The Panthers will play the Bills on Sunday, December 19th, 2021. The matchup takes place at Highmark Stadium. Watch this exciting Week 15 matchup at 1:00 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Panthers at Bills Odds
| Underdog | Favorite |
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| Over | Under |
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| Underdog | Favorite |
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NFL Odds Example
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Game |
Bet |
|---|---|
5:07am EDT | TBD OH,US |
No OH,US Point Spread lines available for this game.
Carolina Panthers at Buffalo Bills Prop Bets
 BetMGMBet |
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|---|---|
Panthers
Bills
12/19/21 1:00pm EST | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2021 Week 15 | Panthers vs Bills Sunday, December 19th, 2021 | BUF 31, CAR 14 Highmark Stadium | Bills by 17 |
| 2019 Pre Preseason Week 2 | Bills vs Panthers Friday, August 16th, 2019 | BUF 27, CAR 14 Bank of America Stadium | Bills by 13 |
| 2018 Pre Preseason Week 1 | Panthers vs Bills Thursday, August 9th, 2018 | CAR 28, BUF 23 Highmark Stadium | Panthers by 5 |
| 2017 Week 2 | Bills vs Panthers Sunday, September 17th, 2017 | CAR 9, BUF 3 Bank of America Stadium | Panthers by 6 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 11 | 6 | 0 | 0.647 | 483 | 289 | 6-3-0 | 5-3-0 | 5-1-0 | 0.833 | 7-5-0 | 0.583 | 4W | 4-1-0 |
| Carolina Panthers | 5 | 12 | 0 | 0.294 | 304 | 404 | 2-6-0 | 3-6-0 | 2-4-0 | 0.333 | 3-9-0 | 0.250 | 7L | 0-5-0 |
Carolina Panthers & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Carolina Panthers Futures Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| Panthers | +25000 Bet | +20000 Bet |
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Team | BetMGM |
BetRivers |
|---|---|---|
| Bills | +1400 Bet | +1400 Bet |
Carolina Panthers & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Carolina Panthers vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 19th, 2021 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Carolina Panthers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.