Buffalo Bills vs New Orleans Saints NFL Betting Lines

Odds Preview 504

The Bills will play the Saints on Thursday, November 25th, 2021. The matchup takes place at Mercedes-Benz Superdome. Watch this exciting week 12 matchup at 8:20 pm on NBC.

Best Underdog and Favorite Spread Bets
Underdog

New Orleans Saints
Favorite

Buffalo Bills
+7 -105 Sb3gen2 -6 -125 Sb3gen1
+7 -110 Sb3gen3 -7 -110 Sb3gen3
+6 +105 Sb3gen1 -7 -115 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Thursday. Sb3gen1 has the best favorite Buffalo Bills spread at -6 points. Sb3gen2 has the best underdog New Orleans Saints spread at +7 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
44.5o -112 Sb3gen1 45u -110 Sb3gen3
45o -105 Sb3gen2 45u -115 Sb3gen2
45o -110 Sb3gen3 44.5u -108 Sb3gen1
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 44.5 points laying $112 to win $100. Sb3gen3 has the best under line of 45 u -110.
Best Money Line Bets
Underdog

New Orleans Saints
Favorite

Buffalo Bills
+250 Sb3gen2 -269 Sb3gen1
+235 Sb3gen3 -290 Sb3gen3
+229 Sb3gen1 -300 Sb3gen2
Here are money lines for the outright winner. Favorite Buffalo Bills has a minus value. Lay $269 at Sb3gen1 to win $100. Underdog New Orleans Saints has a positive value. Risk $100 at Sb3gen2 to win $250.

Buffalo Bills vs New Orleans Saints Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Buffalo Bills Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Buffalo Bills

Cached 2021-11-30 20:15:52
New Orleans Saints Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
New Orleans Saints

Cached 2021-11-30 20:15:52

Team Stats

2021 Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 253 187
Total Offensive Yards 4282 3027
Total Rushing Yards 1301 1063
Total Passing Yards 2981 1964
Sacks 21 17
Field Goals 20 / 23 14 / 16
Touchdowns 38 20
Avg Time Of Possession 31:03 28:56
Turnover Ratio +9

2021 New Orleans Saints Team Stats
Stat New Orleans Saints Opponents
Total 1st Downs 211 212
Total Offensive Yards 3403 3781
Total Rushing Yards 1223 1011
Total Passing Yards 2180 2770
Sacks 25 19
Field Goals 10 / 13 21 / 25
Touchdowns 34 27
Avg Time Of Possession 29:34 30:53
Turnover Ratio +4


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Buffalo Bills
5-4-0 3-0-0 7 4 0 0.636 3-2-0 4-2-0 3-2-0
New Orleans Saints
4-4-0 1-2-0 5 6 0 0.455 2-3-0 3-3-0 1-4-0

2021 Buffalo Bills Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
2 Bills vs
Dolphins
BUF 35, MIA 0
09/19/2021
3 TBD vs
Bills
BUF 43, WSH 21
09/26/2021
4 Texans vs
Bills
BUF 40, HOU 0
10/03/2021
5 Bills vs
Chiefs
BUF 38, KC 20
10/10/2021
6 Bills vs
Titans
TEN 34, BUF 31
10/18/2021
7Buffalo Bills ByeN/A
8 Dolphins vs
Bills
BUF 26, MIA 11
10/31/2021
9 Bills vs
Jaguars
JAX 9, BUF 6
11/07/2021
10 Bills vs
Jets
BUF 45, NYJ 17
11/14/2021
11 Colts vs
Bills
IND 41, BUF 15
11/21/2021
12 Bills vs
Saints
BUF 31, NO 6
11/25/2021
13 Patriots vs
Bills
12/06/2021
8:15PM
14 Bills vs
Buccaneers
12/12/2021
4:25PM
15 Panthers vs
Bills
TBD
12/19/2021
16 Bills vs
Patriots
12/26/2021
1:00PM
17 Falcons vs
Bills
01/02/2022
1:00PM

2021 New Orleans Saints Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 Packers vs
Saints
NO 38, GB 3
09/12/2021
2 Saints vs
Panthers
CAR 26, NO 7
09/19/2021
3 Saints vs
Patriots
NO 28, NE 13
09/26/2021
4 Giants vs
Saints
NYG 27, NO 21 (OT)
10/03/2021
5 Saints vs
TBD
NO 33, WSH 22
10/10/2021
6New Orleans Saints ByeN/A
7 Saints vs
Seahawks
NO 13, SEA 10
10/25/2021
8 Buccaneers vs
Saints
NO 36, TB 27
10/31/2021
9 Falcons vs
Saints
ATL 27, NO 25
11/07/2021
10 Saints vs
Titans
TEN 23, NO 21
11/14/2021
11 Saints vs
Eagles
PHI 40, NO 29
11/21/2021
12 Bills vs
Saints
BUF 31, NO 6
11/25/2021
13 Cowboys vs
Saints
12/02/2021
8:20PM
14 Saints vs
Jets
12/12/2021
1:00PM
15 Saints vs
Buccaneers
12/19/2021
8:20PM
16 Dolphins vs
Saints
12/27/2021
8:15PM
17 Panthers vs
Saints
01/02/2022
1:00PM

Other 2021 Week 12 Matchups

MatchupDate & Time
Bears vs
Lions
CHI 16, DET 14
11/25/2021
Raiders vs
Cowboys
LV 36, DAL 33 (OT)
11/25/2021
Bills vs
Saints
BUF 31, NO 6
11/25/2021
Steelers vs
Bengals
CIN 41, PIT 10
11/28/2021
Buccaneers vs
Colts
TB 38, IND 31
11/28/2021
Panthers vs
Dolphins
MIA 33, CAR 10
11/28/2021
Titans vs
Patriots
NE 36, TEN 13
11/28/2021
Eagles vs
Giants
NYG 13, PHI 7
11/28/2021
Falcons vs
Jaguars
ATL 21, JAX 14
11/28/2021
Jets vs
Texans
NYJ 21, HOU 14
11/28/2021
Chargers vs
Broncos
DEN 28, LAC 13
11/28/2021
Rams vs
Packers
GB 36, LAR 28
11/28/2021
Vikings vs
49ers
SF 34, MIN 26
11/28/2021
Browns vs
Ravens
BAL 16, CLE 10
11/28/2021
Seahawks vs
TBD
WSH 17, SEA 15
11/29/2021