Louisville vs Syracuse Football Odds

The Cardinals will play the Orange on Saturday, September 3rd, 2022. The matchup takes place at JMA Wireless Dome. Watch this exciting Week 1 matchup at 8:00 pm EDT. Check local listings for coverage on ACCN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets. Read the following to understand point spread betting.

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Point Spread
Underdog

Syracuse
Favorite

Louisville
+6 -121 BetRivers-6 +100 BetRivers
SportsBetting3.com has analyzed the latest lines. Review our "Point Spread" table above to smash the books. BetRivers VA has the best favorite Louisville point spread at -6 points. BetRivers has the best underdog Syracuse point spread at +6 points. Review our point spread betting tutorial and video for more information.

Total
OverUnder
55.5o -109 BetRivers55.5u -112 BetRivers
The over under line estimates the combined total of each team's final score. BetRivers has the best over line of 55.5 points laying $109 to win $100. BetRivers has the best under line of 55.5 points.

Moneyline
Underdog

Syracuse
Favorite

Louisville
+170 BetRivers-215 BetRivers
Here are money lines for the outright winner. Favorite Louisville has a minus value. Lay $215 to win $100 at BetRivers. Underdog Syracuse has a positive value. Risk $100 at BetRivers to win $170.

SportsBetting3.com College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetRivers BetRivers
Bet
Louisville
Syracuse
9/03/22 8:00pm EDT

Underdog Syracuse - Syracuse bettors risk $100 to win $82.64 at -121 odds.

A +6 Syracuse underdog bet wins if they lose by 5 or fewer, tie, or win outright. The bet pushes if they lose by 6. Your bet loses if they lose by 7 or more.

Favorite Louisville - Louisville bettors risk $100 to win $100 at +100 odds.

A -6 Louisville favorite bet wins if they win by 7 or more. The bet pushes if they win by 6. Your bet loses if they win by 5 or fewer, tie, or lose outright.

Louisville at Syracuse Prop Bets

College Football Prop Bets
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Louisville
Syracuse
9/03/22 8:00pm EDT - First Team To Score
Louisville
Syracuse
Tie
9/03/22 8:00pm EDT - First to 15 Points
Louisville
Syracuse
Tie
9/03/22 8:00pm EDT - First to 20 Points

Recent Meetings Since 2018

WeekGameResultMargin
2022
Week 1
Louisville vs Syracuse
Saturday, September 3rd, 2022
SYR 31, LOU 7
JMA Wireless Dome
Syracuse by 24
2021
Week 11
Syracuse vs Louisville
Saturday, November 13th, 2021
LOU 41, SYR 3
Cardinal Stadium
Louisville by 38
2019
Week 13
Syracuse vs Louisville
Saturday, November 23rd, 2019
LOU 56, SYR 34
Cardinal Stadium
Louisville by 22
2018
Week 11
Louisville vs Syracuse
Friday, November 9th, 2018
SYR 54, LOU 23
JMA Wireless Dome
Syracuse by 31

Team Season Win Totals

The following are each team's season win totals. Learn more about season win totals.

Louisville Season Win Total
2022 College Football Louisville Season Win Total
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Louisville
2022 Season Win Total
Syracuse Season Win Total
2022 College Football Syracuse Season Win Total
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Syracuse
2022 Season Win Total

College Football Championship Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets here.

Louisville Championship Odds
2023 Louisville NCAA College Football Championship Odds

Team
BetRivers BetRivers
Louisville
Syracuse Championship Odds
2023 Syracuse NCAA College Football Championship Odds

Team
BetRivers BetRivers
Syracuse

2022 Louisville Games & Results

WeekMatchupDate & Time
Week 1Louisville vs
Syracuse
SYR 31, LOU 7
Saturday, September 3rd, 2022
Week 2Louisville vs
UCF
LOU 20, UCF 14
Friday, September 9th, 2022
Week 3Florida State vs
Louisville
FSU 35, LOU 31
Friday, September 16th, 2022
Week 4South Florida vs
Louisville
LOU 41, USF 3
Saturday, September 24th, 2022
Week 5Louisville vs
Boston College
Saturday, October 1st, 2022
12:00 pm EDT
Week 6Louisville vs
Virginia
Saturday, October 8th, 2022
12:00 pm EDT
Week 8Pittsburgh vs
Louisville
Saturday, October 22nd, 2022
12:00 am EDT
Week 9Wake Forest vs
Louisville
Saturday, October 29th, 2022
12:00 am EDT
Week 10James Madison vs
Louisville
Saturday, November 5th, 2022
12:00 am EDT
Week 11Louisville vs
Clemson
Saturday, November 12th, 2022
12:00 am EST
Week 12NC State vs
Louisville
Saturday, November 19th, 2022
12:00 am EST
Week 13Louisville vs
Kentucky
Saturday, November 26th, 2022
12:00 am EST

2022 Syracuse Games & Results

WeekMatchupDate & Time
Week 1Louisville vs
Syracuse
SYR 31, LOU 7
Saturday, September 3rd, 2022
Week 2Syracuse vs
UConn
SYR 48, CONN 14
Saturday, September 10th, 2022
Week 3Purdue vs
Syracuse
SYR 32, PUR 29
Saturday, September 17th, 2022
Week 4Virginia vs
Syracuse
SYR 22, UVA 20
Friday, September 23rd, 2022
Week 5Wagner vs
Syracuse
Saturday, October 1st, 2022
5:00 pm EDT
Week 7NC State vs
Syracuse
Saturday, October 15th, 2022
12:00 am EDT
Week 8Syracuse vs
Clemson
Saturday, October 22nd, 2022
12:00 am EDT
Week 9Notre Dame vs
Syracuse
Saturday, October 29th, 2022
12:00 am EDT
Week 10Syracuse vs
Pittsburgh
Saturday, November 5th, 2022
12:00 am EDT
Week 11Florida State vs
Syracuse
Saturday, November 12th, 2022
12:00 am EST
Week 12Syracuse vs
Wake Forest
Saturday, November 19th, 2022
12:00 am EST
Week 13Syracuse vs
Boston College
Saturday, November 26th, 2022
12:00 am EST

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