The 49ers will play the Chargers on Sunday, August 22nd, 2021. The matchup takes place at SoFi Stadium. Watch this exciting preseason matchup at 7:30 pm EDT. Check local listings for coverage on NFL NET.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props. Read the following to understand point spread betting.
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NFL Odds Example
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Game |
Bet |
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6:52pm EST | TBD VA |
VA Odds Pending
No VA Point Spread lines available for this game.
No VA Point Spread lines available for this game.
San Francisco 49ers at Los Angeles Chargers Prop Bets
 BetRiversBet |
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|---|---|
49ers
Chargers
8/22/21 7:30pm EDT | Pending BetRivers |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 10 | Chargers vs 49ers Sunday, November 13th, 2022 | SF 22, LAC 16 Levi's Stadium | 49ers by 6 |
| 2021 Preseason Week 2 | 49ers vs Chargers Sunday, August 22nd, 2021 | SF 15, LAC 10 SoFi Stadium | 49ers by 5 |
| 2019 Preseason Week 4 | Chargers vs 49ers Thursday, August 29th, 2019 | LAC 27, SF 24 Levi's Stadium | Chargers by 3 |
| 2018 Week 4 | 49ers vs Chargers Sunday, September 30th, 2018 | LAC 29, SF 27 Dignity Health Sports Park | Chargers by 2 |
| 2018 Preseason Week 4 | Chargers vs 49ers Thursday, August 30th, 2018 | LAC 23, SF 21 Levi's Stadium | Chargers by 2 |
| 2017 Preseason Week 4 | Chargers vs 49ers Thursday, August 31st, 2017 | SF 23, LAC 13 Levi's Stadium | 49ers by 10 |
Preseason Team Standings
| Team | Conf | Div | W | L | T | Pct | Home | Road | Last 5 |
|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 0-0-0 | 0-0-0 | 2 | 1 | 0 | 0.667 | 1-1-0 | 1-0-0 | 2-1-0 |
| Los Angeles Chargers | 0-0-0 | 0-0-0 | 1 | 2 | 0 | 0.333 | 0-1-0 | 1-1-0 | 1-2-0 |
Team Stats
| Stat | San Francisco 49ers | Opponents |
|---|---|---|
| Total 1st Downs | 361 | 318 |
| Total Offensive Yards | 6337 | 5270 |
| Total Rushing Yards | 2161 | 1760 |
| Total Passing Yards | 4437 | 3510 |
| Sacks | 33 | 48 |
| Field Goals | 27 / 32 | 21 / 27 |
| Touchdowns | 50 | 43 |
| Turnover Ratio | -4 |
| Stat | Los Angeles Chargers | Opponents |
|---|---|---|
| Total 1st Downs | 401 | 383 |
| Total Offensive Yards | 6634 | 6122 |
| Total Rushing Yards | 1834 | 2361 |
| Total Passing Yards | 5014 | 3761 |
| Sacks | 31 | 35 |
| Field Goals | 24 / 27 | 32 / 35 |
| Touchdowns | 57 | 52 |
| Turnover Ratio | 0 |
Team Season Win Totals
The following are each team's season win totals. Learn more about season win totals.
San Francisco 49ers Season Win Total| BetRivers Bet |
|
|---|---|
49ers
2022 Season Win Total |
| BetRivers Bet |
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|---|---|
Chargers
2022 Season Win Total |
Team Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetRivers |
 BetMGM |
|---|---|---|
| 49ers |
No Super Bowl Winner TM Los Angeles Chargers YR: futures available
2021 San Francisco 49ers Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Preseason 1 | Chiefs vs 49ers | KC 19, SF 16 Saturday, August 14th, 2021 |
| Preseason 2 | 49ers vs Chargers | SF 15, LAC 10 Sunday, August 22nd, 2021 |
| Preseason 3 | Raiders vs 49ers | SF 34, LV 10 Sunday, August 29th, 2021 |
| Week 1 | 49ers vs Lions | SF 41, DET 33 Sunday, September 12th, 2021 |
| Week 2 | 49ers vs Eagles | SF 17, PHI 11 Sunday, September 19th, 2021 |
| Week 3 | Packers vs 49ers | GB 30, SF 28 Sunday, September 26th, 2021 |
| Week 4 | Seahawks vs 49ers | SEA 28, SF 21 Sunday, October 3rd, 2021 |
| Week 5 | 49ers vs Cardinals | ARI 17, SF 10 Sunday, October 10th, 2021 |
| Week 6 | 49ers Bye Week | |
| Week 7 | Colts vs 49ers | IND 30, SF 18 Sunday, October 24th, 2021 |
| Week 8 | 49ers vs Bears | SF 33, CHI 22 Sunday, October 31st, 2021 |
| Week 9 | Cardinals vs 49ers | ARI 31, SF 17 Sunday, November 7th, 2021 |
| Week 10 | Rams vs 49ers | SF 31, LAR 10 Monday, November 15th, 2021 |
| Week 11 | 49ers vs Jaguars | SF 30, JAX 10 Sunday, November 21st, 2021 |
| Week 12 | Vikings vs 49ers | SF 34, MIN 26 Sunday, November 28th, 2021 |
| Week 13 | 49ers vs Seahawks | SEA 30, SF 23 Sunday, December 5th, 2021 |
| Week 14 | 49ers vs Bengals | SF 26, CIN 23 (OT) Sunday, December 12th, 2021 |
| Week 15 | Falcons vs 49ers | SF 31, ATL 13 Sunday, December 19th, 2021 |
| Week 16 | 49ers vs Titans | TEN 20, SF 17 Thursday, December 23rd, 2021 |
| Week 17 | Texans vs 49ers | SF 23, HOU 7 Sunday, January 2nd, 2022 |
| Week 18 | 49ers vs Rams | SF 27, LAR 24 (OT) Sunday, January 9th, 2022 |
| Wild Card | 49ers vs Cowboys NFC Wild Card Playoffs | SF 23, DAL 17 Sunday, January 16th, 2022 |
| Divisional Round | 49ers vs Packers NFC Divisional Playoffs | SF 13, GB 10 Saturday, January 22nd, 2022 |
| Conference Championship | 49ers vs Rams NFC Championship | LAR 20, SF 17 Sunday, January 30th, 2022 |
2021 Los Angeles Chargers Games & Results
| Week | Matchup | Date & Time |
|---|---|---|
| Preseason 1 | Chargers vs Rams | LAC 13, LAR 6 Saturday, August 14th, 2021 |
| Preseason 2 | 49ers vs Chargers | SF 15, LAC 10 Sunday, August 22nd, 2021 |
| Preseason 3 | Chargers vs Seahawks | SEA 27, LAC 0 Saturday, August 28th, 2021 |
| Week 1 | Chargers vs TBD | LAC 20, WSH 16 Sunday, September 12th, 2021 |
| Week 2 | Cowboys vs Chargers | DAL 20, LAC 17 Sunday, September 19th, 2021 |
| Week 3 | Chargers vs Chiefs | LAC 30, KC 24 Sunday, September 26th, 2021 |
| Week 4 | Raiders vs Chargers | LAC 28, LV 14 Monday, October 4th, 2021 |
| Week 5 | Browns vs Chargers | LAC 47, CLE 42 Sunday, October 10th, 2021 |
| Week 6 | Chargers vs Ravens | BAL 34, LAC 6 Sunday, October 17th, 2021 |
| Week 7 | Chargers Bye Week | |
| Week 8 | Patriots vs Chargers | NE 27, LAC 24 Sunday, October 31st, 2021 |
| Week 9 | Chargers vs Eagles | LAC 27, PHI 24 Sunday, November 7th, 2021 |
| Week 10 | Vikings vs Chargers | MIN 27, LAC 20 Sunday, November 14th, 2021 |
| Week 11 | Steelers vs Chargers | LAC 41, PIT 37 Sunday, November 21st, 2021 |
| Week 12 | Chargers vs Broncos | DEN 28, LAC 13 Sunday, November 28th, 2021 |
| Week 13 | Chargers vs Bengals | LAC 41, CIN 22 Sunday, December 5th, 2021 |
| Week 14 | Giants vs Chargers | LAC 37, NYG 21 Sunday, December 12th, 2021 |
| Week 15 | Chiefs vs Chargers | KC 34, LAC 28 (OT) Thursday, December 16th, 2021 |
| Week 16 | Chargers vs Texans | HOU 41, LAC 29 Sunday, December 26th, 2021 |
| Week 17 | Broncos vs Chargers | LAC 34, DEN 13 Sunday, January 2nd, 2022 |
| Week 18 | Chargers vs Raiders | LV 35, LAC 32 (OT) Sunday, January 9th, 2022 |
Other August 22, 2021 NFL Games
| Matchup |
|---|
| New York Giants vs Cleveland Browns |