Louisville Cardinals vs Duke Blue Devils Football Lines

Odds Preview 2230

The Cardinals will play the Blue Devils on Thursday, November 18th, 2021. The matchup takes place at Wallace Wade Stadium. Watch this exciting week 12 matchup at 7:30 pm on ESPN.

Best Underdog and Favorite Spread Bets

Underdog Duke	Favorite Louisville
+20.5 -110 Sb3gen2	-20 -110 Sb3gen3
+20 -107 Sb3gen1	-20 -113 Sb3gen1
+20 -110 Sb3gen3	-20.5 -110 Sb3gen2

SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Thursday. Sb3gen3 has the best favorite Louisville spread at -20 points. Sb3gen2 has the best underdog Duke spread at +20.5 points.

Review our point spread betting tutorial and video for more information.

Best Over and Under Total Lines

Over	Under
60o -110 Sb3gen1	60u -110 Sb3gen1
60o -110 Sb3gen2	60u -110 Sb3gen2
60o -110 Sb3gen3	60u -110 Sb3gen3

The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 60 points laying $110 to win $100. Sb3gen1 has the best under line of 60 u -110.

Best Money Line Bets

Underdog Duke	Favorite Louisville
+795 Sb3gen3	-1190 Sb3gen3
+790 Sb3gen1	-1300 Sb3gen1
+750 Sb3gen2	-1400 Sb3gen2

Here are money lines for the outright winner. Favorite Louisville has a minus value. Lay $1190 at Sb3gen3 to win $100. Underdog Duke has a positive value. Risk $100 at Sb3gen3 to win $795.

College Football Championship Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.

Louisville Championship Odds

Outcome	SB3Gen

Cached 2021-11-27 11:50:29
Duke Championship Odds

Outcome	SB3Gen

Cached 2021-11-27 11:50:29

2021 Louisville Games & Results

Week	Matchup	Date & Time
1	Louisville vs Ole Miss	MISS 43, LOU 24 09/06/2021
2	Eastern Kentucky vs Louisville	LOU 30, EKU 3 09/11/2021
3	UCF vs Louisville	LOU 42, UCF 35 09/17/2021
4	Louisville vs Florida State	LOU 31, FSU 23 09/25/2021
5	Louisville vs Wake Forest	WAKE 37, LOU 34 10/02/2021
6	Virginia vs Louisville	UVA 34, LOU 33 10/09/2021
8	Boston College vs Louisville	LOU 28, BC 14 10/23/2021
9	Louisville vs NC State	NCST 28, LOU 13 10/30/2021
10	Clemson vs Louisville	CLEM 30, LOU 24 11/06/2021
11	Syracuse vs Louisville	11/13/2021 12:00PM
12	Louisville vs Duke	LOU 62, DUKE 22 11/18/2021
13	Kentucky vs Louisville	11/27/2021 7:30PM

2021 Duke Games & Results

Week	Matchup	Date & Time
1	Duke vs Charlotte	CLT 31, DUKE 28 09/03/2021
2	North Carolina A&T vs Duke	DUKE 45, NCAT 17 09/10/2021
3	Northwestern vs Duke	DUKE 30, NU 23 09/18/2021
4	Kansas vs Duke	DUKE 52, KU 33 09/25/2021
5	Duke vs North Carolina	UNC 38, DUKE 7 10/02/2021
6	Georgia Tech vs Duke	GT 31, DUKE 27 10/09/2021
7	Duke vs Virginia	UVA 48, DUKE 0 10/16/2021
9	Duke vs Wake Forest	WAKE 45, DUKE 7 10/30/2021
10	Pittsburgh vs Duke	PITT 54, DUKE 29 11/06/2021
11	Duke vs Virginia Tech	11/13/2021 3:30PM
12	Louisville vs Duke	LOU 62, DUKE 22 11/18/2021
13	Miami (FL) vs Duke	11/27/2021 12:30PM

Other 2021 Week 12 Matchups

Matchup	Date & Time
Bowling Green vs Miami (OH)	M-OH 34, BGSU 7 11/16/2021
Western Michigan vs Eastern Michigan	EMU 22, WMU 21 11/16/2021
Toledo vs Ohio	TOL 35, OHIO 23 11/16/2021
Northern Illinois vs Buffalo	NIU 33, BUFF 27 (OT) 11/17/2021
Central Michigan vs Ball State	CMU 37, BALL 17 11/17/2021
Louisville vs Duke	LOU 62, DUKE 22 11/18/2021
Southern Miss vs Louisiana Tech	USM 35, LT 19 11/19/2021
Memphis vs Houston	HOU 31, MEM 13 11/19/2021
Arizona vs Washington State	WSU 44, ARIZ 18 11/19/2021
San Diego State vs UNLV	SDSU 28, UNLV 20 11/19/2021
Air Force vs Nevada	AFA 41, NEV 39 (3OT) 11/19/2021
Charleston Southern vs Georgia	UGA 56, CHSO 7 11/20/2021
Michigan State vs Ohio State	OSU 56, MSU 7 11/20/2021
Wake Forest vs Clemson	CLEM 48, WAKE 27 11/20/2021
Prairie View A&M vs Texas A&M	TA&M 52, PV 3 11/20/2021
Tennessee State vs Mississippi State	MSST 55, TNST 10 11/20/2021
New Mexico State vs Kentucky	UK 56, NMSU 16 11/20/2021
Florida State vs Boston College	FSU 26, BC 23 11/20/2021
Wofford vs North Carolina	UNC 34, WOF 14 11/20/2021
Texas vs West Virginia	WVU 31, TEX 23 11/20/2021
South Florida vs Tulane	TULN 45, USF 14 11/20/2021
Kent State vs Akron	KENT 38, AKR 0 11/20/2021
Florida Atlantic vs Western Kentucky	WKU 52, FAU 17 11/20/2021
Rutgers vs Penn State	PSU 28, RUTG 0 11/20/2021
UMass vs Army	ARMY 33, MASS 17 11/20/2021
Texas State vs Coastal Carolina	CCU 35, TXST 21 11/20/2021
Arkansas State vs Georgia State	GAST 28, ARST 20 11/20/2021
Georgia Tech vs Notre Dame	ND 55, GT 0 11/20/2021
Michigan vs Maryland	MICH 59, MD 18 11/20/2021
Nebraska vs Wisconsin	WISC 35, NEB 28 11/20/2021
Appalachian State vs Troy	APP 45, TROY 7 11/20/2021
Marshall vs Charlotte	MRSH 49, CLT 28 11/20/2021
Old Dominion vs Middle Tennessee	ODU 24, MTSU 17 11/20/2021
UAB vs UTSA	UTSA 34, UAB 31 11/20/2021
East Carolina vs Navy	ECU 38, NAVY 35 11/20/2021