The Bills will play the Browns on Sunday, December 21st, 2025. The matchup takes place at Huntington Bank Field. Watch this exciting Week 16 matchup at 1:00 pm EST. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 16, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the Buffalo Bills and Cleveland Browns. They'll play on Sunday, December 21st, 2025 at Huntington Bank Field, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 16 of the 2025-26 NFL regular season, the Buffalo Bills have a 96.33 power ranking based on our formula. Their opponent, the Cleveland Browns, currently possess a 84.33 power ranking.
- Away Buffalo Bills - With the season coming to a close, the Buffalo Bills have a 4-3-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home Cleveland Browns - The Cleveland Browns come to this Week 16 game with a 2-5-0 record as a home team. They rank 6th in the league for home team wins as the 2025-26 regular season wraps up.
- Points Scored - The Buffalo Bills currently rank 3rd (411) headed into Week 16, with the Cleveland Browns ranked 28th (226) for points scored to date.
- Points Against - As the regular season winds down, the Buffalo Bills rank 14th (324) for points score against them. Note that the Cleveland Browns now rank 13th (332) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 16, the Buffalo Bills have a 10-4-0 record, with the Cleveland Browns at 3-11-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast, ye scallywags! The Bills be comin' to Cleveland for a crucial showdown!
The NFL season be windin' down, and the outcome of this match be pivotal.
Buffalo be sittin' pretty at 10-4-0, while Cleveland be strugglin' at 3-11-0. Place a bet at BetRivers or BetMGM and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks to help ye out. Arrr!
Best Bills at Browns Odds
| Underdog Cleveland Browns | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Cleveland Browns | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -10 -110 point spread favorites at BetMGM, while the Cleveland Browns are +10 -110 point spread underdogs at BetMGM.
The best over line is 42 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 42 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -600 moneyline favorite at BetMGM and the Cleveland Browns are the +425 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Bills
Browns
12/21/25 1:00pm EST | -10 -110+10 -110 |
Underdog Cleveland Browns - Cleveland Browns bettors risk $100 to win $90.91 at -110 odds.
A +10 Cleveland Browns underdog bet wins if they lose by 9 or fewer, tie, or win outright. The bet pushes if they lose by 10. Your bet loses if they lose by 11 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.
A -10 Buffalo Bills favorite bet wins if they win by 11 or more. The bet pushes if they win by 10. Your bet loses if they win by 9 or fewer, tie, or lose outright.
Buffalo Bills at Cleveland Browns Prop Bets
| BetMGM Bet |
|
|---|---|
Bills
Browns
First Team To Score
12/21/25 1:00pm EST | -185+140Bet |
Bills
Browns
No Touchdown
To Score 1st Touchdown
12/21/25 1:00pm EST | -250+180+10000Bet |
Bills
Browns
Game to Overtime
12/21/25 1:00pm EST | Yes +900No -5000Bet |
Bills
Browns
Safety to be Scored
12/21/25 1:00pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Josh Allen
Interceptions Thrown
BUF at CLE 12/21/25 1:00pm EST | 0.5 o +1150.5 u -150Bet |
Shedeur Sanders
Interceptions Thrown
BUF at CLE 12/21/25 1:00pm EST | 0.5 o -1900.5 u +140Bet |
Josh Allen
Longest Passing Completion
BUF at CLE 12/21/25 1:00pm EST | 34.5 o -11534.5 u -118Bet |
Shedeur Sanders
Longest Passing Completion
BUF at CLE 12/21/25 1:00pm EST | 31.5 o -11831.5 u -110Bet |
| BetMGM | |
Andre Szmyt
Total Kicking Points
BUF at CLE 12/21/25 1:00pm EST | 4.5 o -1404.5 u +105Bet |
Josh Allen
Total Pass Completions
BUF at CLE 12/21/25 1:00pm EST | 18.5 o -14018.5 u +105Bet |
Shedeur Sanders
Total Pass Completions
BUF at CLE 12/21/25 1:00pm EST | 15.5 o -13515.5 u +100Bet |
Josh Allen
Total Passing Yards
BUF at CLE 12/21/25 1:00pm EST | 215.5 o -115215.5 u -115Bet |
| BetMGM | |
Shedeur Sanders
Total Passing Yards
BUF at CLE 12/21/25 1:00pm EST | 175.5 o -115175.5 u -115Bet |
Josh Allen
Total Touchdown Passes
BUF at CLE 12/21/25 1:00pm EST | 1.5 o +1151.5 u -155Bet |
Shedeur Sanders
Total Touchdown Passes
BUF at CLE 12/21/25 1:00pm EST | 0.5 o -1750.5 u +130Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 11 | Browns vs Bills Sunday, November 20th, 2022 | BUF 31, CLE 23 Ford Field | Bills by 8 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buffalo Bills | 10 | 4 | 0 | 0.714 | 411 | 324 | 6-1-0 | 4-3-0 | 3-2-0 | 0.600 | 7-3-0 | 0.700 | 3W | 4-1-0 |
| Cleveland Browns | 3 | 11 | 0 | 0.214 | 226 | 332 | 2-5-0 | 1-6-0 | 0-4-0 | 0.000 | 2-7-0 | 0.222 | 3L | 1-4-0 |
Buffalo Bills & Cleveland Browns Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetMGM |
|---|---|
| Bills | +800 Bet |
No Super Bowl TM Cleveland Browns YR: futures available
Buffalo Bills & Cleveland Browns Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs Cleveland Browns NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 21st, 2025 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Cleveland Browns Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Cleveland Browns Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 21, 2025 NFL Games
- Tampa Bay Buccaneers vs Carolina Panthers - 12/21/25 1:00pm EST
- Kansas City Chiefs vs Tennessee Titans - 12/21/25 1:00pm EST
- Minnesota Vikings vs New York Giants - 12/21/25 1:00pm EST
- New York Jets vs New Orleans Saints - 12/21/25 1:00pm EST
- Cincinnati Bengals vs Miami Dolphins - 12/21/25 1:00pm EST
- Los Angeles Chargers vs Dallas Cowboys - 12/21/25 1:00pm EST
- Jacksonville Jaguars vs Denver Broncos - 12/21/25 4:05pm EST
- Atlanta Falcons vs Arizona Cardinals - 12/21/25 4:05pm EST
- Pittsburgh Steelers vs Detroit Lions - 12/21/25 4:25pm EST
- Las Vegas Raiders vs Houston Texans - 12/21/25 4:25pm EST
- New England Patriots vs Baltimore Ravens - 12/21/25 8:20pm EST