The Rams will play the 49ers on Sunday, November 9th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 10 matchup at 4:25 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
Rolling into Week 10, the Los Angeles Rams and San Francisco 49ers will matchup on Sunday, November 9th, 2025 at Levi's Stadium for an important mid-season game. We've compiled some key performance stats below to help you handicap this matchup. Now that the 2025-26 NFL regular season is half over, teams need to sharpen their performance with an eye for the January playoffs.
- SportsBetting3.com Power Rankings - As of Week 10 of the 2025-26 season, the Los Angeles Rams have a power ranking of 99.00. Our formula has the San Francisco 49ers at a 94.00 power ranking.
- Away Los Angeles Rams - With the season now half over, the Los Angeles Rams have a 3-1-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers start this Week 10 matchup with a 2-1-0 record as a home team. They rank 4th in the league for home team wins so far in the 2025-26 regular season.
- Points Scored - The Los Angeles Rams currently rank 10th (209) looking at Week 10, with the San Francisco 49ers ranked 16th (194) for points scored to date.
- Points Against - The Los Angeles Rams stand 26th (127) now halfway through the regular season for points against. Meanwhile the San Francisco 49ers currently rank 14th (188) for points against.
- Team Records - The second half of the season is make or break. Heading into Week 10, the Los Angeles Rams have a 6-2-0 record, with the San Francisco 49ers at 6-3-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Rams be playin' the 49ers in a crucial Week 10 showdown.
The season be half done, and both teams be lookin' to secure playoff spots.
The battle be happenin' at Levi's Stadium, a fine place with a rich culture.
The Rams be favored with a Power Rankings of 99.00, but the 49ers be close behind at 94.00.
I recommend betting on this game at BetRivers, or BetMGM. Review this matchup's prop bets below, and look at the odds from our partner sportsbooks. Arrr!
Best Rams at 49ers Odds
| Underdog San Francisco 49ers | Favorite Los Angeles Rams |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Los Angeles Rams |
|---|---|
Matchup Odds FAQs
The Los Angeles Rams are -6 -110 point spread favorites at BetMGM, while the San Francisco 49ers are +6 -110 point spread underdogs at BetMGM.
The best over line is 49.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 49.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Los Angeles Rams are the -250 moneyline favorite at BetMGM and the San Francisco 49ers are the +200 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Rams
49ers
11/09/25 4:25pm EST | -6 -110+6 -110 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A +6 San Francisco 49ers underdog bet wins if they lose by 5 or fewer, tie, or win outright. The bet pushes if they lose by 6. Your bet loses if they lose by 7 or more.
Favorite Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $90.91 at -110 odds.
A -6 Los Angeles Rams favorite bet wins if they win by 7 or more. The bet pushes if they win by 6. Your bet loses if they win by 5 or fewer, tie, or lose outright.
Los Angeles Rams at San Francisco 49ers Prop Bets
| BetMGM Bet |
|
|---|---|
Rams
49ers
First Team To Score
11/09/25 4:25pm EST | -145+110Bet |
Rams
49ers
No Touchdown
To Score 1st Touchdown
11/09/25 4:25pm EST | -160+120+10000Bet |
Rams
49ers
Game to Overtime
11/09/25 4:25pm EST | Yes +775No -2500Bet |
Rams
49ers
Safety to be Scored
11/09/25 4:25pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Mac Jones
Interceptions Thrown
LAR at SF 11/09/25 4:25pm EST | 0.5 o -1400.5 u +105Bet |
Matthew Stafford
Interceptions Thrown
LAR at SF 11/09/25 4:25pm EST | 0.5 o +1050.5 u -140Bet |
Mac Jones
Longest Passing Completion
LAR at SF 11/09/25 4:25pm EST | 35.5 o -12035.5 u -110Bet |
Matthew Stafford
Longest Passing Completion
LAR at SF 11/09/25 4:25pm EST | 38.5 o -11038.5 u -120Bet |
| BetMGM | |
Eddy Pineiro
Total Kicking Points
LAR at SF 11/09/25 4:25pm EST | 6.5 o -1256.5 u -105Bet |
Mac Jones
Total Pass Completions
LAR at SF 11/09/25 4:25pm EST | 23.5 o +10023.5 u -135Bet |
Matthew Stafford
Total Pass Completions
LAR at SF 11/09/25 4:25pm EST | 23.5 o -13523.5 u +100Bet |
Mac Jones
Total Passing Yards
LAR at SF 11/09/25 4:25pm EST | 255.5 o -115255.5 u -115Bet |
| BetMGM | |
Matthew Stafford
Total Passing Yards
LAR at SF 11/09/25 4:25pm EST | 269.5 o -115269.5 u -115Bet |
Mac Jones
Total Touchdown Passes
LAR at SF 11/09/25 4:25pm EST | 1.5 o -1201.5 u -110Bet |
Matthew Stafford
Total Touchdown Passes
LAR at SF 11/09/25 4:25pm EST | 2.5 o +1552.5 u -210Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 10 | Rams vs 49ers Sunday, November 9th, 2025 | LAR 42, SF 26 Levi's Stadium | Rams by 16 |
| 2025 Week 5 | 49ers vs Rams Thursday, October 2nd, 2025 | SF 26, LAR 23 (OT) SoFi Stadium | 49ers by 3 |
| 2024 Week 15 | Rams vs 49ers Thursday, December 12th, 2024 | LAR 12, SF 6 Levi's Stadium | Rams by 6 |
| 2024 Week 3 | 49ers vs Rams Sunday, September 22nd, 2024 | LAR 27, SF 24 SoFi Stadium | Rams by 3 |
| 2023 Week 18 | Rams vs 49ers Sunday, January 7th, 2024 | LAR 21, SF 20 Levi's Stadium | Rams by 1 |
| 2023 Week 2 | 49ers vs Rams Sunday, September 17th, 2023 | SF 30, LAR 23 SoFi Stadium | 49ers by 7 |
| 2022 Week 8 | 49ers vs Rams Sunday, October 30th, 2022 | SF 31, LAR 14 SoFi Stadium | 49ers by 17 |
| 2022 Week 4 | Rams vs 49ers Monday, October 3rd, 2022 | SF 24, LAR 9 Levi's Stadium | 49ers by 15 |
| 2021 Conference Championship | 49ers vs Rams Sunday, January 30th, 2022 NFC Championship | LAR 20, SF 17 SoFi Stadium | Rams by 3 |
| 2021 Week 18 | 49ers vs Rams Sunday, January 9th, 2022 | SF 27, LAR 24 (OT) SoFi Stadium | 49ers by 3 |
| 2021 Week 10 | Rams vs 49ers Monday, November 15th, 2021 | SF 31, LAR 10 Levi's Stadium | 49ers by 21 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Los Angeles Rams | 9 | 2 | 0 | 0.818 | 306 | 179 | 5-1-0 | 4-1-0 | 2-1-0 | 0.667 | 4-2-0 | 0.667 | 6W | 5-0-0 |
| San Francisco 49ers | 8 | 4 | 0 | 0.667 | 281 | 261 | 3-2-0 | 5-2-0 | 4-1-0 | 0.800 | 8-2-0 | 0.800 | 2W | 3-2-0 |
Los Angeles Rams & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Los Angeles Rams Futures Odds|
Team | BetMGM |
|---|---|
| Rams | +400 Bet |
|
Team | BetMGM |
|---|---|
| 49ers | +3000 Bet |
Los Angeles Rams & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Los Angeles Rams vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, November 9th, 2025 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Los Angeles Rams vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Los Angeles Rams vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 9, 2025 NFL Games
- Atlanta Falcons vs Indianapolis Colts - 11/09/25 9:30am EST
- Buffalo Bills vs Miami Dolphins - 11/09/25 1:00pm EST
- New England Patriots vs Tampa Bay Buccaneers - 11/09/25 1:00pm EST
- Cleveland Browns vs New York Jets - 11/09/25 1:00pm EST
- New York Giants vs Chicago Bears - 11/09/25 1:00pm EST
- New Orleans Saints vs Carolina Panthers - 11/09/25 1:00pm EST
- Jacksonville Jaguars vs Houston Texans - 11/09/25 1:00pm EST
- Baltimore Ravens vs Minnesota Vikings - 11/09/25 1:03pm EST
- Arizona Cardinals vs Seattle Seahawks - 11/09/25 4:05pm EST
- Detroit Lions vs Washington Commanders - 11/09/25 4:25pm EST
- Pittsburgh Steelers vs Los Angeles Chargers - 11/09/25 8:20pm EST