The Lions will play the Bills on Thursday, September 17th, 2026. The matchup takes place at Highmark Stadium. Watch this exciting Week 2 matchup at 8:15 pm EDT. Check local listings for coverage on Prime Video.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2026-27 NFL regular season keeps rolling for the Detroit Lions and Buffalo Bills, as they gear up to play an exciting Week 2 matchup at Highmark Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Detroit Lions have started the 2026-27 season with an initial 97.00 power ranking. The Buffalo Bills currently have a 97.67 power ranking so far.
- Away Detroit Lions - Though it's still early in the season, the Detroit Lions have a 0-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Buffalo Bills - Looking at the Buffalo Bills heading into Week 2, they currently have a 0-0-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The Detroit Lions currently rank 7th (31) up to Week 2, with the Buffalo Bills ranked 4th (36) for points scored in the 2026-27 regular season.
- Points Against - The Detroit Lions stand 8th (30) in the early weeks of the regular season for points against. The Buffalo Bills rank 7th (31) for points against.
- Team Records - As Week 2 approaches, the Detroit Lions have a 1-0-0 record, with the Buffalo Bills at 1-0-0 for the 2026-27 NFL regular season.
Best Lions at Bills Odds
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NFL Odds Example
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Detroit Lions at Buffalo Bills Prop Bets
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Lions
Bills
9/17/26 8:15pm EDT | Pending |
Recent Meetings Since 2022
| Week | Game | Result | Margin |
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| 2026 Week 2 | Lions vs Bills Thursday, September 17th, 2026 | BUF 41, DET 31 Highmark Stadium | Bills by 10 |
| 2024 Week 15 | Bills vs Lions Sunday, December 15th, 2024 | BUF 48, DET 42 Ford Field | Bills by 6 |
| 2022 Week 12 | Bills vs Lions Thursday, November 24th, 2022 | BUF 28, DET 25 Ford Field | Bills by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| Buffalo Bills | 3 | 1 | 0 | 0.750 | 127 | 107 | 2-1-0 | 1-0-0 | 0-1-0 | 0.000 | 2-1-0 | 0.667 | 1L | 3-1-0 |
| Detroit Lions | 2 | 2 | 0 | 0.500 | 119 | 127 | 2-0-0 | 0-2-0 | 0-0-0 | 0.000 | 1-1-0 | 0.500 | 1L | 2-2-0 |
Detroit Lions & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Detroit Lions Futures OddsNo Super Bowl TM Detroit Lions YR: futures available
Buffalo Bills Futures OddsNo Super Bowl TM Buffalo Bills YR: futures available
Detroit Lions & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Detroit Lions vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 17th, 2026 at 8:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Detroit Lions vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Detroit Lions vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.