The Panthers will play the Cardinals on Sunday, September 14th, 2025. The matchup takes place at State Farm Stadium. Watch this exciting Week 2 matchup at 4:05 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season keeps rolling for the Carolina Panthers and Arizona Cardinals, as they gear up to play an exciting Week 2 matchup at State Farm Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Carolina Panthers have started the 2025-26 season with an initial 91.00 power ranking. The Arizona Cardinals currently have a 98.33 power ranking so far.
- Away Carolina Panthers - Though it's still early in the season, the Carolina Panthers have a 0-1-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Arizona Cardinals - Looking at the Arizona Cardinals heading into Week 2, they currently have a 0-0-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The Carolina Panthers currently rank 17th (10) up to Week 2, with the Arizona Cardinals ranked 11th (20) for points scored in the 2025-26 regular season.
- Points Against - The Carolina Panthers stand 7th (26) in the early weeks of the regular season for points against. The Arizona Cardinals rank 15th (13) for points against.
- Team Records - As Week 2 approaches, the Carolina Panthers have a 0-1-0 record, with the Arizona Cardinals at 1-0-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye mateys! The Carolina Panthers be comin' for the Arizona Cardinals in Week 2!
This crucial matchup be takin' place at State Farm Stadium on Sunday, September 14th, 2025.
According to SportsBetting3.com, the Panthers have a Power Ranking of 91.00, while the Cardinals stand at 98.33.
The Panthers be standin' at 0-1-0, while the Cardinals be boastin' a 1-0-0 record. Bet this game at BetRivers, or BetMGM, review this game's prop bets, and compare the odds below. Arrr!
Best Panthers at Cardinals Odds
| Underdog Carolina Panthers | Favorite Arizona Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog Carolina Panthers | Favorite Arizona Cardinals |
|---|---|
Matchup Odds FAQs
The Arizona Cardinals are -6.5 -120 point spread favorites at BetMGM, while the Carolina Panthers are +6.5 +100 point spread underdogs at BetMGM.
The best over line is 45 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 45 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Arizona Cardinals are the -325 moneyline favorite at BetMGM and the Carolina Panthers are the +260 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Panthers
Cardinals
9/14/25 4:05pm EDT | +6.5 +100-6.5 -120 |
Underdog Carolina Panthers - Carolina Panthers bettors risk $100 to win $100 at +100 odds.
A +6.5 Carolina Panthers underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.
Favorite Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $83.33 at -120 odds.
A -6.5 Arizona Cardinals favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.
Carolina Panthers at Arizona Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Panthers
Cardinals
First Team To Score
9/14/25 4:05pm EDT | +130-165Bet |
Panthers
Cardinals
No Touchdown
To Score 1st Touchdown
9/14/25 4:05pm EDT | +160-225+10000Bet |
Panthers
Cardinals
Game to Overtime
9/14/25 4:05pm EDT | Yes +800No -3000Bet |
Panthers
Cardinals
Safety to be Scored
9/14/25 4:05pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Bryce Young
Interceptions Thrown
CAR at ARI 9/14/25 4:05pm EDT | 0.5 o -1200.5 u -110Bet |
Kyler Murray
Interceptions Thrown
CAR at ARI 9/14/25 4:05pm EDT | 0.5 o +1300.5 u -165Bet |
Bryce Young
Longest Passing Completion
CAR at ARI 9/14/25 4:05pm EDT | 31.5 o -11831.5 u -110Bet |
Kyler Murray
Longest Passing Completion
CAR at ARI 9/14/25 4:05pm EDT | 34.5 o -11034.5 u -120Bet |
| BetMGM | |
Chad Ryland
Total Kicking Points
CAR at ARI 9/14/25 4:05pm EDT | 7.5 o -1157.5 u -115Bet |
Ryan Fitzgerald
Total Kicking Points
CAR at ARI 9/14/25 4:05pm EDT | 6.5 o +1056.5 u -140Bet |
Bryce Young
Total Pass Completions
CAR at ARI 9/14/25 4:05pm EDT | 20.5 o +10520.5 u -135Bet |
Kyler Murray
Total Pass Completions
CAR at ARI 9/14/25 4:05pm EDT | 19.5 o -13519.5 u +100Bet |
| BetMGM | |
Bryce Young
Total Passing Yards
CAR at ARI 9/14/25 4:05pm EDT | 201.5 o -115201.5 u -115Bet |
Kyler Murray
Total Passing Yards
CAR at ARI 9/14/25 4:05pm EDT | 216.5 o -115216.5 u -115Bet |
Bryce Young
Total Touchdown Passes
CAR at ARI 9/14/25 4:05pm EDT | 1.5 o +1851.5 u -250Bet |
Kyler Murray
Total Touchdown Passes
CAR at ARI 9/14/25 4:05pm EDT | 1.5 o +1051.5 u -140Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 2 | Panthers vs Cardinals Sunday, September 14th, 2025 | ARI 27, CAR 22 State Farm Stadium | Cardinals by 5 |
| 2024 Week 16 | Cardinals vs Panthers Sunday, December 22nd, 2024 | CAR 36, ARI 30 (OT) Bank of America Stadium | Panthers by 6 |
| 2022 Week 4 | Cardinals vs Panthers Sunday, October 2nd, 2022 | ARI 26, CAR 16 Bank of America Stadium | Cardinals by 10 |
| 2021 Week 10 | Panthers vs Cardinals Sunday, November 14th, 2021 | CAR 34, ARI 10 State Farm Stadium | Panthers by 24 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arizona Cardinals | 2 | 0 | 0 | 1.000 | 47 | 35 | 1-0-0 | 1-0-0 | 0-0-0 | 0.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
| Carolina Panthers | 0 | 2 | 0 | 0.000 | 32 | 53 | 0-0-0 | 0-2-0 | 0-0-0 | 0.000 | 0-1-0 | 0.000 | 2L | 0-2-0 |
Carolina Panthers & Arizona Cardinals Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Carolina Panthers Futures Odds|
Team | BetMGM |
|---|---|
| Panthers | +30000 Bet |
|
Team | BetMGM |
|---|---|
| Cardinals | +5000 Bet |
Carolina Panthers & Arizona Cardinals Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Carolina Panthers vs Arizona Cardinals NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 14th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Carolina Panthers vs Arizona Cardinals Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs Arizona Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 14, 2025 NFL Games
- Buffalo Bills vs New York Jets - 9/14/25 1:00pm EDT
- Seattle Seahawks vs Pittsburgh Steelers - 9/14/25 1:00pm EDT
- San Francisco 49ers vs New Orleans Saints - 9/14/25 1:00pm EDT
- New York Giants vs Dallas Cowboys - 9/14/25 1:00pm EDT
- New England Patriots vs Miami Dolphins - 9/14/25 1:00pm EDT
- Los Angeles Rams vs Tennessee Titans - 9/14/25 1:00pm EDT
- Jacksonville Jaguars vs Cincinnati Bengals - 9/14/25 1:00pm EDT
- Cleveland Browns vs Baltimore Ravens - 9/14/25 1:00pm EDT
- Chicago Bears vs Detroit Lions - 9/14/25 1:00pm EDT
- Denver Broncos vs Indianapolis Colts - 9/14/25 4:05pm EDT
- Philadelphia Eagles vs Kansas City Chiefs - 9/14/25 4:25pm EDT
- Atlanta Falcons vs Minnesota Vikings - 9/14/25 8:20pm EDT