The Cardinals will play the Seminoles on Saturday, September 25th, 2021. The matchup takes place at Doak Campbell Stadium. Watch this exciting Week 4 matchup at 3:30 pm EDT. Check local listings for coverage on ESPN2.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets. Read the following to understand point spread betting.
| STATE |
Bonus |
|---|---|
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| Underdog | Favorite |
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| Over | Under |
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| Underdog | Favorite |
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College Football Odds Example
|
Game |
Bet |
|---|---|
3:28pm EDT | TBD VA |
VA Odds Pending
No VA Point Spread lines available for this game.
No VA Point Spread lines available for this game.
Louisville at Florida State Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
 BetRiversBet |
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|---|---|
Louisville
Florida State
9/25/21 3:30pm EDT | Pending BetRivers |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 3 | Florida State vs Louisville Friday, September 16th, 2022 | FSU 35, LOU 31 Cardinal Stadium | Florida State by 4 |
| 2021 Week 4 | Louisville vs Florida State Saturday, September 25th, 2021 | LOU 31, FSU 23 Doak Campbell Stadium | Louisville by 8 |
| 2020 Week 8 | Florida State vs Louisville Saturday, October 24th, 2020 | LOU 48, FSU 16 Cardinal Stadium | Louisville by 32 |
| 2019 Week 4 | Louisville vs Florida State Saturday, September 21st, 2019 | FSU 35, LOU 24 Doak Campbell Stadium | Florida State by 11 |
| 2018 Week 5 | Florida State vs Louisville Saturday, September 29th, 2018 | FSU 28, LOU 24 Cardinal Stadium | Florida State by 4 |
| 2017 Week 8 | Louisville vs Florida State Saturday, October 21st, 2017 | LOU 31, FSU 28 Doak Campbell Stadium | Louisville by 3 |
Team Season Win Totals
The following are each team's season win totals. Learn more about season win totals.
Louisville Season Win Total| BetRivers Bet |
|
|---|---|
Louisville
2023 Season Win Total |
| BetRivers Bet |
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|---|---|
Florida State
2023 Season Win Total |
College Football Championship Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.
Louisville Championship Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| Louisville |
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Team | BetRivers |
BetMGM |
|---|---|---|
| Florida State |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| Florida State | 4-4 | 0.500 | 5 | 7 | 331 | 318 | 3-4 | 2-3 | L1 |
| Louisville | 4-4 | 0.500 | 6 | 7 | 411 | 355 | 4-3 | 2-2 | L2 |
2021-22 Louisville Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Week 1 | Louisville vs Ole Miss | MISS 43, LOU 24 Monday, September 6th, 2021 |
| Week 2 | Eastern Kentucky vs Louisville | LOU 30, EKU 3 Saturday, September 11th, 2021 |
| Week 3 | UCF vs Louisville | LOU 42, UCF 35 Friday, September 17th, 2021 |
| Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
| Week 5 | Louisville vs Wake Forest | WAKE 37, LOU 34 Saturday, October 2nd, 2021 |
| Week 6 | Virginia vs Louisville | UVA 34, LOU 33 Saturday, October 9th, 2021 |
| Week 8 | Boston College vs Louisville | LOU 28, BC 14 Saturday, October 23rd, 2021 |
| Week 9 | Louisville vs NC State | NCST 28, LOU 13 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | Syracuse vs Louisville | LOU 41, SYR 3 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Kentucky vs Louisville | UK 52, LOU 21 Saturday, November 27th, 2021 |
| Bowls | Air Force vs Louisville Servpro First Responder Bowl | AFA 31, LOU 28 Tuesday, December 28th, 2021 |
2021-22 Florida State Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Week 1 | Notre Dame vs Florida State | ND 41, FSU 38 (OT) Sunday, September 5th, 2021 |
| Week 2 | Jacksonville State vs Florida State | JVST 20, FSU 17 Saturday, September 11th, 2021 |
| Week 3 | Florida State vs Wake Forest | WAKE 35, FSU 14 Saturday, September 18th, 2021 |
| Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
| Week 5 | Syracuse vs Florida State | FSU 33, SYR 30 Saturday, October 2nd, 2021 |
| Week 6 | Florida State vs North Carolina | FSU 35, UNC 25 Saturday, October 9th, 2021 |
| Week 8 | UMass vs Florida State | FSU 59, MASS 3 Saturday, October 23rd, 2021 |
| Week 9 | Florida State vs Clemson | CLEM 30, FSU 20 Saturday, October 30th, 2021 |
| Week 10 | NC State vs Florida State | NCST 28, FSU 14 Saturday, November 6th, 2021 |
| Week 11 | Miami (FL) vs Florida State | FSU 31, MIA 28 Saturday, November 13th, 2021 |
| Week 12 | Florida State vs Boston College | FSU 26, BC 23 Saturday, November 20th, 2021 |
| Week 13 | Florida State vs Florida | FLA 24, FSU 21 Saturday, November 27th, 2021 |