San Francisco 49ers vs Tennessee Titans NFL Betting Lines

Odds Preview 561

The 49ers will play the Titans on Thursday, December 23rd, 2021. The matchup takes place at Nissan Stadium. Watch this exciting week 16 matchup at 8:20 pm on NFL NET.

Best Underdog and Favorite Spread Bets
Underdog

Tennessee Titans
Favorite

San Francisco 49ers
+3.5 -110 Sb3gen1 -3.5 -105 Sb3gen3
+3.5 -110 Sb3gen2 -3.5 -110 Sb3gen1
+3.5 -115 Sb3gen3 -3.5 -110 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Thursday. Sb3gen3 has the best favorite San Francisco 49ers spread at -3.5 points. Sb3gen1 has the best underdog Tennessee Titans spread at +3.5 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
44.5o -110 Sb3gen3 45.5u -105 Sb3gen1
45o -110 Sb3gen2 45u -110 Sb3gen2
45.5o -115 Sb3gen1 44.5u -110 Sb3gen3
The over under line estimates the combined total of each team's final score. Sb3gen3 has the best over line of 44.5 points laying $110 to win $100. Sb3gen1 has the best under line of 45.5 u -105.
Best Money Line Bets
Underdog

Tennessee Titans
Favorite

San Francisco 49ers
+165 Sb3gen2 -180 Sb3gen1
+160 Sb3gen1 -185 Sb3gen3
+155 Sb3gen3 -195 Sb3gen2
Here are money lines for the outright winner. Favorite San Francisco 49ers has a minus value. Lay $180 at Sb3gen1 to win $100. Underdog Tennessee Titans has a positive value. Risk $100 at Sb3gen2 to win $165.

San Francisco 49ers vs Tennessee Titans Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

San Francisco 49ers Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
San Francisco 49ers

Cached 2022-01-23 15:44:43
Tennessee Titans Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Tennessee Titans

Cached 2022-01-23 15:44:43

Team Stats

2021 San Francisco 49ers Team Stats
Stat San Francisco 49ers Opponents
Total 1st Downs 361 318
Total Offensive Yards 6387 5270
Total Rushing Yards 2166 1760
Total Passing Yards 4221 3510
Sacks 48 33
Field Goals 27 / 32 21 / 27
Touchdowns 50 43
Avg Time Of Possession 31:09 29:47
Turnover Ratio -4

2021 Tennessee Titans Team Stats
Stat Tennessee Titans Opponents
Total 1st Downs 362 331
Total Offensive Yards 5822 5607
Total Rushing Yards 2404 1438
Total Passing Yards 3418 4169
Sacks 43 47
Field Goals 26 / 32 31 / 38
Touchdowns 49 38
Avg Time Of Possession 33:20 27:53
Turnover Ratio -3


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
xy
San Francisco 49ers
7-5-0 2-4-0 10 7 0 0.588 4-4-0 6-3-0 4-1-0
xz*
Tennessee Titans
8-4-0 5-1-0 12 5 0 0.706 7-2-0 5-3-0 4-1-0

2021 San Francisco 49ers Games & Results

Bye Week: 6
WeekMatchupDate & Time
1 49ers vs
Lions
SF 41, DET 33
09/12/2021
2 49ers vs
Eagles
SF 17, PHI 11
09/19/2021
3 Packers vs
49ers
GB 30, SF 28
09/26/2021
4 Seahawks vs
49ers
SEA 28, SF 21
10/03/2021
5 49ers vs
Cardinals
ARI 17, SF 10
10/10/2021
6San Francisco 49ers ByeN/A
7 Colts vs
49ers
IND 30, SF 18
10/24/2021
8 49ers vs
Bears
SF 33, CHI 22
10/31/2021
9 Cardinals vs
49ers
ARI 31, SF 17
11/07/2021
10 Rams vs
49ers
SF 31, LAR 10
11/15/2021
11 49ers vs
Jaguars
SF 30, JAX 10
11/21/2021
12 Vikings vs
49ers
SF 34, MIN 26
11/28/2021
13 49ers vs
Seahawks
SEA 30, SF 23
12/05/2021
14 49ers vs
Bengals
SF 26, CIN 23 (OT)
12/12/2021
15 Falcons vs
49ers
SF 31, ATL 13
12/19/2021
16 49ers vs
Titans
TEN 20, SF 17
12/23/2021
17 Texans vs
49ers
SF 23, HOU 7
01/02/2022

2021 Tennessee Titans Games & Results

Bye Week: 13
WeekMatchupDate & Time
1 Cardinals vs
Titans
ARI 38, TEN 13
09/12/2021
2 Titans vs
Seahawks
TEN 33, SEA 30 (OT)
09/19/2021
3 Colts vs
Titans
TEN 25, IND 16
09/26/2021
4 Titans vs
Jets
NYJ 27, TEN 24 (OT)
10/03/2021
5 Titans vs
Jaguars
TEN 37, JAX 19
10/10/2021
6 Bills vs
Titans
TEN 34, BUF 31
10/18/2021
7 Chiefs vs
Titans
TEN 27, KC 3
10/24/2021
8 Titans vs
Colts
TEN 34, IND 31 (OT)
10/31/2021
9 Titans vs
Rams
TEN 28, LAR 16
11/07/2021
10 Saints vs
Titans
TEN 23, NO 21
11/14/2021
11 Texans vs
Titans
HOU 22, TEN 13
11/21/2021
12 Titans vs
Patriots
NE 36, TEN 13
11/28/2021
13Tennessee Titans ByeN/A
14 Jaguars vs
Titans
TEN 20, JAX 0
12/12/2021
15 Titans vs
Steelers
PIT 19, TEN 13
12/19/2021
16 49ers vs
Titans
TEN 20, SF 17
12/23/2021
17 Dolphins vs
Titans
TEN 34, MIA 3
01/02/2022

Other 2021 Week 16 Matchups

MatchupDate & Time
49ers vs
Titans
TEN 20, SF 17
12/23/2021
Browns vs
Packers
GB 24, CLE 22
12/25/2021
Colts vs
Cardinals
IND 22, ARI 16
12/25/2021
Lions vs
Falcons
ATL 20, DET 16
12/26/2021
Ravens vs
Bengals
CIN 41, BAL 21
12/26/2021
Rams vs
Vikings
LAR 30, MIN 23
12/26/2021
Bills vs
Patriots
BUF 33, NE 21
12/26/2021
Jaguars vs
Jets
NYJ 26, JAX 21
12/26/2021
Giants vs
Eagles
PHI 34, NYG 10
12/26/2021
Buccaneers vs
Panthers
TB 32, CAR 6
12/26/2021
Chargers vs
Texans
HOU 41, LAC 29
12/26/2021
Bears vs
Seahawks
CHI 25, SEA 24
12/26/2021
Steelers vs
Chiefs
KC 36, PIT 10
12/26/2021
Broncos vs
Raiders
LV 17, DEN 13
12/26/2021
TBD vs
Cowboys
DAL 56, WSH 14
12/26/2021
Dolphins vs
Saints
MIA 20, NO 3
12/27/2021