Carolina Panthers vs Buffalo Bills NFL Betting Lines

Odds Preview 549

The Panthers will play the Bills on Sunday, December 19th, 2021. The matchup takes place at Highmark Stadium. Watch this exciting week 15 matchup at 1:00 pm on FOX.

Best Underdog and Favorite Spread Bets
Underdog

Carolina Panthers
Favorite

Buffalo Bills
+14.5 -110 Sb3gen1 -14 -110 Sb3gen3
+14 -105 Sb3gen2 -14 -115 Sb3gen2
+14 -110 Sb3gen3 -14.5 -110 Sb3gen1
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen3 has the best favorite Buffalo Bills spread at -14 points. Sb3gen1 has the best underdog Carolina Panthers spread at +14.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
44o -108 Sb3gen1 44u -110 Sb3gen2
44o -110 Sb3gen2 44u -110 Sb3gen3
44o -110 Sb3gen3 44u -112 Sb3gen1
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 44 points laying $108 to win $100. Sb3gen2 has the best under line of 44 u -110.
Best Money Line Bets
Underdog

Carolina Panthers
Favorite

Buffalo Bills
+550 Sb3gen1 -750 Sb3gen1
+545 Sb3gen3 -750 Sb3gen2
+500 Sb3gen2 -795 Sb3gen3
Here are money lines for the outright winner. Favorite Buffalo Bills has a minus value. Lay $750 at Sb3gen1 to win $100. Underdog Carolina Panthers has a positive value. Risk $100 at Sb3gen1 to win $550.

Carolina Panthers vs Buffalo Bills Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Carolina Panthers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen

Cached 2022-01-26 14:48:15
Buffalo Bills Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Buffalo Bills

Cached 2022-01-26 14:48:15

Team Stats

2021 Carolina Panthers Team Stats
Stat Carolina Panthers Opponents
Total 1st Downs 322 311
Total Offensive Yards 5081 5201
Total Rushing Yards 1842 1935
Total Passing Yards 3239 3266
Sacks 39 52
Field Goals 26 / 29 32 / 37
Touchdowns 32 45
Avg Time Of Possession 30:43 29:31
Turnover Ratio -13

2021 Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 398 285
Total Offensive Yards 6493 4637
Total Rushing Yards 2209 1866
Total Passing Yards 4284 2771
Sacks 42 27
Field Goals 28 / 32 21 / 23
Touchdowns 57 32
Avg Time Of Possession 31:42 28:33
Turnover Ratio +8


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Carolina Panthers
3-9-0 2-4-0 5 12 0 0.294 2-6-0 3-6-0 0-5-0
xz
Buffalo Bills
7-5-0 5-1-0 11 6 0 0.647 6-3-0 5-3-0 4-1-0

2021 Carolina Panthers Games & Results

Bye Week: 13
WeekMatchupDate & Time
1 Jets vs
Panthers
CAR 19, NYJ 14
09/12/2021
2 Saints vs
Panthers
CAR 26, NO 7
09/19/2021
3 Panthers vs
Texans
CAR 24, HOU 9
09/23/2021
4 Panthers vs
Cowboys
DAL 36, CAR 28
10/03/2021
5 Eagles vs
Panthers
PHI 21, CAR 18
10/10/2021
6 Vikings vs
Panthers
MIN 34, CAR 28 (OT)
10/17/2021
7 Panthers vs
Giants
NYG 25, CAR 3
10/24/2021
8 Panthers vs
Falcons
CAR 19, ATL 13
10/31/2021
9 Patriots vs
Panthers
NE 24, CAR 6
11/07/2021
10 Panthers vs
Cardinals
CAR 34, ARI 10
11/14/2021
11 TBD vs
Panthers
WSH 27, CAR 21
11/21/2021
12 Panthers vs
Dolphins
MIA 33, CAR 10
11/28/2021
13Carolina Panthers ByeN/A
14 Falcons vs
Panthers
ATL 29, CAR 21
12/12/2021
15 Panthers vs
Bills
BUF 31, CAR 14
12/19/2021
16 Buccaneers vs
Panthers
TB 32, CAR 6
12/26/2021
17 Panthers vs
Saints
NO 18, CAR 10
01/02/2022

2021 Buffalo Bills Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
2 Bills vs
Dolphins
BUF 35, MIA 0
09/19/2021
3 TBD vs
Bills
BUF 43, WSH 21
09/26/2021
4 Texans vs
Bills
BUF 40, HOU 0
10/03/2021
5 Bills vs
Chiefs
BUF 38, KC 20
10/10/2021
6 Bills vs
Titans
TEN 34, BUF 31
10/18/2021
7Buffalo Bills ByeN/A
8 Dolphins vs
Bills
BUF 26, MIA 11
10/31/2021
9 Bills vs
Jaguars
JAX 9, BUF 6
11/07/2021
10 Bills vs
Jets
BUF 45, NYJ 17
11/14/2021
11 Colts vs
Bills
IND 41, BUF 15
11/21/2021
12 Bills vs
Saints
BUF 31, NO 6
11/25/2021
13 Patriots vs
Bills
NE 14, BUF 10
12/06/2021
14 Bills vs
Buccaneers
TB 33, BUF 27 (OT)
12/12/2021
15 Panthers vs
Bills
BUF 31, CAR 14
12/19/2021
16 Bills vs
Patriots
BUF 33, NE 21
12/26/2021
17 Falcons vs
Bills
BUF 29, ATL 15
01/02/2022

Other 2021 Week 15 Matchups

MatchupDate & Time
Chiefs vs
Chargers
KC 34, LAC 28 (OT)
12/16/2021
Patriots vs
Colts
IND 27, NE 17
12/18/2021
Panthers vs
Bills
BUF 31, CAR 14
12/19/2021
Cardinals vs
Lions
DET 30, ARI 12
12/19/2021
Jets vs
Dolphins
MIA 31, NYJ 24
12/19/2021
Cowboys vs
Giants
DAL 21, NYG 6
12/19/2021
Titans vs
Steelers
PIT 19, TEN 13
12/19/2021
Texans vs
Jaguars
HOU 30, JAX 16
12/19/2021
Bengals vs
Broncos
CIN 15, DEN 10
12/19/2021
Falcons vs
49ers
SF 31, ATL 13
12/19/2021
Packers vs
Ravens
GB 31, BAL 30
12/19/2021
Saints vs
Buccaneers
NO 9, TB 0
12/19/2021
Raiders vs
Browns
LV 16, CLE 14
12/20/2021
Vikings vs
Bears
MIN 17, CHI 9
12/20/2021
Seahawks vs
Rams
LAR 20, SEA 10
12/21/2021
TBD vs
Eagles
PHI 27, WSH 17
12/21/2021