Buffalo Bills vs San Francisco 49ers NFL Betting Lines

Odds Preview 159

The Bills will play the 49ers on Monday, December 7th, 2020. The matchup takes place at State Farm Stadium. Watch this exciting week 13 matchup at 8:15 pm on ESPN/ABC.

Best Underdog and Favorite Spread Bets

Underdog Buffalo Bills	Favorite San Francisco 49ers
+2 -108 Sb3gen1	-1.5 -115 Sb3gen2
+2 -110 Sb3gen3	-2 -110 Sb3gen3
+1.5 -105 Sb3gen2	-2 -112 Sb3gen1

SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Monday. Sb3gen2 has the best favorite San Francisco 49ers spread at -1.5 points. Sb3gen1 has the best underdog Buffalo Bills spread at +2 points.

Review our point spread betting tutorial and video for more information.

Best Over and Under Total Lines

Over	Under
47.5o -110 Sb3gen1	47.5u -110 Sb3gen1
47.5o -110 Sb3gen2	47.5u -110 Sb3gen2
47.5o -110 Sb3gen3	47.5u -110 Sb3gen3

The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 47.5 points laying $110 to win $100. Sb3gen1 has the best under line of 47.5 u -110.

Best Money Line Bets

Underdog Buffalo Bills	Favorite San Francisco 49ers
+112 Sb3gen1	+105 Sb3gen3
+105 Sb3gen2	-125 Sb3gen2
-125 Sb3gen3	-132 Sb3gen1

Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay +105 at Sb3gen3 to win $100. Underdog Buffalo Bills has a positive value. Risk $100 at Sb3gen1 to win $112.

Buffalo Bills vs San Francisco 49ers Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Buffalo Bills Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
Buffalo Bills	+550

Cached 2021-10-24 18:41:29
San Francisco 49ers Super Bowl Odds

Super Bowl 2022 Futures Odds

Outcome	SB3Gen
San Francisco 49ers	+4000

Cached 2021-10-24 18:41:29

Team Stats

2020 Buffalo Bills Team Stats

Stat	Buffalo Bills	Opponents
Total 1st Downs	397	351
Total Offensive Yards	6343	5640
Total Rushing Yards	1723	1914
Total Passing Yards	4620	3726
Sacks	38	27
Field Goals	28 / 34	23 / 25
Touchdowns	60	44
Avg Time Of Possession	31:45	28:14
Turnover Ratio	+4

2020 San Francisco 49ers Team Stats

Stat	San Francisco 49ers	Opponents
Total 1st Downs	350	311
Total Offensive Yards	5922	5030
Total Rushing Yards	1889	1703
Total Passing Yards	4033	3327
Sacks	30	39
Field Goals	22 / 26	33 / 37
Touchdowns	45	42
Avg Time Of Possession	31:23	28:36
Turnover Ratio	-11

Team Standings

2020 Regular Season Standings

Team	Conf	Div	W	L	T	Pct	Home	Road	Last 5
xzBuffalo Bills	10-2-0	6-0-0	13	3	0	0.813	7-1-0	6-2-0	5-0-0
San Francisco 49ers	4-8-0	3-3-0	6	10	0	0.375	1-7-0	5-3-0	1-4-0

2020 Buffalo Bills Games & Results

Bye Week: 11

Week	Matchup	Date & Time
1	Jets vs Bills	BUF 27, NYJ 17 09/13/2020
2	Bills vs Dolphins	BUF 31, MIA 28 09/20/2020
3	Rams vs Bills	BUF 35, LAR 32 09/27/2020
4	Bills vs Raiders	BUF 30, LV 23 10/04/2020
5	Bills vs Titans	TEN 42, BUF 16 10/13/2020
6	Chiefs vs Bills	KC 26, BUF 17 10/19/2020
7	Bills vs Jets	BUF 18, NYJ 10 10/25/2020
8	Patriots vs Bills	BUF 24, NE 21 11/01/2020
9	Seahawks vs Bills	BUF 44, SEA 34 11/08/2020
10	Bills vs Cardinals	ARI 32, BUF 30 11/15/2020
11	Buffalo Bills Bye	N/A
12	Chargers vs Bills	BUF 27, LAC 17 11/29/2020
13	Bills vs 49ers	BUF 34, SF 24 12/07/2020
14	Steelers vs Bills	BUF 26, PIT 15 12/13/2020
15	Bills vs Broncos	BUF 48, DEN 19 12/19/2020
16	Bills vs Patriots	BUF 38, NE 9 12/28/2020
17	Dolphins vs Bills	BUF 56, MIA 26 01/03/2021

2020 San Francisco 49ers Games & Results

Bye Week: 11

Week	Matchup	Date & Time
1	Cardinals vs 49ers	ARI 24, SF 20 09/13/2020
2	49ers vs Jets	SF 31, NYJ 13 09/20/2020
3	49ers vs Giants	SF 36, NYG 9 09/27/2020
4	Eagles vs 49ers	PHI 25, SF 20 10/04/2020
5	Dolphins vs 49ers	MIA 43, SF 17 10/11/2020
6	Rams vs 49ers	SF 24, LAR 16 10/18/2020
7	49ers vs Patriots	SF 33, NE 6 10/25/2020
8	49ers vs Seahawks	SEA 37, SF 27 11/01/2020
9	Packers vs 49ers	GB 34, SF 17 11/05/2020
10	49ers vs Saints	NO 27, SF 13 11/15/2020
11	San Francisco 49ers Bye	N/A
12	49ers vs Rams	SF 23, LAR 20 11/29/2020
13	Bills vs 49ers	BUF 34, SF 24 12/07/2020
14	TBD vs 49ers	WSH 23, SF 15 12/13/2020
15	49ers vs Cowboys	DAL 41, SF 33 12/20/2020
16	49ers vs Cardinals	SF 20, ARI 12 12/26/2020
17	Seahawks vs 49ers	SEA 26, SF 23 01/03/2021

Other 2020 Week 13 Matchups

Matchup	Date & Time
Saints vs Falcons	NO 21, ATL 16 12/06/2020
Lions vs Bears	DET 34, CHI 30 12/06/2020
Browns vs Titans	CLE 41, TEN 35 12/06/2020
Bengals vs Dolphins	MIA 19, CIN 7 12/06/2020
Jaguars vs Vikings	MIN 27, JAX 24 (OT) 12/06/2020
Raiders vs Jets	LV 31, NYJ 28 12/06/2020
Colts vs Texans	IND 26, HOU 20 12/06/2020
Rams vs Cardinals	LAR 38, ARI 28 12/06/2020
Giants vs Seahawks	NYG 17, SEA 12 12/06/2020
Eagles vs Packers	GB 30, PHI 16 12/06/2020
Patriots vs Chargers	NE 45, LAC 0 12/06/2020
Broncos vs Chiefs	KC 22, DEN 16 12/06/2020
TBD vs Steelers	WSH 23, PIT 17 12/07/2020
Bills vs 49ers	BUF 34, SF 24 12/07/2020
Cowboys vs Ravens	BAL 34, DAL 17 12/08/2020