The Diamondbacks will play the Giants on Wednesday, September 10th, 2025. Your timezone's first pitch time is 3:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Diamondbacks at Giants Odds
| Underdog Arizona Diamondbacks | Favorite San Francisco Giants |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco Giants | Favorite Arizona Diamondbacks |
|---|---|
Matchup Odds FAQs
The San Francisco Giants are the -120 moneyline favorite at BetMGM and the Arizona Diamondbacks are the +100 moneyline underdog at BetMGM.
The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.
The Arizona Diamondbacks are -1.5 +165 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -200 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Diamondbacks
Giants
9/10/25 3:45pm EDT | +100-120 |
- Arizona Diamondbacks bettors risk $100 to win $100 at +100 odds. The implied probability for Arizona Diamondbacks is 50%.
- San Francisco Giants bettors risk $100 to win $83.33 at -120 odds. The implied probability for San Francisco Giants is 54.55%.
Arizona Diamondbacks at San Francisco Giants Prop Bets
| BetMGM Bet |
|
|---|---|
Diamondbacks
Giants
First Team to Score
9/10/25 3:45pm EDT | -160+125Bet |
Diamondbacks
Giants
Tie
1st Inning Winner
9/10/25 3:45pm EDT | +280+290-130Bet |
Diamondbacks
Giants
Tie
First 3 Innings Winner
9/10/25 3:45pm EDT | +140+140+300Bet |
Diamondbacks
Giants
To Extra Innings
9/10/25 3:45pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Diamondbacks
Giants
1st Team to Score Will Win
9/10/25 3:45pm EDT | Yes -250No +190Bet |
Diamondbacks
Total Runs
ARI at SFO 9/10/25 3:45pm EDT | 4.5 o +1154.5 u -150Bet |
Giants
Total Runs
ARI at SFO 9/10/25 3:45pm EDT | 4.5 o +1104.5 u -145Bet |
Carson Seymour
Strikeouts Thrown
ARI at SFO 9/10/25 3:45pm EDT | 4.5 o +1304.5 u -165Bet |
| BetMGM | |
Eduardo Rodriguez
Strikeouts Thrown
ARI at SFO 9/10/25 3:45pm EDT | 4.5 o -1104.5 u -118Bet |
Arizona Diamondbacks & San Francisco Giants Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Arizona Diamondbacks World Series Odds|
Team | BetMGM |
|---|---|
| Diamondbacks |
|
Team | BetMGM |
|---|---|
| Giants |
Arizona Diamondbacks & San Francisco Giants Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - San Francisco Giants | 81 | 81 | 0.500 | +16.0 | 42-39 | 39-42 | 705 | 684 | +21 | W4 | 5-5 |
| e - Arizona Diamondbacks | 80 | 82 | 0.494 | +17.0 | 43-38 | 37-44 | 791 | 785 | +6 | L5 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Arizona Diamondbacks vs San Francisco Giants MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 10th, 2025 at 3:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Arizona Diamondbacks vs San Francisco Giants Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Arizona Diamondbacks vs San Francisco Giants Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 10, 2025 MLB Games
- Milwaukee Brewers vs Texas Rangers
- Boston Red Sox vs Oakland Athletics
- Minnesota Twins vs Los Angeles Angels
- Pittsburgh Pirates vs Baltimore Orioles
- Kansas City Royals vs Cleveland Guardians
- Washington Nationals vs Miami Marlins
- New York Mets vs Philadelphia Phillies
- Detroit Tigers vs New York Yankees
- Houston Astros vs Toronto Blue Jays
- Chicago Cubs vs Atlanta Braves
- Tampa Bay Rays vs Chicago White Sox
- Cincinnati Reds vs San Diego Padres
- St. Louis Cardinals vs Seattle Mariners
- Colorado Rockies vs Los Angeles Dodgers