The 49ers will play the Rams on Thursday, October 2nd, 2025. The matchup takes place at SoFi Stadium. Watch this exciting Week 5 matchup at 8:15 pm EDT. Check local listings for coverage on Prime Video.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The San Francisco 49ers and Los Angeles Rams will take the field at SoFi Stadium for a key Week 5 matchup on Thursday, October 2nd, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 5 of the 2025-26 season, the San Francisco 49ers have a power ranking of 93.67. Our calculations have the Los Angeles Rams at a 96.00 power ranking.
- Away San Francisco 49ers - Now in the middle of the season, the San Francisco 49ers have a 2-0-0 record as an away team, ranking them 1st in the league for away team wins.
- Home Los Angeles Rams - The Los Angeles Rams come to this Week 5 matchup with a 2-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
- Points Scored - The San Francisco 49ers currently rank 17th (80) on the edge of Week 5, with the Los Angeles Rams ranked 12th (100) for points scored to date.
- Points Against - The San Francisco 49ers stand 22nd (75) in the middle weeks of the regular season for points against. As for the Los Angeles Rams, they currently rank 19th (81) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 5, the San Francisco 49ers have a 3-1-0 record, with the Los Angeles Rams at 3-1-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scurvy dogs! The San Francisco 49ers be facing off against the Los Angeles Rams in a crucial Week 5 battle on October 2nd, 2025. The Niners be standin' at 3-1-0, while the Rams be matchin' 'em with a 3-1-0 record.
This showdown be happenin' at the grand SoFi Stadium, a sight to behold in the city of angels. The culture o' Los Angeles be vibrant, makin' this game even more excitin'.
According to the SportsBetting3.com NFL Power Rankings, the Rams be holdin' a slight edge with a rankin' of 96.00 compared to the Niners' 93.67. Ye best be ready to bet this game at BetMGM or our preferred sports bettin' partner BetRivers, and look at this game's prop bets. Compare odds from partner sports bettin' sites to maximize yer booty! Arrr!
Best 49ers at Rams Odds
| Underdog San Francisco 49ers | Favorite Los Angeles Rams |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Los Angeles Rams |
|---|---|
Matchup Odds FAQs
The Los Angeles Rams are -8.5 -102 point spread favorites at BetMGM, while the San Francisco 49ers are +8.5 -102 point spread underdogs at BetMGM.
The best over line is 43.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 43.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.
The Los Angeles Rams are the -450 moneyline favorite at BetMGM and the San Francisco 49ers are the +350 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Rams
10/02/25 8:15pm EDT | +8.5 -102-8.5 -102 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $98.04 at -102 odds.
A +8.5 San Francisco 49ers underdog bet wins if they lose by 8 or fewer, tie, or win outright. Your bet loses if they lose by 9 or more.
Favorite Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $98.04 at -102 odds.
A -8.5 Los Angeles Rams favorite bet wins if they win by 9 or more. Your bet loses if they win by 8 or fewer, tie, or lose outright.
San Francisco 49ers at Los Angeles Rams Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Rams
First Team To Score
10/02/25 8:15pm EDT | +145-190Bet |
49ers
Rams
No Touchdown
To Score 1st Touchdown
10/02/25 8:15pm EDT | +180-250+10000Bet |
49ers
Rams
Game to Overtime
10/02/25 8:15pm EDT | Yes +875No -5000Bet |
49ers
Rams
Safety to be Scored
10/02/25 8:15pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
SF at LAR 10/02/25 8:15pm EDT | 0.5 o -1600.5 u +120Bet |
Mac Jones
Interceptions Thrown
SF at LAR 10/02/25 8:15pm EDT | 0.5 o -1550.5 u +120Bet |
Matthew Stafford
Interceptions Thrown
SF at LAR 10/02/25 8:15pm EDT | 0.5 o +1100.5 u -150Bet |
Mac Jones
Longest Passing Completion
SF at LAR 10/02/25 8:15pm EDT | 33.5 o -12533.5 u -105Bet |
| BetMGM | |
Matthew Stafford
Longest Passing Completion
SF at LAR 10/02/25 8:15pm EDT | 35.5 o -12035.5 u -110Bet |
Eddy Pineiro
Total Kicking Points
SF at LAR 10/02/25 8:15pm EDT | 6.5 o -1206.5 u -110Bet |
Joshua Karty
Total Kicking Points
SF at LAR 10/02/25 8:15pm EDT | 7.5 o -1507.5 u +115Bet |
Brock Purdy
Total Pass Completions
SF at LAR 10/02/25 8:15pm EDT | 21.5 o -12521.5 u -105Bet |
| BetMGM | |
Mac Jones
Total Pass Completions
SF at LAR 10/02/25 8:15pm EDT | 21.5 o -10521.5 u -130Bet |
Matthew Stafford
Total Pass Completions
SF at LAR 10/02/25 8:15pm EDT | 21.5 o -13021.5 u -105Bet |
Brock Purdy
Total Passing Yards
SF at LAR 10/02/25 8:15pm EDT | 237.5 o -115237.5 u -115Bet |
Mac Jones
Total Passing Yards
SF at LAR 10/02/25 8:15pm EDT | 220.5 o -115220.5 u -115Bet |
| BetMGM | |
Matthew Stafford
Total Passing Yards
SF at LAR 10/02/25 8:15pm EDT | 238.5 o -115238.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
SF at LAR 10/02/25 8:15pm EDT | 1.5 o +1101.5 u -150Bet |
Mac Jones
Total Touchdown Passes
SF at LAR 10/02/25 8:15pm EDT | 1.5 o +1651.5 u -220Bet |
Matthew Stafford
Total Touchdown Passes
SF at LAR 10/02/25 8:15pm EDT | 1.5 o -1851.5 u +135Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 5 | 49ers vs Rams Thursday, October 2nd, 2025 | SF 26, LAR 23 (OT) SoFi Stadium | 49ers by 3 |
| 2024 Week 15 | Rams vs 49ers Thursday, December 12th, 2024 | LAR 12, SF 6 Levi's Stadium | Rams by 6 |
| 2024 Week 3 | 49ers vs Rams Sunday, September 22nd, 2024 | LAR 27, SF 24 SoFi Stadium | Rams by 3 |
| 2023 Week 18 | Rams vs 49ers Sunday, January 7th, 2024 | LAR 21, SF 20 Levi's Stadium | Rams by 1 |
| 2023 Week 2 | 49ers vs Rams Sunday, September 17th, 2023 | SF 30, LAR 23 SoFi Stadium | 49ers by 7 |
| 2022 Week 8 | 49ers vs Rams Sunday, October 30th, 2022 | SF 31, LAR 14 SoFi Stadium | 49ers by 17 |
| 2022 Week 4 | Rams vs 49ers Monday, October 3rd, 2022 | SF 24, LAR 9 Levi's Stadium | 49ers by 15 |
| 2021 Conference Championship | 49ers vs Rams Sunday, January 30th, 2022 NFC Championship | LAR 20, SF 17 SoFi Stadium | Rams by 3 |
| 2021 Week 18 | 49ers vs Rams Sunday, January 9th, 2022 | SF 27, LAR 24 (OT) SoFi Stadium | 49ers by 3 |
| 2021 Week 10 | Rams vs 49ers Monday, November 15th, 2021 | SF 31, LAR 10 Levi's Stadium | 49ers by 21 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Rams | 5 | 2 | 0 | 0.714 | 175 | 117 | 2-1-0 | 3-1-0 | 0-1-0 | 0.000 | 0-2-0 | 0.000 | 2W | 3-2-0 |
| San Francisco 49ers | 5 | 3 | 0 | 0.625 | 160 | 164 | 2-1-0 | 3-2-0 | 3-0-0 | 1.000 | 5-1-0 | 0.833 | 1L | 2-3-0 |
San Francisco 49ers & Los Angeles Rams Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
|
Team | BetMGM |
|---|---|
| Rams | +1100 Bet |
San Francisco 49ers & Los Angeles Rams Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Los Angeles Rams NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, October 2nd, 2025 at 8:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Los Angeles Rams Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Los Angeles Rams Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.