Indianapolis Colts vs San Francisco 49ers NFL Betting Lines

Odds Preview 436

The Colts will play the 49ers on Sunday, October 24th, 2021. The matchup takes place at Levi's Stadium. Watch this exciting week 7 matchup at 8:20 pm on NBC.

Best Underdog and Favorite Spread Bets
Underdog

Indianapolis Colts
Favorite

San Francisco 49ers
+3.5 -115 Sb3gen1 -3.5 +100 Sb3gen2
+3.5 -115 Sb3gen3 -3.5 -105 Sb3gen1
+3.5 -120 Sb3gen2 -3.5 -105 Sb3gen3
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen2 has the best favorite San Francisco 49ers spread at -3.5 points. Sb3gen1 has the best underdog Indianapolis Colts spread at +3.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
41.5o -110 Sb3gen1 42u -110 Sb3gen3
41.5o -110 Sb3gen2 41.5u -110 Sb3gen1
42o -110 Sb3gen3 41.5u -110 Sb3gen2
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 41.5 points laying $110 to win $100. Sb3gen3 has the best under line of 42 u -110.
Best Money Line Bets
Underdog

Indianapolis Colts
Favorite

San Francisco 49ers
+155 Sb3gen2 -170 Sb3gen1
+150 Sb3gen1 -180 Sb3gen2
+150 Sb3gen3 -180 Sb3gen3
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $170 at Sb3gen1 to win $100. Underdog Indianapolis Colts has a positive value. Risk $100 at Sb3gen2 to win $155.

Indianapolis Colts vs San Francisco 49ers Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Indianapolis Colts Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Indianapolis Colts

Cached 2021-12-05 01:43:19
San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ers

Cached 2021-12-05 01:43:19

Team Stats

2021 Indianapolis Colts Team Stats
Stat Indianapolis Colts Opponents
Total 1st Downs 264 248
Total Offensive Yards 4396 4306
Total Rushing Yards 1734 1370
Total Passing Yards 2662 2936
Sacks 25 21
Field Goals 21 / 24 13 / 16
Touchdowns 40 35
Avg Time Of Possession 31:49 29:02
Turnover Ratio +12

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 236 212
Total Offensive Yards 4016 3506
Total Rushing Yards 1440 1226
Total Passing Yards 2576 2280
Sacks 24 21
Field Goals 17 / 21 13 / 16
Touchdowns 33 30
Avg Time Of Possession 31:04 28:55
Turnover Ratio -4


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Indianapolis Colts
5-3-0 2-2-0 6 6 0 0.500 3-4-0 3-2-0 3-2-0
San Francisco 49ers
5-4-0 1-3-0 6 5 0 0.545 2-4-0 4-1-0 4-1-0

2021 Indianapolis Colts Games & Results

Bye Week: 14
WeekMatchupDate & Time
1 Seahawks vs
Colts
SEA 28, IND 16
09/12/2021
2 Rams vs
Colts
LAR 27, IND 24
09/19/2021
3 Colts vs
Titans
TEN 25, IND 16
09/26/2021
4 Colts vs
Dolphins
IND 27, MIA 17
10/03/2021
5 Colts vs
Ravens
BAL 31, IND 25 (OT)
10/11/2021
6 Texans vs
Colts
IND 31, HOU 3
10/17/2021
7 Colts vs
49ers
IND 30, SF 18
10/24/2021
8 Titans vs
Colts
TEN 34, IND 31 (OT)
10/31/2021
9 Jets vs
Colts
IND 45, NYJ 30
11/04/2021
10 Jaguars vs
Colts
IND 23, JAX 17
11/14/2021
11 Colts vs
Bills
IND 41, BUF 15
11/21/2021
12 Buccaneers vs
Colts
TB 38, IND 31
11/28/2021
13 Colts vs
Texans
12/05/2021
1:00PM
14Indianapolis Colts ByeN/A
15 Patriots vs
Colts
TBD
12/19/2021
16 Colts vs
Cardinals
12/25/2021
8:15PM
17 Raiders vs
Colts
01/02/2022
1:00PM

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
GB 30, SF 28
09/26/2021
4 Seahawks vs
49ers
SEA 28, SF 21
10/03/2021
5 49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
IND 30, SF 18
10/24/2021
8 49ers vs
Bears
SF 33, CHI 22
10/31/2021
9 Cardinals vs
49ers
ARI 31, SF 17
11/07/2021
10 Rams vs
49ers
SF 31, LAR 10
11/15/2021
11 49ers vs
Jaguars
SF 30, JAX 10
11/21/2021
12 Vikings vs
49ers
SF 34, MIN 26
11/28/2021
13 49ers vs
Seahawks
12/05/2021
8:20PM
14 49ers vs
Bengals
12/12/2021
1:00PM
15 Falcons vs
49ers
12/19/2021
4:05PM
16 49ers vs
Titans
12/23/2021
8:20PM
17 Texans vs
49ers
01/02/2022
4:05PM

Other 2021 Week 7 Matchups

MatchupDate & Time
Broncos vs
Browns
CLE 17, DEN 14
10/21/2021
TBD vs
Packers
GB 24, WSH 10
10/24/2021
Chiefs vs
Titans
TEN 27, KC 3
10/24/2021
Falcons vs
Dolphins
ATL 30, MIA 28
10/24/2021
Jets vs
Patriots
NE 54, NYJ 13
10/24/2021
Panthers vs
Giants
NYG 25, CAR 3
10/24/2021
Bengals vs
Ravens
CIN 41, BAL 17
10/24/2021
Eagles vs
Raiders
LV 33, PHI 22
10/24/2021
Lions vs
Rams
LAR 28, DET 19
10/24/2021
Texans vs
Cardinals
ARI 31, HOU 5
10/24/2021
Bears vs
Buccaneers
TB 38, CHI 3
10/24/2021
Colts vs
49ers
IND 30, SF 18
10/24/2021
Saints vs
Seahawks
NO 13, SEA 10
10/25/2021