Louisville vs Clemson Football Odds

The Cardinals will play the Tigers on Saturday, November 12th, 2022. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 11 matchup at 3:30 pm EST. Check local listings for coverage on ESPN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets. Read the following to understand point spread betting.

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Point Spread
Underdog

Louisville
Favorite

Clemson
SportsBetting3.com has analyzed the latest lines. Review our "Point Spread" table above to smash the books. BetRivers VA has the best favorite Clemson point spread at -7 points. BetMGM has the best underdog Louisville point spread at +7 points. Review our point spread betting tutorial and video for more information.

Total
OverUnder
The over under line estimates the combined total of each team's final score. BetRivers has the best over line of 52 points laying $109 to win $100. BetMGM has the best under line of 52 points.

Moneyline
Underdog

Louisville
Favorite

Clemson
Here are money lines for the outright winner. Favorite Clemson has a minus value. Lay $275 to win $100 at BetMGM. Underdog Louisville has a positive value. Risk $100 at BetRivers to win $225.

SportsBetting3.com College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetRivers BetRivers
Bet
Louisville
Clemson
11/12/22 3:30pm EST

Underdog Louisville - Louisville bettors risk $100 to win $88.5 at -113 odds.

A +7 Louisville underdog bet wins if they lose by 6 or fewer, tie, or win outright. The bet pushes if they lose by 7. Your bet loses if they lose by 8 or more.

Favorite Clemson - Clemson bettors risk $100 to win $92.59 at -108 odds.

A -7 Clemson favorite bet wins if they win by 8 or more. The bet pushes if they win by 7. Your bet loses if they win by 6 or fewer, tie, or lose outright.

Louisville at Clemson Prop Bets

College Football Prop Bets
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BetRivers BetRivers
Bet
Louisville
Clemson
11/12/22 3:30pm EST - First Team To Score
Louisville
Clemson
Tie
11/12/22 3:30pm EST - First to 15 Points
Louisville
Clemson
Tie
11/12/22 3:30pm EST - First to 20 Points

Recent Meetings Since 2018

WeekGameResultMargin
2022
Week 11
Louisville vs Clemson
Saturday, November 12th, 2022
CLEM 31, LOU 16
Memorial Stadium (Clemson, SC)
Clemson by 15
2021
Week 10
Clemson vs Louisville
Saturday, November 6th, 2021
CLEM 30, LOU 24
Cardinal Stadium
Clemson by 6
2019
Week 8
Clemson vs Louisville
Saturday, October 19th, 2019
CLEM 45, LOU 10
Cardinal Stadium
Clemson by 35
2018
Week 10
Louisville vs Clemson
Saturday, November 3rd, 2018
CLEM 77, LOU 16
Memorial Stadium (Clemson, SC)
Clemson by 61

Team Season Win Totals

The following are each team's season win totals. Learn more about season win totals.

Louisville Season Win Total
2022 College Football Louisville Season Win Total
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BetRivers BetRivers
Bet
Louisville
2022 Season Win Total
Clemson Season Win Total
2022 College Football Clemson Season Win Total
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BetRivers BetRivers
Bet
Clemson
2022 Season Win Total

College Football Championship Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

Clemson Championship Odds

No NCAA College Football Championship TM Clemson YR: futures available

2022 Louisville Games & Results

WeekMatchupDate & Time
Week 1Louisville vs
Syracuse
SYR 31, LOU 7
Saturday, September 3rd, 2022
Week 2Louisville vs
UCF
LOU 20, UCF 14
Friday, September 9th, 2022
Week 3Florida State vs
Louisville
FSU 35, LOU 31
Friday, September 16th, 2022
Week 4South Florida vs
Louisville
LOU 41, USF 3
Saturday, September 24th, 2022
Week 5Louisville vs
Boston College
BC 34, LOU 33
Saturday, October 1st, 2022
Week 6Louisville vs
Virginia
LOU 34, UVA 17
Saturday, October 8th, 2022
Week 8Pittsburgh vs
Louisville
LOU 24, PITT 10
Saturday, October 22nd, 2022
Week 9Wake Forest vs
Louisville
LOU 48, WAKE 21
Saturday, October 29th, 2022
Week 10James Madison vs
Louisville
LOU 34, JMU 10
Saturday, November 5th, 2022
Week 11Louisville vs
Clemson
CLEM 31, LOU 16
Saturday, November 12th, 2022
Week 12NC State vs
Louisville
LOU 25, NCST 10
Saturday, November 19th, 2022
Week 13Louisville vs
Kentucky
UK 26, LOU 13
Saturday, November 26th, 2022

2022 Clemson Games & Results

WeekMatchupDate & Time
Week 1Clemson vs
Georgia Tech
CLEM 41, GT 10
Monday, September 5th, 2022
Week 2Furman vs
Clemson
CLEM 35, FUR 12
Saturday, September 10th, 2022
Week 3Louisiana Tech vs
Clemson
CLEM 48, LT 20
Saturday, September 17th, 2022
Week 4Clemson vs
Wake Forest
CLEM 51, WAKE 45 (2OT)
Saturday, September 24th, 2022
Week 5NC State vs
Clemson
CLEM 30, NCST 20
Saturday, October 1st, 2022
Week 6Clemson vs
Boston College
CLEM 31, BC 3
Saturday, October 8th, 2022
Week 7Clemson vs
Florida State
CLEM 34, FSU 28
Saturday, October 15th, 2022
Week 8Syracuse vs
Clemson
CLEM 27, SYR 21
Saturday, October 22nd, 2022
Week 10Clemson vs
Notre Dame
ND 35, CLEM 14
Saturday, November 5th, 2022
Week 11Louisville vs
Clemson
CLEM 31, LOU 16
Saturday, November 12th, 2022
Week 12Miami (FL) vs
Clemson
CLEM 40, MIA 10
Saturday, November 19th, 2022
Week 13South Carolina vs
Clemson
SC 31, CLEM 30
Saturday, November 26th, 2022
Week 14Clemson vs
North Carolina
Saturday, December 3rd, 2022
8:00 pm EST

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