The Bills will play the Saints on Thursday, November 25th, 2021. The matchup takes place at Caesars Superdome. Watch this exciting Week 12 matchup at 8:20 pm EST. Check local listings for coverage on NBC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Bills at Saints Odds
| Underdog | Favorite |
|---|
| Over | Under |
|---|
| Underdog | Favorite |
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NFL Odds Example
|
Game |
Bet |
|---|---|
1:07am EDT | TBD OH,US |
No OH,US Point Spread lines available for this game.
Buffalo Bills at New Orleans Saints Prop Bets
 BetMGMBet |
|
|---|---|
Bills
Saints
11/25/21 8:20pm EST | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2021 Week 12 | Bills vs Saints Thursday, November 25th, 2021 | BUF 31, NO 6 Caesars Superdome | Bills by 25 |
| 2017 Week 10 | Saints vs Bills Sunday, November 12th, 2017 | NO 47, BUF 10 Highmark Stadium | Saints by 37 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 11 | 6 | 0 | 0.647 | 483 | 289 | 6-3-0 | 5-3-0 | 5-1-0 | 0.833 | 7-5-0 | 0.583 | 4W | 4-1-0 |
| New Orleans Saints | 9 | 8 | 0 | 0.529 | 364 | 335 | 3-5-0 | 6-3-0 | 4-2-0 | 0.667 | 7-5-0 | 0.583 | 2W | 4-1-0 |
Buffalo Bills & New Orleans Saints Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| Bills | +1400 Bet | +1400 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Saints | +6600 Bet | +8000 Bet |
Buffalo Bills & New Orleans Saints Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs New Orleans Saints NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, November 25th, 2021 at 8:20 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs New Orleans Saints Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs New Orleans Saints Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 25, 2021 NFL Games
| Matchup |
|---|
| Chicago Bears vs Detroit Lions |
| Las Vegas Raiders vs Dallas Cowboys |