The 49ers will play the Chargers on Sunday, August 22nd, 2021. The matchup takes place at SoFi Stadium. Watch this exciting preseason matchup at 7:30 pm EDT. Check local listings for coverage on NFL NET.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best 49ers at Chargers Odds
| Underdog | Favorite |
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| Over | Under |
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| Underdog | Favorite |
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NFL Odds Example
|
Game |
Bet |
|---|---|
12:51am EDT | TBD OH,US |
No OH,US Point Spread lines available for this game.
San Francisco 49ers at Los Angeles Chargers Prop Bets
 BetMGMBet |
|
|---|---|
49ers
Chargers
8/22/21 7:30pm EDT | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Pre Preseason Week 3 | Chargers vs 49ers Friday, August 25th, 2023 | LAC 23, SF 12 Levi's Stadium | Chargers by 11 |
| 2022 Week 10 | Chargers vs 49ers Sunday, November 13th, 2022 | SF 22, LAC 16 Levi's Stadium | 49ers by 6 |
| 2021 Pre Preseason Week 2 | 49ers vs Chargers Sunday, August 22nd, 2021 | SF 15, LAC 10 SoFi Stadium | 49ers by 5 |
| 2019 Pre Preseason Week 4 | Chargers vs 49ers Thursday, August 29th, 2019 | LAC 27, SF 24 Levi's Stadium | Chargers by 3 |
| 2018 Week 4 | 49ers vs Chargers Sunday, September 30th, 2018 | LAC 29, SF 27 Dignity Health Sports Park | Chargers by 2 |
| 2018 Pre Preseason Week 4 | Chargers vs 49ers Thursday, August 30th, 2018 | LAC 23, SF 21 Levi's Stadium | Chargers by 2 |
| 2017 Pre Preseason Week 4 | Chargers vs 49ers Thursday, August 31st, 2017 | SF 23, LAC 13 Levi's Stadium | 49ers by 10 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - San Francisco 49ers | 10 | 7 | 0 | 0.588 | 427 | 365 | 4-4-0 | 6-3-0 | 2-4-0 | 0.333 | 7-5-0 | 0.583 | 2W | 4-1-0 |
| Los Angeles Chargers | 9 | 8 | 0 | 0.529 | 474 | 459 | 5-4-0 | 4-4-0 | 3-3-0 | 0.500 | 6-6-0 | 0.500 | 1L | 2-3-0 |
San Francisco 49ers & Los Angeles Chargers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| 49ers | +600 Bet | +550 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Chargers | +3000 Bet | +3300 Bet |
San Francisco 49ers & Los Angeles Chargers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Los Angeles Chargers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, August 22nd, 2021 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Los Angeles Chargers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Los Angeles Chargers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other August 22, 2021 NFL Games
| Matchup |
|---|
| New York Giants vs Cleveland Browns |