Carolina Panthers vs Buffalo Bills Odds

The Panthers will play the Bills on Sunday, December 19th, 2021. The matchup takes place at Highmark Stadium. Watch this exciting Week 15 matchup at 1:00 pm EST. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Best Panthers at Bills Odds


Best Point Spread Betting Odds
Underdog

Favorite

Point Spread odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
Total odds are updating, please check back soon.

Best Moneyline Betting Odds
Underdog

Favorite

Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained

Game

Bet
6:34pm EST
TBD VA
VA Odds Pending
No VA Point Spread lines available for this game.

Carolina Panthers at Buffalo Bills Prop Bets

NFL Prop Bets
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Panthers
Bills
12/19/21 1:00pm EST
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Recent Meetings Since 2017

Recent Meetings Since 2017
WeekGameResultMargin
2021
Week 15
Panthers vs Bills
Sunday, December 19th, 2021
BUF 31, CAR 14
Highmark Stadium
Bills by 17
2019
Pre Preseason Week 2
Bills vs Panthers
Friday, August 16th, 2019
BUF 27, CAR 14
Bank of America Stadium
Bills by 13
2018
Pre Preseason Week 1
Panthers vs Bills
Thursday, August 9th, 2018
CAR 28, BUF 23
Highmark Stadium
Panthers by 5
2017
Week 2
Bills vs Panthers
Sunday, September 17th, 2017
CAR 9, BUF 3
Bank of America Stadium
Panthers by 6

Team Standings

2021-2022 NFL Regular Season Standings - Carolina Panthers, Buffalo Bills
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Buffalo Bills11600.6474832896-3-05-3-05-1-00.8337-5-00.5834W4-1-0
Carolina Panthers51200.2943044042-6-03-6-02-4-00.3333-9-00.2507L0-5-0

Carolina Panthers & Buffalo Bills Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Carolina Panthers Futures Odds

No Super Bowl TM Carolina Panthers YR: futures available

Buffalo Bills Futures Odds

No Super Bowl TM Buffalo Bills YR: futures available

Carolina Panthers & Buffalo Bills Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Carolina Panthers vs Buffalo Bills NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 19th, 2021 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Carolina Panthers vs Buffalo Bills Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs Buffalo Bills Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other December 19, 2021 NFL Games

Matchup
Washington Football Team vs
Philadelphia Eagles
Arizona Cardinals vs
Detroit Lions
Houston Texans vs
Jacksonville Jaguars
Tennessee Titans vs
Pittsburgh Steelers
Dallas Cowboys vs
New York Giants
New York Jets vs
Miami Dolphins
Atlanta Falcons vs
San Francisco 49ers
Cincinnati Bengals vs
Denver Broncos
Green Bay Packers vs
Baltimore Ravens
Seattle Seahawks vs
Los Angeles Rams
New Orleans Saints vs
Tampa Bay Buccaneers
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