The Titans will play the 49ers on Sunday, December 14th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 15 matchup at 4:25 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 15, as the 2025-26 NFL regular season is coming to a close. This week's action includes a matchup between the Tennessee Titans and San Francisco 49ers. They'll play on Sunday, December 14th, 2025 at Levi's Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 15 of the 2025-26 NFL regular season, the Tennessee Titans have a 84.67 power ranking based on our formula. Their opponent, the San Francisco 49ers, currently possess a 94.67 power ranking.
- Away Tennessee Titans - With the season coming to a close, the Tennessee Titans have a 2-4-0 record as an away team, ranking them 5th in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers come to this Week 15 game with a 3-2-0 record as a home team. They rank 4th in the league for home team wins as the 2025-26 regular season wraps up.
- Points Scored - The Tennessee Titans currently rank 29th (201) headed into Week 15, with the San Francisco 49ers ranked 14th (307) for points scored to date.
- Points Against - As the regular season winds down, the Tennessee Titans rank 4th (357) for points score against them. Note that the San Francisco 49ers now rank 23rd (269) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 15, the Tennessee Titans have a 2-11-0 record, with the San Francisco 49ers at 9-4-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye, mateys! The Tennessee Titans be facing the San Francisco 49ers on Sunday. This game be crucial as the NFL regular season be nearin' its end.
The Tennessee Titans be strugglin' with a 2-11-0 record, while the San Francisco 49ers be sittin' pretty at 9-4-0. The Titans be lookin' to make a mark in the AFC South Division.
This Week 15 showdown be happenin' at Levi's Stadium. SportsBetting3.com Power Rankings favor the 49ers over the Titans. Place a bet at BetRivers or BetMGM and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks, so get ready for a clash on the gridiron!
Best Titans at 49ers Odds
| Underdog Tennessee Titans | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Tennessee Titans | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -12.5 -110 point spread favorites at BetMGM, while the Tennessee Titans are +12.5 -110 point spread underdogs at BetMGM.
The best over line is 44.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 44.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -900 moneyline favorite at BetMGM and the Tennessee Titans are the +600 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Titans
49ers
4:25pm EST | +12.5 -110-12.5 -110 |
Underdog Tennessee Titans - Tennessee Titans bettors risk $100 to win $90.91 at -110 odds.
A +12.5 Tennessee Titans underdog bet wins if they lose by 12 or fewer, tie, or win outright. Your bet loses if they lose by 13 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A -12.5 San Francisco 49ers favorite bet wins if they win by 13 or more. Your bet loses if they win by 12 or fewer, tie, or lose outright.
Tennessee Titans at San Francisco 49ers Prop Bets
| BetMGM Bet |
|
|---|---|
Titans
49ers
First Team To Score
4:25pm EST | +160-210Bet |
Titans
49ers
No Touchdown
To Score 1st Touchdown
4:25pm EST | +225-350+10000Bet |
Titans
49ers
Game to Overtime
4:25pm EST | Yes +1050No -10000Bet |
Titans
49ers
Safety to be Scored
4:25pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
TEN at SF 4:25pm EST | 0.5 o -1150.5 u -115Bet |
Cam Ward
Interceptions Thrown
TEN at SF 4:25pm EST | 0.5 o -1050.5 u -125Bet |
Brock Purdy
Longest Passing Completion
TEN at SF 4:25pm EST | 35.5 o -11535.5 u -115Bet |
Cam Ward
Longest Passing Completion
TEN at SF 4:25pm EST | 30.5 o -11830.5 u -115Bet |
| BetMGM | |
Eddy Pineiro
Total Kicking Points
TEN at SF 4:25pm EST | 7.5 o -1357.5 u +100Bet |
Joey Slye
Total Kicking Points
TEN at SF 4:25pm EST | 5.5 o +1005.5 u -130Bet |
Brock Purdy
Total Pass Completions
TEN at SF 4:25pm EST | 21.5 o -11021.5 u -120Bet |
Cam Ward
Total Pass Completions
TEN at SF 4:25pm EST | 21.5 o +10021.5 u -135Bet |
| BetMGM | |
Brock Purdy
Total Passing Yards
TEN at SF 4:25pm EST | 242.5 o -115242.5 u -115Bet |
Cam Ward
Total Passing Yards
TEN at SF 4:25pm EST | 199.5 o -115199.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
TEN at SF 4:25pm EST | 1.5 o -1651.5 u +125Bet |
Cam Ward
Total Touchdown Passes
TEN at SF 4:25pm EST | 1.5 o +1951.5 u -275Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Preseason Week 1 | 49ers vs Titans Saturday, August 10th, 2024 | TEN 17, SF 13 Nissan Stadium | Titans by 4 |
| 2021 Week 16 | 49ers vs Titans Thursday, December 23rd, 2021 | TEN 20, SF 17 Nissan Stadium | Titans by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 9 | 4 | 0 | 0.692 | 307 | 269 | 3-2-0 | 6-2-0 | 4-1-0 | 0.800 | 8-2-0 | 0.800 | 3W | 4-1-0 |
| Tennessee Titans | 2 | 11 | 0 | 0.154 | 201 | 357 | 0-7-0 | 2-4-0 | 0-5-0 | 0.000 | 1-9-0 | 0.100 | 1W | 1-4-0 |
Tennessee Titans & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Tennessee Titans Futures OddsNo Super Bowl TM Tennessee Titans YR: futures available
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2200 Bet |
Tennessee Titans & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Tennessee Titans vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 14th, 2025 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Tennessee Titans vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Tennessee Titans vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 14, 2025 NFL Games
- Baltimore Ravens vs Cincinnati Bengals - 1:00pm EST
- Las Vegas Raiders vs Philadelphia Eagles - 1:00pm EST
- Los Angeles Chargers vs Kansas City Chiefs - 1:00pm EST
- New York Jets vs Jacksonville Jaguars - 1:00pm EST
- Arizona Cardinals vs Houston Texans - 1:00pm EST
- Cleveland Browns vs Chicago Bears - 1:00pm EST
- Washington Commanders vs New York Giants - 1:00pm EST
- Buffalo Bills vs New England Patriots - 1:00pm EST
- Green Bay Packers vs Denver Broncos - 4:25pm EST
- Detroit Lions vs Los Angeles Rams - 4:25pm EST
- Carolina Panthers vs New Orleans Saints - 4:25pm EST
- Indianapolis Colts vs Seattle Seahawks - 4:25pm EST
- Minnesota Vikings vs Dallas Cowboys - 8:20pm EST