Buffalo Bills vs San Francisco 49ers NFL Betting Lines

Odds Preview 159

The Bills will play the 49ers on Monday, December 7th, 2020. The matchup takes place at State Farm Stadium. Watch this exciting week 13 matchup at 8:15 pm on ESPN/ABC.

Best Underdog and Favorite Spread Bets
Underdog
Buffalo Bills
Buffalo Bills
Favorite
San Francisco 49ers
San Francisco 49ers
+2 -108 Betonline -1.5 -115 Bovada
+2 -110 Mybookie -2 -110 Mybookie
+1.5 -105 Bovada -2 -112 Betonline
SportsBetting3.com has analyzed the latest lines from Bovada, Mybookie, and Betonline. Review our "Best Spread Bets" table above to smash the books this Monday. Bovada has the best favorite San Francisco 49ers spread at -1.5 points. Betonline has the best underdog Buffalo Bills spread at +2 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
47.5o -110 Bovada 47.5u -110 Bovada
47.5o -110 Mybookie 47.5u -110 Mybookie
47.5o -110 Betonline 47.5u -110 Betonline
The over under line estimates the combined total of each team's final score. Bovada has the best over line of 47.5 points laying $110 to win $100. Bovada has the best under line of 47.5 u -110.
Best Money Line Bets
Underdog
Buffalo Bills
Buffalo Bills
Favorite
San Francisco 49ers
San Francisco 49ers
+112 Betonline +105 Mybookie
+105 Bovada -125 Bovada
-125 Mybookie -132 Betonline
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay +105 at Mybookie to win $100. Underdog Buffalo Bills has a positive value. Risk $100 at Betonline to win $112.

Buffalo Bills vs San Francisco 49ers Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Buffalo Bills Super Bowl Odds
Super Bowl 56 Futures Odds
Outcomebovada Bovada
Buffalo BillsBuffalo Bills

Cached 2021-04-14 19:48:41
San Francisco 49ers Super Bowl Odds
Super Bowl 56 Futures Odds
Outcomebovada Bovada

Cached 2021-04-14 19:48:41

Team Stats

2020 Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 397 351
Total Offensive Yards 6343 5640
Total Rushing Yards 1723 1914
Total Passing Yards 4620 3726
Sacks 38 27
Field Goals 28 / 34 23 / 25
Touchdowns 60 44
Avg Time Of Possession 31:45 28:14
Turnover Ratio +4

2020 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 350 311
Total Offensive Yards 5922 5030
Total Rushing Yards 1889 1703
Total Passing Yards 4033 3327
Sacks 30 39
Field Goals 22 / 26 33 / 37
Touchdowns 45 42
Avg Time Of Possession 31:23 28:36
Turnover Ratio -11


Team Standings

2020 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
San Francisco 49ersBuffalo Bills 7-2-0 4-0-0 10 3 0 0.769 6-1-0 4-2-0 4-1-0
San Francisco 49ersSan Francisco 49ers 3-6-0 2-2-0 5 8 0 0.385 1-6-0 4-2-0 1-4-0

2020 Buffalo Bills Games & Results

Bye Week: 11
WeekMatchupDate & Time
1 Jets vs
Bills
BUF 27, NYJ 17
09/13/2020
2 Bills vs
Dolphins
BUF 31, MIA 28
09/20/2020
3 Rams vs
Bills
BUF 35, LAR 32
09/27/2020
4 Bills vs
Raiders
BUF 30, LV 23
10/04/2020
5 Bills vs
Titans
TEN 42, BUF 16
10/13/2020
6 Chiefs vs
Bills
KC 26, BUF 17
10/19/2020
7 Bills vs
Jets
BUF 18, NYJ 10
10/25/2020
8 Patriots vs
Bills
BUF 24, NE 21
11/01/2020
9 Seahawks vs
Bills
BUF 44, SEA 34
11/08/2020
10 Bills vs
Cardinals
ARI 32, BUF 30
11/15/2020
11Buffalo Bills ByeN/A
12 Chargers vs
Bills
BUF 27, LAC 17
11/29/2020
13 Bills vs
49ers
BUF 34, SF 24
12/07/2020
14 Steelers vs
Bills
BUF 26, PIT 15
12/13/2020
15 Bills vs
Broncos
BUF 48, DEN 19
12/19/2020
16 Bills vs
Patriots
BUF 38, NE 9
12/28/2020
17 Dolphins vs
Bills
BUF 56, MIA 26
01/03/2021

2020 San Francisco 49ers Games & Results

Bye Week: 11
WeekMatchupDate & Time
1 Cardinals vs
49ers
ARI 24, SF 20
09/13/2020
2 49ers vs
Jets
SF 31, NYJ 13
09/20/2020
3 49ers vs
Giants
SF 36, NYG 9
09/27/2020
4 Eagles vs
49ers
PHI 25, SF 20
10/04/2020
5 Dolphins vs
49ers
MIA 43, SF 17
10/11/2020
6 Rams vs
49ers
SF 24, LAR 16
10/18/2020
7 49ers vs
Patriots
SF 33, NE 6
10/25/2020
8 49ers vs
Seahawks
SEA 37, SF 27
11/01/2020
9 Packers vs
49ers
GB 34, SF 17
11/05/2020
10 49ers vs
Saints
NO 27, SF 13
11/15/2020
11San Francisco 49ers ByeN/A
12 49ers vs
Rams
SF 23, LAR 20
11/29/2020
13 Bills vs
49ers
BUF 34, SF 24
12/07/2020
14 TBD vs
49ers
WSH 23, SF 15
12/13/2020
15 49ers vs
Cowboys
DAL 41, SF 33
12/20/2020
16 49ers vs
Cardinals
SF 20, ARI 12
12/26/2020
17 Seahawks vs
49ers
SEA 26, SF 23
01/03/2021

Other 2020 Week 13 Matchups

MatchupDate & Time
Saints vs
Falcons
NO 21, ATL 16
12/06/2020
Lions vs
Bears
DET 34, CHI 30
12/06/2020
Browns vs
Titans
CLE 41, TEN 35
12/06/2020
Bengals vs
Dolphins
MIA 19, CIN 7
12/06/2020
Jaguars vs
Vikings
MIN 27, JAX 24 (OT)
12/06/2020
Raiders vs
Jets
LV 31, NYJ 28
12/06/2020
Colts vs
Texans
IND 26, HOU 20
12/06/2020
Rams vs
Cardinals
LAR 38, ARI 28
12/06/2020
Giants vs
Seahawks
NYG 17, SEA 12
12/06/2020
Eagles vs
Packers
GB 30, PHI 16
12/06/2020
Patriots vs
Chargers
NE 45, LAC 0
12/06/2020
Broncos vs
Chiefs
KC 22, DEN 16
12/06/2020
TBD vs
Steelers
WSH 23, PIT 17
12/07/2020
Bills vs
49ers
BUF 34, SF 24
12/07/2020
Cowboys vs
Ravens
BAL 34, DAL 17
12/08/2020