New York Giants vs San Francisco 49ers Odds

The Giants will play the 49ers on Thursday, September 21st, 2023. The matchup takes place at Levi's Stadium. Watch this exciting Week 3 matchup at 8:15 pm EDT. Check local listings for coverage on PRIME VIDEO.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

The 2023-24 NFL regular season keeps rolling for the New York Giants and San Francisco 49ers, as they gear up to play an exciting Week 3 matchup at Levi's Stadium. Have a look at the following statistical insights to help you handicap the game.

  • SportsBetting3.com Power Rankings - The New York Giants have started the 2023-24 season with an initial 90.33 power ranking. The San Francisco 49ers currently have a 99.67 power ranking so far.
  • Away New York Giants - Though it's still early in the season, the New York Giants have a 1-0-0 record as an away team, ranking them 2nd in the regular season for away team wins.
  • Home San Francisco 49ers - Looking at the San Francisco 49ers heading into Week 3, they currently have a 0-0-0 record as a home team. They rank 3rd in the regular season for home team wins.
  • Points Scored - The New York Giants currently rank 19th (31) up to Week 3, with the San Francisco 49ers ranked 3rd (60) for points scored in the 2023-24 regular season.
  • Points Against - The New York Giants stand 1st (68) in the early weeks of the regular season for points against. The San Francisco 49ers rank 20th (30) for points against.
  • Team Records - As Week 3 approaches, the New York Giants have a 1-1-0 record, with the San Francisco 49ers at 2-0-0 for the 2023-24 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scurvy dogs! Brace yerselves for a fierce battle on September 21st, 2023... when the New York Giants sail into Levi's Stadium to face the San Francisco 49ers! Arr!

According to the SportsBetting3.com NFL Power Rankings, the Giants be sittin' at a measly 90.33... while them 49ers be boastin' a mighty 99.67! Avast! This be a lopsided clash!

The Giants currently stand at 1-1-0, a mediocre record for a bunch of landlubbers... while them 49ers be struttin' with a flawless 2-0-0 standing. Arr, they be on fire!

Bet this game at BetWay, BetRivers, or BetMGM... but beware, me hearties, for the odds be stacked against the Giants! And if ye want to add some excitement to yer plunderin', review this game's prop bets... a treasure trove of possibilities!

Compare the odds below, if ye dare... but don't be fooled by the Giants' feeble score. The 49ers be a force to be reckoned with, me hearties! Arr! They be the kings of the gridiron!

So gather yer crew and gather yer wits, for this clash be one fer the ages! Will the Giants rise from the depths and shock the 49ers? Or will the 49ers send 'em packin' with their heads hangin'? Only time will tell, me hearties! Anchors aweigh!

Best Giants at 49ers Odds


Best Point Spread Betting Odds
Underdog

New York Giants
Favorite

San Francisco 49ers
The San Francisco 49ers have a -10 -112 point spread at BetRivers Array. They are the point spread favorite in this matchup. The New York Giants have a +10.5 -110 point spread at BetMGM. The New York Giants are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 43.5 points. Risk $109 to win $100. BetMGM has the best under line of 43.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

New York Giants
Favorite

San Francisco 49ers
The San Francisco 49ers are the -530 moneyline favorite. Risk $530 to win $100 on the San Francisco 49ers at BetRivers. The New York Giants are the +425 underdog at BetMGM. Risk $100 to win $425 on the New York Giants. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the New York Giants vs San Francisco 49ers NFL game on Thursday, September 21st, 2023?

The San Francisco 49ers are -10 -112 point spread favorites at BetRivers, while the New York Giants are +10.5 -110 point spread underdogs at BetMGM.

What is the over-under total line for the New York Giants vs San Francisco 49ers NFL game on Thursday, September 21st, 2023?

The best over line is 43.5 -109 points at BetRivers, which means you risk $109 to win $100 betting the over. The best under line is 43.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the New York Giants vs San Francisco 49ers NFL game on Thursday, September 21st, 2023?

The San Francisco 49ers are the -530 moneyline favorite at BetRivers and the New York Giants are the +425 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
49ers
9/21/23 8:15pm EDT
+10.5 -110-10.5 -110
Bet $100 at BetMGM Ohio
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Underdog New York Giants - New York Giants bettors risk $100 to win $90.91 at -110 odds.

A +10.5 New York Giants underdog bet wins if they lose by 10 or fewer, tie, or win outright. Your bet loses if they lose by 11 or more.

Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.

A -10.5 San Francisco 49ers favorite bet wins if they win by 11 or more. Your bet loses if they win by 10 or fewer, tie, or lose outright.

New York Giants at San Francisco 49ers Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Giants
49ers
First Team To Score
9/21/23 8:15pm EDT
+175-225Bet
Giants
49ers
Safety to be Scored
9/21/23 8:15pm EDT
Yes +1000No -3000Bet
Giants
49ers
Game to Overtime
9/21/23 8:15pm EDT
Yes +950No -5000Bet
Giants
Team Total Points
NYG at SF
9/21/23 8:15pm EDT
16.5 o -10516.5 u -120Bet
BetMGM Sports Betting BetMGM
49ers
Team Total Points
NYG at SF
9/21/23 8:15pm EDT
27.5 o +10027.5 u -130Bet
Brock Purdy
Total Passing Yards
NYG at SF
9/21/23 8:15pm EDT
229.5 o -115229.5 u -115Bet
Brock Purdy
Interceptions Thrown
NYG at SF
9/21/23 8:15pm EDT
0.5 o +1700.5 u -225Bet
Brock Purdy
Total Touchdown Passes
NYG at SF
9/21/23 8:15pm EDT
1.5 o -1251.5 u -105Bet
BetMGM Sports Betting BetMGM
Daniel Jones
Interceptions Thrown
NYG at SF
9/21/23 8:15pm EDT
0.5 o -1050.5 u -125Bet
Daniel Jones
Total Touchdown Passes
NYG at SF
9/21/23 8:15pm EDT
1.5 o +1801.5 u -250Bet
Daniel Jones
Total Passing Yards
NYG at SF
9/21/23 8:15pm EDT
216.5 o -115216.5 u -115Bet
Graham Gano
Total Kicking Points
NYG at SF
9/21/23 8:15pm EDT
5.5 o +1005.5 u -135Bet
BetMGM Sports Betting BetMGM
Jake Moody
Total Kicking Points
NYG at SF
9/21/23 8:15pm EDT
7.5 o -1057.5 u -125Bet

Recent Meetings Since 2019

Recent Meetings Since 2019
WeekGameResultMargin
2023
Week 3
Giants vs 49ers
Thursday, September 21st, 2023
SF 30, NYG 12
Levi's Stadium
49ers by 18
2020
Week 3
49ers vs Giants
Sunday, September 27th, 2020
SF 36, NYG 9
MetLife Stadium
49ers by 27

Team Standings

2023-2024 NFL Regular Season Standings - New York Giants, San Francisco 49ers
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz* - San Francisco 49ers12500.7064912985-3-07-2-05-1-00.83310-2-00.8331L3-2-0
New York Giants61100.3532664074-4-02-7-03-3-00.5005-7-00.4171W2-3-0

New York Giants & San Francisco 49ers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

New York Giants Futures Odds
2024-25 New York Giants Super Bowl Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Giants
+15000
Bet
+15000
Bet
San Francisco 49ers Futures Odds
2024-25 San Francisco 49ers Super Bowl Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
49ers
+600
Bet
+550
Bet

New York Giants & San Francisco 49ers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the New York Giants vs San Francisco 49ers NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Thursday, September 21st, 2023 at 8:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the New York Giants vs San Francisco 49ers Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the New York Giants vs San Francisco 49ers Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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