKE 45 (2OT) Saturday, September 24th, 2022 |
| Week 5 | NC State vs Clemson | CLEM 30, NCST 20 Saturday, October 1st, 2022 |
| Week 6 | Clemson vs Boston College | CLEM 31, BC 3 Saturday, October 8th, 2022 |
| Week 7 | Clemson vs Florida State | CLEM 34, FSU 28 Saturday, October 15th, 2022 |
| Week 8 | Syracuse vs Clemson | CLEM 27, SYR 21 Saturday, October 22nd, 2022 |
| Week 10 | Clemson vs Notre Dame | ND 35, CLEM 14 Saturday, November 5th, 2022 |
| Week 11 | Louisville vs Clemson | CLEM 31, LOU 16 Saturday, November 12th, 2022 |
| Week 12 | Miami (FL) vs Clemson | CLEM 40, MIA 10 Saturday, November 19th, 2022 |
| Week 13 | South Carolina vs Clemson | SC 31, CLEM 30 Saturday, November 26th, 2022 |
| Week 14 | Clemson vs North Carolina | CLEM 39, UNC 10 Saturday, December 3rd, 2022 |
| Bowls | Tennessee vs Clemson Capital One Orange Bowl | TENN 31, CLEM 14 Friday, December 30th, 2022 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Louisville vs Clemson College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 12th, 2022 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Louisville vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs Clemson Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.