San Francisco 49ers vs Los Angeles Chargers NFL Betting Lines

Odds Preview 335

The 49ers will play the Chargers on Sunday, August 22nd, 2021. The matchup takes place at SoFi Stadium. Watch this exciting week PS3 matchup at 7:30 pm.

Best Underdog and Favorite Spread Bets
Underdog
Los Angeles Chargers
Los Angeles Chargers
Favorite
San Francisco 49ers
San Francisco 49ers
+6.5 -110 Sb3gen2 -6 -120 Sb3gen1
+6 +100 Sb3gen1 -6.5 -110 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Sunday. Sb3gen1 has the best favorite San Francisco 49ers spread at -6 points. Sb3gen2 has the best underdog Los Angeles Chargers spread at +6.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
34o -110 Sb3gen1 34u -110 Sb3gen1
34o -110 Sb3gen2 34u -110 Sb3gen2
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 34 points laying $110 to win $100. Sb3gen1 has the best under line of 34 u -110.
Best Money Line Bets
Underdog
Los Angeles Chargers
Los Angeles Chargers
Favorite
San Francisco 49ers
San Francisco 49ers
+230 Sb3gen1 -275 Sb3gen1
+230 Sb3gen2 -280 Sb3gen2
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $275 at Sb3gen1 to win $100. Underdog Los Angeles Chargers has a positive value. Risk $100 at Sb3gen1 to win $230.

San Francisco 49ers vs Los Angeles Chargers Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ersSan Francisco 49ers

Cached 2021-09-17 02:41:05
Los Angeles Chargers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Los Angeles ChargersLos Angeles Chargers

Cached 2021-09-17 02:41:05

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 21 31
Total Offensive Yards 442 430
Total Rushing Yards 131 116
Total Passing Yards 311 314
Sacks 3 1
Field Goals 2 / 3 1 / 2
Touchdowns 5 4
Avg Time Of Possession 26:33 33:27
Turnover Ratio -1

2021 Los Angeles Chargers Team Stats
Stat Los Angeles Chargers Opponents
Total 1st Downs 27 15
Total Offensive Yards 424 259
Total Rushing Yards 90 126
Total Passing Yards 334 133
Sacks 1 2
Field Goals 2 / 2 3 / 4
Touchdowns 2 1
Avg Time Of Possession 36:03 23:57
Turnover Ratio -1


Team Standings

2021 Preseason Season Standings
Team Conf Div W L T Pct Home Road Last 5
Los Angeles ChargersSan Francisco 49ers 0-0-0 0-0-0 2 1 0 0.667 1-1-0 1-0-0 2-1-0
Los Angeles ChargersLos Angeles Chargers 0-0-0 0-0-0 1 2 0 0.333 0-1-0 1-1-0 1-2-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
09/19/2021
1:00PM
3 Packers vs
49ers
09/26/2021
8:20PM
4 Seahawks vs
49ers
10/03/2021
4:05PM
5 49ers vs
Cardinals
10/10/2021
4:25PM
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
10/24/2021
8:20PM
8 49ers vs
Bears
10/31/2021
1:00PM
9 Cardinals vs
49ers
11/07/2021
4:25PM
10 Rams vs
49ers
11/15/2021
8:15PM
11 49ers vs
Jaguars
11/21/2021
1:00PM
12 Vikings vs
49ers
11/28/2021
4:25PM
13 49ers vs
Seahawks
12/05/2021
8:20PM
14 49ers vs
Bengals
12/12/2021
1:00PM
15 Falcons vs
49ers
12/19/2021
4:05PM
16 49ers vs
Titans
12/23/2021
8:20PM
17 Texans vs
49ers
01/02/2022
4:05PM

2021 Los Angeles Chargers Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Chargers vs
TBD
LAC 20, WSH 16
09/12/2021
2 Cowboys vs
Chargers
09/19/2021
4:25PM
3 Chargers vs
Chiefs
09/26/2021
1:00PM
4 Raiders vs
Chargers
10/04/2021
8:15PM
5 Browns vs
Chargers
10/10/2021
4:05PM
6 Chargers vs
Ravens
10/17/2021
1:00PM
7Los Angeles Chargers ByeN/A
8 Patriots vs
Chargers
10/31/2021
4:05PM
9 Chargers vs
Eagles
11/07/2021
4:05PM
10 Vikings vs
Chargers
11/14/2021
4:05PM
11 Steelers vs
Chargers
11/21/2021
8:20PM
12 Chargers vs
Broncos
11/28/2021
4:05PM
13 Chargers vs
Bengals
12/05/2021
1:00PM
14 Giants vs
Chargers
12/12/2021
4:05PM
15 Chiefs vs
Chargers
12/16/2021
8:20PM
16 Chargers vs
Texans
12/26/2021
1:00PM
17 Broncos vs
Chargers
01/02/2022
4:05PM

Other 2021 NFL Preseason Matchups

MatchupDate & Time
Patriots vs
Eagles
NE 35, PHI 0
08/19/2021
Bengals vs
TBD
WSH 17, CIN 13
08/20/2021
Chiefs vs
Cardinals
KC 17, ARI 10
08/20/2021
Bills vs
Bears
BUF 41, CHI 15
08/21/2021
Jets vs
Packers
NYJ 23, GB 14
08/21/2021
Falcons vs
Dolphins
MIA 37, ATL 17
08/21/2021
Ravens vs
Panthers
BAL 20, CAR 3
08/21/2021
Lions vs
Steelers
PIT 26, DET 20
08/21/2021
Titans vs
Buccaneers
TEN 34, TB 3
08/21/2021
Texans vs
Cowboys
HOU 20, DAL 14
08/21/2021
Colts vs
Vikings
IND 12, MIN 10
08/21/2021
Raiders vs
Rams
LV 17, LAR 16
08/21/2021
Broncos vs
Seahawks
DEN 30, SEA 3
08/21/2021
Giants vs
Browns
CLE 17, NYG 13
08/22/2021
49ers vs
Chargers
SF 15, LAC 10
08/22/2021
Jaguars vs
Saints
NO 23, JAX 21
08/23/2021