Pittsburgh Steelers vs Buffalo Bills NFL Betting Lines

Odds Preview 288

The Steelers will play the Bills on Sunday, September 12th, 2021. The matchup takes place at Highmark Stadium. Watch this exciting week 1 matchup at 1:00 pm on CBS.

Best Underdog and Favorite Spread Bets
Underdog

Pittsburgh Steelers
Favorite

Buffalo Bills
+6.5 -110 Sb3gen2 -6.5 -105 Sb3gen1
+6.5 -115 Sb3gen1 -6.5 -105 Sb3gen3
+6.5 -115 Sb3gen3 -6.5 -110 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen1 has the best favorite Buffalo Bills spread at -6.5 points. Sb3gen2 has the best underdog Pittsburgh Steelers spread at +6.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
48o -110 Sb3gen3 48u -105 Sb3gen1
48o -115 Sb3gen1 48u -105 Sb3gen2
48o -115 Sb3gen2 48u -110 Sb3gen3
The over under line estimates the combined total of each team's final score. Sb3gen3 has the best over line of 48 points laying $110 to win $100. Sb3gen1 has the best under line of 48 u -105.
Best Money Line Bets
Underdog

Pittsburgh Steelers
Favorite

Buffalo Bills
+230 Sb3gen1 -275 Sb3gen1
+230 Sb3gen3 -275 Sb3gen2
+225 Sb3gen2 -280 Sb3gen3
Here are money lines for the outright winner. Favorite Buffalo Bills has a minus value. Lay $275 at Sb3gen1 to win $100. Underdog Pittsburgh Steelers has a positive value. Risk $100 at Sb3gen1 to win $230.

Pittsburgh Steelers vs Buffalo Bills Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

Pittsburgh Steelers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Pittsburgh Steelers

Cached 2021-09-26 16:01:26
Buffalo Bills Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Buffalo Bills

Cached 2021-09-26 16:01:26

Team Stats

2021 Pittsburgh Steelers Team Stats
Stat Pittsburgh Steelers Opponents
Total 1st Downs 33 44
Total Offensive Yards 583 796
Total Rushing Yards 114 169
Total Passing Yards 469 627
Sacks 5 4
Field Goals 4 / 4 7 / 7
Touchdowns 4 3
Avg Time Of Possession 26:10 33:49
Turnover Ratio

2021 Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 43 29
Total Offensive Yards 685 468
Total Rushing Yards 260 146
Total Passing Yards 425 322
Sacks 8 4
Field Goals 3 / 4 3 / 3
Touchdowns 6 2
Avg Time Of Possession 30:51 29:08
Turnover Ratio


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
Pittsburgh Steelers 1-1-0 0-0-0 1 1 0 0.500 0-1-0 1-0-0 1-1-0
Buffalo Bills 1-1-0 1-0-0 1 1 0 0.500 0-1-0 1-0-0 1-1-0

2021 Pittsburgh Steelers Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
2 Raiders vs
Steelers
LV 26, PIT 17
09/19/2021
3 Bengals vs
Steelers
09/26/2021
1:00PM
4 Steelers vs
Packers
10/03/2021
4:25PM
5 Broncos vs
Steelers
10/10/2021
1:00PM
6 Seahawks vs
Steelers
10/17/2021
8:20PM
7Pittsburgh Steelers ByeN/A
8 Steelers vs
Browns
10/31/2021
1:00PM
9 Bears vs
Steelers
11/08/2021
8:15PM
10 Lions vs
Steelers
11/14/2021
1:00PM
11 Steelers vs
Chargers
11/21/2021
8:20PM
12 Steelers vs
Bengals
11/28/2021
1:00PM
13 Ravens vs
Steelers
12/05/2021
4:25PM
14 Steelers vs
Vikings
12/09/2021
8:20PM
15 Titans vs
Steelers
12/19/2021
1:00PM
16 Steelers vs
Chiefs
12/26/2021
4:25PM
17 Browns vs
Steelers
01/03/2022
8:15PM

2021 Buffalo Bills Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
2 Bills vs
Dolphins
BUF 35, MIA 0
09/19/2021
3 TBD vs
Bills
09/26/2021
1:00PM
4 Texans vs
Bills
10/03/2021
1:00PM
5 Bills vs
Chiefs
10/10/2021
8:20PM
6 Bills vs
Titans
10/18/2021
8:15PM
7Buffalo Bills ByeN/A
8 Dolphins vs
Bills
10/31/2021
1:00PM
9 Bills vs
Jaguars
11/07/2021
1:00PM
10 Bills vs
Jets
11/14/2021
1:00PM
11 Colts vs
Bills
11/21/2021
1:00PM
12 Bills vs
Saints
11/25/2021
8:20PM
13 Patriots vs
Bills
12/06/2021
8:15PM
14 Bills vs
Buccaneers
12/12/2021
4:25PM
15 Panthers vs
Bills
TBD
12/19/2021
16 Bills vs
Patriots
12/26/2021
1:00PM
17 Falcons vs
Bills
01/02/2022
1:00PM

Other 2021 Week 1 Matchups

MatchupDate & Time
Cowboys vs
Buccaneers
TB 31, DAL 29
09/09/2021
Eagles vs
Falcons
PHI 32, ATL 6
09/12/2021
Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
Vikings vs
Bengals
CIN 27, MIN 24 (OT)
09/12/2021
49ers vs
Lions
SF 41, DET 33
09/12/2021
Cardinals vs
Titans
ARI 38, TEN 13
09/12/2021
Seahawks vs
Colts
SEA 28, IND 16
09/12/2021
Chargers vs
TBD
LAC 20, WSH 16
09/12/2021
Jets vs
Panthers
CAR 19, NYJ 14
09/12/2021
Jaguars vs
Texans
HOU 37, JAX 21
09/12/2021
Browns vs
Chiefs
KC 33, CLE 29
09/12/2021
Dolphins vs
Patriots
MIA 17, NE 16
09/12/2021
Packers vs
Saints
NO 38, GB 3
09/12/2021
Broncos vs
Giants
DEN 27, NYG 13
09/12/2021
Bears vs
Rams
LAR 34, CHI 14
09/12/2021
Ravens vs
Raiders
LV 33, BAL 27 (OT)
09/13/2021