San Francisco 49ers vs Los Angeles Chargers NFL Betting Lines

Odds Preview 335

The 49ers will play the Chargers on Sunday, August 22nd, 2021. The matchup takes place at SoFi Stadium. Watch this exciting week PS3 matchup at 7:30 pm.

Best Underdog and Favorite Spread Bets
Underdog

Los Angeles Chargers
Favorite

San Francisco 49ers
+6.5 -110 Sb3gen2 -6 -120 Sb3gen1
+6 +100 Sb3gen1 -6.5 -110 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen1 has the best favorite San Francisco 49ers spread at -6 points. Sb3gen2 has the best underdog Los Angeles Chargers spread at +6.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
34o -110 Sb3gen1 34u -110 Sb3gen1
34o -110 Sb3gen2 34u -110 Sb3gen2
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 34 points laying $110 to win $100. Sb3gen1 has the best under line of 34 u -110.
Best Money Line Bets
Underdog

Los Angeles Chargers
Favorite

San Francisco 49ers
+230 Sb3gen1 -275 Sb3gen1
+230 Sb3gen2 -280 Sb3gen2
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $275 at Sb3gen1 to win $100. Underdog Los Angeles Chargers has a positive value. Risk $100 at Sb3gen1 to win $230.

San Francisco 49ers vs Los Angeles Chargers Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ers

Cached 2022-01-26 17:55:57
Los Angeles Chargers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Los Angeles Chargers

Cached 2022-01-26 17:55:57

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 361 318
Total Offensive Yards 6387 5270
Total Rushing Yards 2166 1760
Total Passing Yards 4221 3510
Sacks 48 33
Field Goals 27 / 32 21 / 27
Touchdowns 50 43
Avg Time Of Possession 31:09 29:47
Turnover Ratio -4

2021 Los Angeles Chargers Team Stats
Stat Los Angeles Chargers Opponents
Total 1st Downs 401 383
Total Offensive Yards 6634 6122
Total Rushing Yards 1834 2361
Total Passing Yards 4800 3761
Sacks 35 31
Field Goals 24 / 27 32 / 35
Touchdowns 58 52
Avg Time Of Possession 29:30 31:09
Turnover Ratio -1


Team Standings

2021 Preseason Season Standings
Team Conf Div W L T Pct Home Road Last 5
San Francisco 49ers
0-0-0 0-0-0 2 1 0 0.667 1-1-0 1-0-0 2-1-0
Los Angeles Chargers
0-0-0 0-0-0 1 2 0 0.333 0-1-0 1-1-0 1-2-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
GB 30, SF 28
09/26/2021
4 Seahawks vs
49ers
SEA 28, SF 21
10/03/2021
5 49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
IND 30, SF 18
10/24/2021
8 49ers vs
Bears
SF 33, CHI 22
10/31/2021
9 Cardinals vs
49ers
ARI 31, SF 17
11/07/2021
10 Rams vs
49ers
SF 31, LAR 10
11/15/2021
11 49ers vs
Jaguars
SF 30, JAX 10
11/21/2021
12 Vikings vs
49ers
SF 34, MIN 26
11/28/2021
13 49ers vs
Seahawks
SEA 30, SF 23
12/05/2021
14 49ers vs
Bengals
SF 26, CIN 23 (OT)
12/12/2021
15 Falcons vs
49ers
SF 31, ATL 13
12/19/2021
16 49ers vs
Titans
TEN 20, SF 17
12/23/2021
17 Texans vs
49ers
SF 23, HOU 7
01/02/2022

2021 Los Angeles Chargers Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Chargers vs
TBD
LAC 20, WSH 16
09/12/2021
2 Cowboys vs
Chargers
DAL 20, LAC 17
09/19/2021
3 Chargers vs
Chiefs
LAC 30, KC 24
09/26/2021
4 Raiders vs
Chargers
LAC 28, LV 14
10/04/2021
5 Browns vs
Chargers
LAC 47, CLE 42
10/10/2021
6 Chargers vs
Ravens
BAL 34, LAC 6
10/17/2021
7Los Angeles Chargers ByeN/A
8 Patriots vs
Chargers
NE 27, LAC 24
10/31/2021
9 Chargers vs
Eagles
LAC 27, PHI 24
11/07/2021
10 Vikings vs
Chargers
MIN 27, LAC 20
11/14/2021
11 Steelers vs
Chargers
LAC 41, PIT 37
11/21/2021
12 Chargers vs
Broncos
DEN 28, LAC 13
11/28/2021
13 Chargers vs
Bengals
LAC 41, CIN 22
12/05/2021
14 Giants vs
Chargers
LAC 37, NYG 21
12/12/2021
15 Chiefs vs
Chargers
KC 34, LAC 28 (OT)
12/16/2021
16 Chargers vs
Texans
HOU 41, LAC 29
12/26/2021
17 Broncos vs
Chargers
LAC 34, DEN 13
01/02/2022

Other 2021 NFL Preseason Matchups

MatchupDate & Time
Patriots vs
Eagles
NE 35, PHI 0
08/19/2021
Bengals vs
TBD
WSH 17, CIN 13
08/20/2021
Chiefs vs
Cardinals
KC 17, ARI 10
08/20/2021
Bills vs
Bears
BUF 41, CHI 15
08/21/2021
Jets vs
Packers
NYJ 23, GB 14
08/21/2021
Falcons vs
Dolphins
MIA 37, ATL 17
08/21/2021
Ravens vs
Panthers
BAL 20, CAR 3
08/21/2021
Lions vs
Steelers
PIT 26, DET 20
08/21/2021
Titans vs
Buccaneers
TEN 34, TB 3
08/21/2021
Texans vs
Cowboys
HOU 20, DAL 14
08/21/2021
Colts vs
Vikings
IND 12, MIN 10
08/21/2021
Raiders vs
Rams
LV 17, LAR 16
08/21/2021
Broncos vs
Seahawks
DEN 30, SEA 3
08/21/2021
Giants vs
Browns
CLE 17, NYG 13
08/22/2021
49ers vs
Chargers
SF 15, LAC 10
08/22/2021
Jaguars vs
Saints
NO 23, JAX 21
08/23/2021