Indianapolis Colts vs Buffalo Bills Odds

The Colts will play the Bills on Sunday, November 21st, 2021. The matchup takes place at Highmark Stadium - Orchard Park, NY. Watch this exciting Week 11 matchup at 1:00 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.


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Total
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Moneyline
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Recent Meetings Since 2017

WeekGameResultMargin
2022
Pre Wk 1
Colts vs Bills
Saturday, August 13th, 2022
Preseason

Highmark Stadium - Orchard Park, NY
Tie
2021
Wk 11
Colts vs Bills
Sunday, November 21st, 2021
IND 41, BUF 15
Highmark Stadium - Orchard Park, NY
Colts by 26
2020
Wk wc
Colts vs Bills
Saturday, January 9th, 2021
AFC Wild Card Playoffs
BUF 27, IND 24
Highmark Stadium - Orchard Park, NY
Bills by 3
2020
Pre Wk 3
Colts vs Bills
Saturday, August 29th, 2020
Preseason
Canceled
Highmark Stadium - Orchard Park, NY
Tie
2019
Pre Wk 1
Colts vs Bills
Thursday, August 8th, 2019
Preseason
BUF 24, IND 16
Highmark Stadium - Orchard Park, NY
Bills by 8
2018
Wk 7
Bills vs Colts
Sunday, October 21st, 2018
IND 37, BUF 5
Lucas Oil Stadium - Indianapolis, IN
Colts by 32
2017
Wk 14
Colts vs Bills
Sunday, December 10th, 2017
BUF 13, IND 7 (OT)
Highmark Stadium - Orchard Park, NY
Bills by 6

Regular Season Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Indianapolis Colts
7-5-0 3-3-0 9 8 0 0.529 4-5-0 5-3-0 3-2-0
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Buffalo Bills
7-5-0 5-1-0 11 6 0 0.647 6-3-0 5-3-0 4-1-0

Team Stats

Indianapolis Colts Team Stats
Stat Indianapolis Colts Opponents
Total 1st Downs 354 334
Total Offensive Yards 5901 5834
Total Rushing Yards 2540 1854
Total Passing Yards 3361 3980
Sacks 33 32
Field Goals 29 / 35 22 / 27
Touchdowns 52 43
Avg Time Of Possession 32:03 28:33
Turnover Ratio +14

Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 398 285
Total Offensive Yards 6493 4637
Total Rushing Yards 2209 1866
Total Passing Yards 4284 2771
Sacks 42 27
Field Goals 28 / 32 21 / 23
Touchdowns 57 32
Avg Time Of Possession 31:42 28:33
Turnover Ratio +8

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Indianapolis Colts Futures Odds
2023 Super Bowl Winner Odds

Team
BetRivers BetRivers
Indianapolis Colts
Buffalo Bills Futures Odds
2023 Super Bowl Winner Odds

Team
BetRivers BetRivers
Buffalo Bills

2021 Indianapolis Colts Games & Results

WeekMatchupDate & Time
Pre 1Panthers vs
Colts
Preseason
IND 21, CAR 18
Sunday, August 15th, 2021
Pre 2Colts vs
Vikings
Preseason
IND 12, MIN 10
Saturday, August 21st, 2021
Pre 3Colts vs
Lions
Preseason
IND 27, DET 17
Friday, August 27th, 2021
1Seahawks vs
Colts
SEA 28, IND 16
Sunday, September 12th, 2021
2Rams vs
Colts
LAR 27, IND 24
Sunday, September 19th, 2021
3Colts vs
Titans
TEN 25, IND 16
Sunday, September 26th, 2021
4Colts vs
Dolphins
IND 27, MIA 17
Sunday, October 3rd, 2021
5Colts vs
Ravens
BAL 31, IND 25 (OT)
Monday, October 11th, 2021
6Texans vs
Colts
IND 31, HOU 3
Sunday, October 17th, 2021
7Colts vs
49ers
IND 30, SF 18
Sunday, October 24th, 2021
8Titans vs
Colts
TEN 34, IND 31 (OT)
Sunday, October 31st, 2021
9Jets vs
Colts
IND 45, NYJ 30
Thursday, November 4th, 2021
10Jaguars vs
Colts
IND 23, JAX 17
Sunday, November 14th, 2021
11Colts vs
Bills
IND 41, BUF 15
Sunday, November 21st, 2021
12Buccaneers vs
Colts
TB 38, IND 31
Sunday, November 28th, 2021
13Colts vs
Texans
IND 31, HOU 0
Sunday, December 5th, 2021
15Patriots vs
Colts
IND 27, NE 17
Saturday, December 18th, 2021
16Colts vs
Cardinals
IND 22, ARI 16
Saturday, December 25th, 2021
17Raiders vs
Colts
LV 23, IND 20
Sunday, January 2nd, 2022
18Colts vs
Jaguars
JAX 26, IND 11
Sunday, January 9th, 2022

2021 Buffalo Bills Games & Results

WeekMatchupDate & Time
Pre 1Bills vs
Lions
Preseason
BUF 16, DET 15
Friday, August 13th, 2021
Pre 2Bills vs
Bears
Preseason
BUF 41, CHI 15
Saturday, August 21st, 2021
Pre 3Packers vs
Bills
Preseason
BUF 19, GB 0
Saturday, August 28th, 2021
1Steelers vs
Bills
PIT 23, BUF 16
Sunday, September 12th, 2021
2Bills vs
Dolphins
BUF 35, MIA 0
Sunday, September 19th, 2021
3TBD vs
Bills
BUF 43, WSH 21
Sunday, September 26th, 2021
4Texans vs
Bills
BUF 40, HOU 0
Sunday, October 3rd, 2021
5Bills vs
Chiefs
BUF 38, KC 20
Sunday, October 10th, 2021
6Bills vs
Titans
TEN 34, BUF 31
Monday, October 18th, 2021
8Dolphins vs
Bills
BUF 26, MIA 11
Sunday, October 31st, 2021
9Bills vs
Jaguars
JAX 9, BUF 6
Sunday, November 7th, 2021
10Bills vs
Jets
BUF 45, NYJ 17
Sunday, November 14th, 2021
11Colts vs
Bills
IND 41, BUF 15
Sunday, November 21st, 2021
12Bills vs
Saints
BUF 31, NO 6
Thursday, November 25th, 2021
13Patriots vs
Bills
NE 14, BUF 10
Monday, December 6th, 2021
14Bills vs
Buccaneers
TB 33, BUF 27 (OT)
Sunday, December 12th, 2021
15Panthers vs
Bills
BUF 31, CAR 14
Sunday, December 19th, 2021
16Bills vs
Patriots
BUF 33, NE 21
Sunday, December 26th, 2021
17Bills
Bye Week
17Falcons vs
Bills
BUF 29, ATL 15
Sunday, January 2nd, 2022
18Jets vs
Bills
BUF 27, NYJ 10
Sunday, January 9th, 2022
Patriots vs
Bills
AFC Wild Card Playoffs
BUF 47, NE 17
Saturday, January 15th, 2022
Bills vs
Chiefs
AFC Divisional Playoffs
KC 42, BUF 36 (OT)
Sunday, January 23rd, 2022

Current NFL Matchup Lines

Next 10 NFL Matchups
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Game
BetRivers BetRivers
Play
Bills
Rams
9/08/22 8:20pm EDT
Saints
Falcons
9/11/22 1:00pm EDT
Jaguars
commanders
9/11/22 1:00pm EDT
Ravens
Jets
9/11/22 1:00pm EDT
Patriots
Dolphins
9/11/22 1:00pm EDT
Colts
Texans
9/11/22 1:00pm EDT
Eagles
Lions
9/11/22 1:00pm EDT
Steelers
Bengals
9/11/22 1:00pm EDT
49ers
Bears
9/11/22 1:00pm EDT
Browns
Panthers
9/11/22 1:00pm EDT
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