The Chargers will play the 49ers on Saturday, August 23rd, 2025. The matchup takes place at Levi's Stadium. Watch this exciting preseason matchup at 8:30 pm EDT. Check local listings for coverage on ESPN Unlmtd.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL preseason is underway for the Los Angeles Chargers and San Francisco 49ers. Let's review each team's stats in anticipation of their upcoming matchup. Preseason results do not affect a team's chances of making the playoffs. Remember, the regular season begins soon!
- SportsBetting3.com Power Rankings - The Los Angeles Chargers currently have a 98.33 preseason power ranking (91.67 for the 2024 preseason). Contrast this to the San Francisco 49ers who'll play this matchup with a 91.67 preseason power ranking (93.00 in 2024).
- Away Los Angeles Chargers - The Los Angeles Chargers currently have a 1-1-0 record as an away team (1-0-0 in 2024). They now rank 2nd for away team wins in the preseason standings.
- Home San Francisco 49ers - The San Francisco 49ers currently have a 0-1-0 record as a home team (1-0-0 in 2024). They now rank 3rd for home team wins in the preseason standings.
- Points Scored - The Los Angeles Chargers rank 1st (83) in the preseason, with the San Francisco 49ers ranked 20th (31) for points scored in the 2025 preseason.
- Points Against - The Los Angeles Chargers are 11th (43) in the preseason for points against. The San Francisco 49ers stand 6th (49) in the 2025 preseason for points against.
- Team Records - The Los Angeles Chargers have a 2-1-0 preseason record, with the San Francisco 49ers at 1-1-0. Last year, the Los Angeles Chargers had a 1-2-0 preseason record, with the San Francisco 49ers finishing with a 1-1-1 standing.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Chargers be sailin' to Levi's Stadium for battle. Preseason scuffle... Chargers stand tall at 2-1-0 while them 49ers be at 1-1-0. SportsBetting3.com.
Ye best be ready for a showdown on August 23rd. Bet on this game... review the odds below. The Chargers be lookin' to plunder victory from the 49ers. Aye!
Best Chargers at 49ers Odds
| Underdog San Francisco 49ers | Favorite Los Angeles Chargers |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Los Angeles Chargers |
|---|---|
Matchup Odds FAQs
The Los Angeles Chargers are -2.5 -110 point spread favorites at BetMGM, while the San Francisco 49ers are +2.5 -110 point spread underdogs at BetMGM.
The best over line is 35.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 35.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Los Angeles Chargers are the -150 moneyline favorite at BetMGM and the San Francisco 49ers are the +125 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Chargers
49ers
8/23/25 8:30pm EDT | -2.5 -110+2.5 -110 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A +2.5 San Francisco 49ers underdog bet wins if they lose by 2 or fewer, tie, or win outright. Your bet loses if they lose by 3 or more.
Favorite Los Angeles Chargers - Los Angeles Chargers bettors risk $100 to win $90.91 at -110 odds.
A -2.5 Los Angeles Chargers favorite bet wins if they win by 3 or more. Your bet loses if they win by 2 or fewer, tie, or lose outright.
Los Angeles Chargers at San Francisco 49ers Prop Bets
| BetMGM Bet |
|
|---|---|
Chargers
49ers
8/23/25 8:30pm EDT | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Preseason Week 3 | Chargers vs 49ers Saturday, August 23rd, 2025 | SF 30, LAC 23 Levi's Stadium | 49ers by 7 |
| 2023 Preseason Week 3 | Chargers vs 49ers Friday, August 25th, 2023 | LAC 23, SF 12 Levi's Stadium | Chargers by 11 |
| 2022 Week 10 | Chargers vs 49ers Sunday, November 13th, 2022 | SF 22, LAC 16 Levi's Stadium | 49ers by 6 |
| 2021 Preseason Week 2 | 49ers vs Chargers Sunday, August 22nd, 2021 | SF 15, LAC 10 SoFi Stadium | 49ers by 5 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Chargers | 0 | 0 | 0 | 0.000 | 0 | 0 | 0-0-0 | 0-0-0 | 0-0-0 | 0.000 | 0-0-0 | 0.000 | 0 | - - |
| San Francisco 49ers | 0 | 0 | 0 | 0.000 | 0 | 0 | 0-0-0 | 0-0-0 | 0-0-0 | 0.000 | 0-0-0 | 0.000 | 0 | - - |
Los Angeles Chargers & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Los Angeles Chargers Futures Odds|
Team | BetMGM |
|---|---|
| Chargers | +2800 Bet |
|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
Los Angeles Chargers & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Los Angeles Chargers vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, August 23rd, 2025 at 8:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Los Angeles Chargers vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Los Angeles Chargers vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other August 23, 2025 NFL Games
- Baltimore Ravens vs Washington Commanders - 8/23/25 12:00pm EDT
- Indianapolis Colts vs Cincinnati Bengals - 8/23/25 1:00pm EDT
- Los Angeles Rams vs Cleveland Browns - 8/23/25 1:06pm EDT
- Houston Texans vs Detroit Lions - 8/23/25 1:07pm EDT
- Denver Broncos vs New Orleans Saints - 8/23/25 1:12pm EDT
- Seattle Seahawks vs Green Bay Packers - 8/23/25 4:00pm EDT
- Jacksonville Jaguars vs Miami Dolphins - 8/23/25 7:00pm EDT
- Buffalo Bills vs Tampa Bay Buccaneers - 8/23/25 7:30pm EDT
- Las Vegas Raiders vs Arizona Cardinals - 8/23/25 10:00pm EDT