The Bills will play the 49ers on Monday, December 7th, 2020. The matchup takes place at State Farm Stadium. Watch this exciting Week 13 matchup at 8:15 pm EST. Check local listings for coverage on ESPN, ABC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Bills at 49ers Odds
| Underdog | Favorite |
|---|
| Over | Under |
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| Underdog | Favorite |
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NFL Odds Example
|
Game |
Bet |
|---|---|
10:07pm EDT | TBD VA |
No VA Point Spread lines available for this game.
Buffalo Bills at San Francisco 49ers Prop Bets
 BetRiversBet |
|
|---|---|
Bills
49ers
12/07/20 8:15pm EST | Pending BetRivers |
Recent Meetings Since 2016
| Week | Game | Result | Margin |
|---|---|---|---|
| 2020 Week 13 | Bills vs 49ers Monday, December 7th, 2020 | BUF 34, SF 24 State Farm Stadium | Bills by 10 |
| 2016 Week 6 | 49ers vs Bills Sunday, October 16th, 2016 | BUF 45, SF 16 Highmark Stadium | Bills by 29 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 13 | 3 | 0 | 0.813 | 501 | 375 | 7-1-0 | 6-2-0 | 6-0-0 | 1.000 | 10-2-0 | 0.833 | 6W | 5-0-0 |
| San Francisco 49ers | 6 | 10 | 0 | 0.375 | 376 | 390 | 1-7-0 | 5-3-0 | 3-3-0 | 0.500 | 4-8-0 | 0.333 | 1L | 1-4-0 |
Buffalo Bills & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| Bills |
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Team | BetRivers |
BetMGM |
|---|---|---|
| 49ers |
Buffalo Bills & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team beting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Monday, December 7th, 2020 at 8:15 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 7, 2020 NFL Games
| Matchup |
|---|
| Washington Football Team vs Pittsburgh Steelers |