The Colts will play the 49ers on Sunday, October 24th, 2021. The matchup takes place at Levi's Stadium. Watch this exciting Week 7 matchup at 8:20 pm EDT. Check local listings for coverage on NBC.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Colts at 49ers Odds
| Underdog | Favorite |
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| Over | Under |
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| Underdog | Favorite |
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NFL Odds Example
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Game |
Bet |
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12:08am EDT | TBD VA |
No VA Point Spread lines available for this game.
Indianapolis Colts at San Francisco 49ers Prop Bets
 BetRiversBet |
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|---|---|
Colts
49ers
10/24/21 8:20pm EDT | Pending BetRivers |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2021 Week 7 | Colts vs 49ers Sunday, October 24th, 2021 | IND 30, SF 18 Levi's Stadium | Colts by 12 |
| 2018 Pre Preseason Week 3 | 49ers vs Colts Saturday, August 25th, 2018 | IND 23, SF 17 Lucas Oil Stadium | Colts by 6 |
| 2017 Week 5 | 49ers vs Colts Sunday, October 8th, 2017 | IND 26, SF 23 (OT) Lucas Oil Stadium | Colts by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - San Francisco 49ers | 10 | 7 | 0 | 0.588 | 427 | 365 | 4-4-0 | 6-3-0 | 2-4-0 | 0.333 | 7-5-0 | 0.583 | 2W | 4-1-0 |
| Indianapolis Colts | 9 | 8 | 0 | 0.529 | 451 | 365 | 4-5-0 | 5-3-0 | 3-3-0 | 0.500 | 7-5-0 | 0.583 | 2L | 3-2-0 |
Indianapolis Colts & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Indianapolis Colts Futures Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| Colts |
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Team | BetRivers |
BetMGM |
|---|---|---|
| 49ers |
Indianapolis Colts & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team beting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Indianapolis Colts vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 24th, 2021 at 8:20 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Indianapolis Colts vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Indianapolis Colts vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.