San Francisco 49ers vs Los Angeles Rams Odds

The 49ers will play the Rams on Sunday, September 17th, 2023. The matchup takes place at SoFi Stadium. Watch this exciting Week 2 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

It's early in the 2023-24 NFL regular season for the San Francisco 49ers and Los Angeles Rams. Let's review some stats from the 2022 regular season to get an idea of how these teams will fare.

  • SportsBetting3.com Power Rankings - The San Francisco 49ers had a 99.33 power ranking in the 2022 regular season. The power ranking for the Los Angeles Rams in the 2022 regular season was 84.67.
  • Away San Francisco 49ers - At the end of the 2022 regular season, the San Francisco 49ers had a 5-3-0 record as an away team, ranking them 3rd in the regular season for away team wins.
  • Home Los Angeles Rams - The Los Angeles Rams finished the 2022 regular season with a 4-5-0 record as a home team. They ranked 5th for home team wins in the regular season standings.
  • Points Scored - The San Francisco 49ers wound up 6th (450) in the regular season, with the Los Angeles Rams ranked 26th (307) for points scored in the 2022 regular season.
  • Points Against - The San Francisco 49ers finished 27th (277) in the regular season for points against. The Los Angeles Rams wound up 9th (384) in the 2022 regular season for points against.
  • Team Records - The San Francisco 49ers had a 13-4-0 regular season record, with the Los Angeles Rams notching a 5-12-0 regular season standing last year.

Captain Shady Lines

An AI-Powered broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Arrr, ye scurvy dogs! The 49ers be sailin' to SoFi Stadium to face them Rams...

San Francisco be strong last season, while them Rams were a sorry sight...

SportsBetting3.com be yer port for this clash, where ye can bet on this game…

Review the odds below and pick yer treasure wisely, me hearties!

The 49ers be lookin' to continue their success and plunder the Rams' home ground…

While them Rams be yearnin' to bounce back from a wretched season of defeat…

San Francisco, with a record of 13-4-0, be a formidable force to reckon with…

But them Rams, with a dismal 5-12-0 standing, be seekin' redemption on their turf…

SoFi Stadium be the battleground where these rivals be settlin' their grudges…

And ye can bet on this game at SportsBetting3.com, me fellow buccaneers!

Will the 49ers maintain their dominance or will the Rams rise from the depths?

Ye scallywags best keep an eye on the odds and make yer wagers bold!

Visit SportsBetting3.com, review the odds below, and set sail for riches, mateys!

Best 49ers at Rams Odds


Best Point Spread Betting Odds
Underdog

Los Angeles Rams
Favorite

San Francisco 49ers
The San Francisco 49ers have a -7 -115 point spread at BetRivers VA. They are the point spread favorite in this matchup. The Los Angeles Rams have a +7 -105 point spread at BetMGM. The Los Angeles Rams are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 45 points. Risk $110 to win $100. BetRivers has the best under line of 45 points. Risk $109 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Los Angeles Rams
Favorite

San Francisco 49ers
The San Francisco 49ers are the -335 moneyline favorite. Risk $335 to win $100 on the San Francisco 49ers at BetRivers. The Los Angeles Rams are the +275 underdog at BetRivers. Risk $100 to win $275 on the Los Angeles Rams. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the San Francisco 49ers vs Los Angeles Rams NFL game on Sunday, September 17th, 2023?

The San Francisco 49ers are -7 -115 point spread favorites at BetRivers, while the Los Angeles Rams are +7 -105 point spread underdogs at BetMGM.

What is the over-under total line for the San Francisco 49ers vs Los Angeles Rams NFL game on Sunday, September 17th, 2023?

The best over line is 45 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 45 -109 points at BetRivers, and that means you risk $109 to win $100 betting the under.

What is the moneyline for the San Francisco 49ers vs Los Angeles Rams NFL game on Sunday, September 17th, 2023?

The San Francisco 49ers are the -335 moneyline favorite at BetRivers and the Los Angeles Rams are the +275 moneyline underdog at BetRivers.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetRivers Sports Betting BetRivers
Bet
49ers
Rams
9/17/23 4:05pm EDT
Bet $100 at BetRivers Virginia
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Underdog Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $93.46 at -107 odds.

A +7 Los Angeles Rams underdog bet wins if they lose by 6 or fewer, tie, or win outright. The bet pushes if they lose by 7. Your bet loses if they lose by 8 or more.

Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $86.96 at -115 odds.

A -7 San Francisco 49ers favorite bet wins if they win by 8 or more. The bet pushes if they win by 7. Your bet loses if they win by 6 or fewer, tie, or lose outright.

San Francisco 49ers at Los Angeles Rams Prop Bets

NFL Prop Bets
+ Displays more odds
BetRivers Sports Betting BetRivers
Bet
49ers
Rams
First Team To Score
9/17/23 4:05pm EDT
Bet
49ers
Rams
To Score 1st Touchdown
9/17/23 4:05pm EDT
Bet
49ers
Rams
Tie
First to 15 Points
9/17/23 4:05pm EDT
Bet
49ers
Rams
Tie
First to 20 Points
9/17/23 4:05pm EDT
Bet
BetRivers Sports Betting BetRivers
49ers
Rams
Safety to be Scored
9/17/23 4:05pm EDT
Bet
Rams
Team Total Points
SF at LAR
9/17/23 4:05pm EDT
Bet
49ers
Team Total Points
SF at LAR
9/17/23 4:05pm EDT
Bet

Recent Meetings Since 2019

Recent Meetings Since 2019
WeekGameResultMargin
2023
Week 18
Rams vs 49ers
Sunday, January 7th, 2024
LAR 21, SF 20
Levi's Stadium
Rams by 1
2023
Week 2
49ers vs Rams
Sunday, September 17th, 2023
SF 30, LAR 23
SoFi Stadium
49ers by 7
2022
Week 8
49ers vs Rams
Sunday, October 30th, 2022
SF 31, LAR 14
SoFi Stadium
49ers by 17
2022
Week 4
Rams vs 49ers
Monday, October 3rd, 2022
SF 24, LAR 9
Levi's Stadium
49ers by 15
2021
Conference Championship
49ers vs Rams
Sunday, January 30th, 2022
NFC Championship
LAR 20, SF 17
SoFi Stadium
Rams by 3
2021
Week 18
49ers vs Rams
Sunday, January 9th, 2022
SF 27, LAR 24 (OT)
SoFi Stadium
49ers by 3
2021
Week 10
Rams vs 49ers
Monday, November 15th, 2021
SF 31, LAR 10
Levi's Stadium
49ers by 21
2020
Week 12
49ers vs Rams
Sunday, November 29th, 2020
SF 23, LAR 20
SoFi Stadium
49ers by 3
2020
Week 6
Rams vs 49ers
Sunday, October 18th, 2020
SF 24, LAR 16
Levi's Stadium
49ers by 8
2019
Week 16
Rams vs 49ers
Saturday, December 21st, 2019
SF 34, LAR 31
Levi's Stadium
49ers by 3
2019
Week 6
49ers vs Rams
Sunday, October 13th, 2019
SF 20, LAR 7
Los Angeles Memorial Coliseum
49ers by 13

Team Standings

2023-2024 NFL Regular Season Standings - San Francisco 49ers, Los Angeles Rams
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz* - San Francisco 49ers12500.7064912985-3-07-2-05-1-00.83310-2-00.8331L3-2-0
x - Los Angeles Rams10700.5884043775-3-05-4-05-1-00.8338-4-00.6674W4-1-0

San Francisco 49ers & Los Angeles Rams Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds
2023-24 San Francisco 49ers Super Bowl Odds

Team
BetRivers Sports Betting BetRivers
49ers
Los Angeles Rams Futures Odds

No Super Bowl TM Los Angeles Rams YR: futures available

San Francisco 49ers & Los Angeles Rams Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Los Angeles Rams NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 17th, 2023 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Los Angeles Rams Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Los Angeles Rams Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 17, 2023 NFL Games

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