Northwestern vs USC Football Odds

The Wildcats will play the Trojans on Friday, November 7th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 11 matchup at 9:00 pm EST. Check local listings for coverage on FOX.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 11 action features a matchup between Northwestern and USC, kicking off at Los Angeles Memorial Coliseum on Friday, November 7th, 2025. Have a look at the following season performance stats to better handicap this game.

  • SportsBetting3.com Power Rankings - Northwestern has a 93.00 conference power ranking for the 2025 season. The conference power ranking for USC is 96.00.
  • Away Northwestern - As Week 11 looms, Northwestern currently has a 1-2 record as an away team for the 2025 regular season. This ranks them 3rd in the Big Ten Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
  • Home USC - USC has a 4-0 record as a home team as they approach Week 11. They currently rank 3rd in the Big Ten Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
  • Points Scored - For the 2025 season, Northwestern ranks 16th (180) in the Big Ten Conference, with USC currently ranking 3rd (318) for points scored in the Big Ten Conference.
  • Points Against - Northwestern stands 14th (134) in the Big Ten Conference for points scored by opponents in the 2025 college football season. USC sits at 8th (179) in the Big Ten Conference for points against them heading into Week 11 of the 2025 season.
  • Team Records - Northwestern has a 5-3 overall record for the 2025 regular season, with USC currently 6-2 for the 2025 college football regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Get ready for a wild showdown between Northwestern and USC on November 7th!

The game will be held at Los Angeles Memorial Coliseum in the heart of Hollywood.

Northwestern sits at 93.00 in the Power Rankings, while USC is at 96.00.

Northwestern has a 5-3 record, while USC boasts a 6-2 standing.

Place a bet on this college football game at BetMGM or BetRivers, see this matchup's prop bets below, and compare each sportsbook's point spread, total, and moneyline.

Best Wildcats at Trojans Odds


Best Point Spread Betting Odds
Underdog

Northwestern
Favorite

USC
USC has a -14.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. Northwestern has a +14.5 -105 point spread at BetMGM OH. Northwestern is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 51.5 points. Risk $115 to win $100. BetMGM has the best under line of 51.5 points. Risk $105 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

Matchup Odds FAQs

What is the point spread for the Northwestern vs USC College Football game on Friday, November 7th, 2025?

USC is a -14.5 -115 point spread favorite at BetMGM, while Northwestern is a +14.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the Northwestern vs USC College Football game on Friday, November 7th, 2025?

The best over line is 51.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 51.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.

College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Northwestern
USC
11/07/25 9:00pm EST
+14.5 -105-14.5 -115
Bet $100 at BetMGM Ohio
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Gambling Problem? Call 1-800-589-9966

Underdog Northwestern - Northwestern bettors risk $100 to win $95.24 at -105 odds.

A +14.5 Northwestern underdog bet wins if they lose by 14 or fewer, tie, or win outright. Your bet loses if they lose by 15 or more.

Favorite USC - USC bettors risk $100 to win $86.96 at -115 odds.

A -14.5 USC favorite bet wins if they win by 15 or more. Your bet loses if they win by 14 or fewer, tie, or lose outright.

Northwestern at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Northwestern
USC
11/07/25 9:00pm EST
Pending BetMGM

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin

Team Standings

2025-2026 College Football Regular Season Standings - Northwestern, USC
Team Conf Conf% W L PF PA Home Away Strk
#23 USC4-10.800623181794-02-2W1
Northwestern3-20.600531801344-11-2L1

Northwestern & USC Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Northwestern Championship Odds

No NCAA College Football Championship TM Northwestern YR: futures available

USC Championship Odds
2025-26 USC NCAA College Football Championship Odds

Team
BetMGM Sports Betting BetMGM
USC
+8000
Bet

Northwestern & USC Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Northwestern Games & Results
WeekMatchupDate & Result
Week 1Northwestern vs
Tulane
TULN 23, NU 3
Saturday, August 30th, 2025
Week 2Western Illinois vs
Northwestern
NU 42, WIU 7
Friday, September 5th, 2025
Week 3Oregon vs
Northwestern
ORE 34, NU 14
Saturday, September 13th, 2025
Week 5UCLA vs
Northwestern
NU 17, UCLA 14
Saturday, September 27th, 2025
Week 6Louisiana-Monroe vs
Northwestern
NU 42, ULM 7
Saturday, October 4th, 2025
Week 7Northwestern vs
Penn State
NU 22, PSU 21
Saturday, October 11th, 2025
Week 8Purdue vs
Northwestern
NU 19, PUR 0
Saturday, October 18th, 2025
Week 9Northwestern vs
Nebraska
Saturday, October 25th, 2025
12:00 pm EDT
Week 11Northwestern vs
USC
Friday, November 7th, 2025
9:00 pm EST
Week 12Michigan vs
Northwestern
Saturday, November 15th, 2025
12:00 am EST
Week 13Minnesota vs
Northwestern
Saturday, November 22nd, 2025
12:00 am EST
Week 14Northwestern vs
Illinois
Saturday, November 29th, 2025
12:00 am EST


2025-26 USC Games & Results
WeekMatchupDate & Result
Week 1Missouri State vs
USC
USC 73, MOST 13
Saturday, August 30th, 2025
Week 2Georgia Southern vs
USC
USC 59, GASO 20
Saturday, September 6th, 2025
Week 3USC vs
Purdue
USC 33, PUR 17
Saturday, September 13th, 2025
Week 4Michigan State vs
USC
USC 45, MSU 31
Saturday, September 20th, 2025
Week 5USC vs
Illinois
ILL 34, USC 32
Saturday, September 27th, 2025
Week 7Michigan vs
USC
USC 31, MICH 13
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame
ND 34, USC 24
Saturday, October 18th, 2025
Week 10USC vs
Nebraska
Saturday, November 1st, 2025
7:30 pm EDT
Week 11Northwestern vs
USC
Friday, November 7th, 2025
9:00 pm EST
Week 12Iowa vs
USC
Saturday, November 15th, 2025
12:00 am EST
Week 13USC vs
Oregon
Saturday, November 22nd, 2025
12:00 am EST
Week 14UCLA vs
USC
Saturday, November 29th, 2025
12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Northwestern vs USC College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Friday, November 7th, 2025 at 9:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Northwestern vs USC Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Northwestern vs USC Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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