Indianapolis Colts vs Buffalo Bills Odds

The Colts will play the Bills on Sunday, November 21st, 2021. The matchup takes place at Highmark Stadium - Orchard Park, NY. Watch this exciting Week 11 matchup at 1:00 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.

**Point Spread**
Underdog	Favorite

Point Spread odds are updating, please check back soon.

**Total**
Over	Under

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**Moneyline**
Underdog	Favorite

Moneyline odds are updating, please check back soon.

Recent Meetings Since 2017

Week	Game	Result	Margin
2022 Pre Wk 1	Colts vs Bills Saturday, August 13th, 2022 Preseason	Highmark Stadium - Orchard Park, NY	Tie
2021 Wk 11	Colts vs Bills Sunday, November 21st, 2021	IND 41, BUF 15 Highmark Stadium - Orchard Park, NY	Colts by 26
2020 Wk wc	Colts vs Bills Saturday, January 9th, 2021 AFC Wild Card Playoffs	BUF 27, IND 24 Highmark Stadium - Orchard Park, NY	Bills by 3
2020 Pre Wk 3	Colts vs Bills Saturday, August 29th, 2020 Preseason	Canceled Highmark Stadium - Orchard Park, NY	Tie
2019 Pre Wk 1	Colts vs Bills Thursday, August 8th, 2019 Preseason	BUF 24, IND 16 Highmark Stadium - Orchard Park, NY	Bills by 8
2018 Wk 7	Bills vs Colts Sunday, October 21st, 2018	IND 37, BUF 5 Lucas Oil Stadium - Indianapolis, IN	Colts by 32
2017 Wk 14	Colts vs Bills Sunday, December 10th, 2017	BUF 13, IND 7 (OT) Highmark Stadium - Orchard Park, NY	Bills by 6

Regular Season Team Standings

**2021 Regular Season Standings**
Team	Conf	Div	W	L	T	Pct	Home	Road	Last 5
Indianapolis Colts	7-5-0	3-3-0	9	8	0	0.529	4-5-0	5-3-0	3-2-0
xz Buffalo Bills	7-5-0	5-1-0	11	6	0	0.647	6-3-0	5-3-0	4-1-0

Team Stats

**Indianapolis Colts Team Stats**
Stat	Indianapolis Colts	Opponents
Total 1st Downs	354	334
Total Offensive Yards	5901	5834
Total Rushing Yards	2540	1854
Total Passing Yards	3361	3980
Sacks	33	32
Field Goals	29 / 35	22 / 27
Touchdowns	52	43
Avg Time Of Possession	32:03	28:33
Turnover Ratio	+14

**Buffalo Bills Team Stats**
Stat	Buffalo Bills	Opponents
Total 1st Downs	398	285
Total Offensive Yards	6493	4637
Total Rushing Yards	2209	1866
Total Passing Yards	4284	2771
Sacks	42	27
Field Goals	28 / 32	21 / 23
Touchdowns	57	32
Avg Time Of Possession	31:42	28:33
Turnover Ratio	+8

Team Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Indianapolis Colts Futures Odds

2023 Super Bowl Winner Odds
Team	BetRivers
Indianapolis Colts	+2200 Play

Buffalo Bills Futures Odds

2023 Super Bowl Winner Odds
Team	BetRivers
Buffalo Bills	+650 Play

2021 Indianapolis Colts Games & Results

Week	Matchup	Date & Time
Pre 1	Panthers vs Colts Preseason	IND 21, CAR 18 Sunday, August 15th, 2021
Pre 2	Colts vs Vikings Preseason	IND 12, MIN 10 Saturday, August 21st, 2021
Pre 3	Colts vs Lions Preseason	IND 27, DET 17 Friday, August 27th, 2021
1	Seahawks vs Colts	SEA 28, IND 16 Sunday, September 12th, 2021
2	Rams vs Colts	LAR 27, IND 24 Sunday, September 19th, 2021
3	Colts vs Titans	TEN 25, IND 16 Sunday, September 26th, 2021
4	Colts vs Dolphins	IND 27, MIA 17 Sunday, October 3rd, 2021
5	Colts vs Ravens	BAL 31, IND 25 (OT) Monday, October 11th, 2021
6	Texans vs Colts	IND 31, HOU 3 Sunday, October 17th, 2021
7	Colts vs 49ers	IND 30, SF 18 Sunday, October 24th, 2021
8	Titans vs Colts	TEN 34, IND 31 (OT) Sunday, October 31st, 2021
9	Jets vs Colts	IND 45, NYJ 30 Thursday, November 4th, 2021
10	Jaguars vs Colts	IND 23, JAX 17 Sunday, November 14th, 2021
11	Colts vs Bills	IND 41, BUF 15 Sunday, November 21st, 2021
12	Buccaneers vs Colts	TB 38, IND 31 Sunday, November 28th, 2021
13	Colts vs Texans	IND 31, HOU 0 Sunday, December 5th, 2021
15	Patriots vs Colts	IND 27, NE 17 Saturday, December 18th, 2021
16	Colts vs Cardinals	IND 22, ARI 16 Saturday, December 25th, 2021
17	Raiders vs Colts	LV 23, IND 20 Sunday, January 2nd, 2022
18	Colts vs Jaguars	JAX 26, IND 11 Sunday, January 9th, 2022

2021 Buffalo Bills Games & Results

Week	Matchup	Date & Time
Pre 1	Bills vs Lions Preseason	BUF 16, DET 15 Friday, August 13th, 2021
Pre 2	Bills vs Bears Preseason	BUF 41, CHI 15 Saturday, August 21st, 2021
Pre 3	Packers vs Bills Preseason	BUF 19, GB 0 Saturday, August 28th, 2021
1	Steelers vs Bills	PIT 23, BUF 16 Sunday, September 12th, 2021
2	Bills vs Dolphins	BUF 35, MIA 0 Sunday, September 19th, 2021
3	TBD vs Bills	BUF 43, WSH 21 Sunday, September 26th, 2021
4	Texans vs Bills	BUF 40, HOU 0 Sunday, October 3rd, 2021
5	Bills vs Chiefs	BUF 38, KC 20 Sunday, October 10th, 2021
6	Bills vs Titans	TEN 34, BUF 31 Monday, October 18th, 2021
8	Dolphins vs Bills	BUF 26, MIA 11 Sunday, October 31st, 2021
9	Bills vs Jaguars	JAX 9, BUF 6 Sunday, November 7th, 2021
10	Bills vs Jets	BUF 45, NYJ 17 Sunday, November 14th, 2021
11	Colts vs Bills	IND 41, BUF 15 Sunday, November 21st, 2021
12	Bills vs Saints	BUF 31, NO 6 Thursday, November 25th, 2021
13	Patriots vs Bills	NE 14, BUF 10 Monday, December 6th, 2021
14	Bills vs Buccaneers	TB 33, BUF 27 (OT) Sunday, December 12th, 2021
15	Panthers vs Bills	BUF 31, CAR 14 Sunday, December 19th, 2021
16	Bills vs Patriots	BUF 33, NE 21 Sunday, December 26th, 2021
17	Bills Bye Week
17	Falcons vs Bills	BUF 29, ATL 15 Sunday, January 2nd, 2022
18	Jets vs Bills	BUF 27, NYJ 10 Sunday, January 9th, 2022
	Patriots vs Bills AFC Wild Card Playoffs	BUF 47, NE 17 Saturday, January 15th, 2022
	Bills vs Chiefs AFC Divisional Playoffs	KC 42, BUF 36 (OT) Sunday, January 23rd, 2022

Current NFL Matchup Lines

Next 10 NFL Matchups
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Game	BetRivers Play
Bills Rams 9/08/22 8:20pm EDT	+1 -117 -1 -105
Saints Falcons 9/11/22 1:00pm EDT	-5 -110 +5 -110
Jaguars commanders 9/11/22 1:00pm EDT	+4 -110 -4 -110
Ravens Jets 9/11/22 1:00pm EDT	-5.5 -110 +5.5 -110
Patriots Dolphins 9/11/22 1:00pm EDT	+2.5 -110 -2.5 -112
Colts Texans 9/11/22 1:00pm EDT	-8.5 -105 +8.5 -115
Eagles Lions 9/11/22 1:00pm EDT	-4 -110 +4 -110
Steelers Bengals 9/11/22 1:00pm EDT	+6.5 -110 -6.5 -110
49ers Bears 9/11/22 1:00pm EDT	-6.5 -110 +6.5 -110
Browns Panthers 9/11/22 1:00pm EDT	-2.5 -120 +2.5 -103

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