The Cardinals will play the Blue Devils on Thursday, November 18th, 2021. The matchup takes place at Wallace Wade Stadium. Watch this exciting Week 12 matchup at 7:30 pm EST. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets. Read the following to understand point spread betting.
| STATE |
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|---|---|
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| Underdog | Favorite |
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| Over | Under |
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| Underdog | Favorite |
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College Football Odds Example
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Game |
Bet |
|---|---|
2:44pm EDT | TBD VA |
VA Odds Pending
No VA Point Spread lines available for this game.
No VA Point Spread lines available for this game.
Louisville at Duke Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
 BetRiversBet |
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|---|---|
Louisville
Duke
11/18/21 7:30pm EST | Pending BetRivers |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2021 Week 12 | Louisville vs Duke Thursday, November 18th, 2021 | LOU 62, DUKE 22 Wallace Wade Stadium | Louisville by 40 |
Team Season Win Totals
The following are each team's season win totals. Learn more about season win totals.
Louisville Season Win Total| BetRivers Bet |
|
|---|---|
Louisville
2023 Season Win Total |
| BetRivers Bet |
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|---|---|
Duke
2023 Season Win Total |
College Football Championship Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.
Louisville Championship Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| Louisville |
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Team | BetRivers |
BetMGM |
|---|---|---|
| Duke |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| ACC Atlantic | |||||||||
| Louisville | 4-4 | 0.500 | 6 | 7 | 411 | 355 | 4-3 | 2-2 | L2 |
| ACC Coastal | |||||||||
| Duke | 0-8 | 0.000 | 3 | 9 | 274 | 477 | 3-4 | 0-5 | L8 |
2021-22 Louisville Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Week 1 | Louisville vs Ole Miss | MISS 43, LOU 24 Monday, September 6th, 2021 |
| Week 2 | Eastern Kentucky vs Louisville | LOU 30, EKU 3 Saturday, September 11th, 2021 |
| Week 3 | UCF vs Louisville | LOU 42, UCF 35 Friday, September 17th, 2021 |
| Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
| Week 5 | Louisville vs Wake Forest | WAKE 37, LOU 34 Saturday, October 2nd, 2021 |
| Week 6 | Virginia vs Louisville | UVA 34, LOU 33 Saturday, October 9th, 2021 |
| Week 8 | Boston College vs Louisville | LOU 28, BC 14 Saturday, October 23rd, 2021 |
| Week 9 | Louisville vs NC State | NCST 28, LOU 13 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | Syracuse vs Louisville | LOU 41, SYR 3 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Kentucky vs Louisville | UK 52, LOU 21 Saturday, November 27th, 2021 |
| Bowls | Air Force vs Louisville Servpro First Responder Bowl | AFA 31, LOU 28 Tuesday, December 28th, 2021 |
2021-22 Duke Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Week 1 | Duke vs Charlotte | CLT 31, DUKE 28 Friday, September 3rd, 2021 |
| Week 2 | North Carolina A&T vs Duke | DUKE 45, NCAT 17 Friday, September 10th, 2021 |
| Week 3 | Northwestern vs Duke | DUKE 30, NU 23 Saturday, September 18th, 2021 |
| Week 4 | Kansas vs Duke | DUKE 52, KU 33 Saturday, September 25th, 2021 |
| Week 5 | Duke vs North Carolina | UNC 38, DUKE 7 Saturday, October 2nd, 2021 |
| Week 6 | Georgia Tech vs Duke | GT 31, DUKE 27 Saturday, October 9th, 2021 |
| Week 7 | Duke vs Virginia | UVA 48, DUKE 0 Saturday, October 16th, 2021 |
| Week 9 | Duke vs Wake Forest | WAKE 45, DUKE 7 Saturday, October 30th, 2021 |
| Week 10 | Pittsburgh vs Duke | PITT 54, DUKE 29 Saturday, November 6th, 2021 |
| Week 11 | Duke vs Virginia Tech | VT 48, DUKE 17 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Miami (FL) vs Duke | MIA 47, DUKE 10 Saturday, November 27th, 2021 |
Other November 18, 2021 NCAAFB Games
| Matchup |
|---|
| Nicholls vs Southeastern Louisiana |