New York Yankees vs Baltimore Orioles Odds

The Yankees will play the Orioles on Sunday, September 21st, 2025. Your timezone's first pitch time is 1:35 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Yankees at Orioles Odds

**Best Moneyline Betting Odds**
Underdog Baltimore Orioles	Favorite New York Yankees
+115 BetMGM Bet	-135 BetMGM Bet

The New York Yankees are the -135 moneyline favorite. Risk $135 to win $100 on the New York Yankees at BetMGM. The Baltimore Orioles are the +115 underdog at BetMGM. Risk $100 to win $115 on the Baltimore Orioles. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8.5 o -110 BetMGM Bet	8.5 u -110 BetMGM Bet

BetMGM has the best over line of 8.5 runs. Risk $110 to win $100. BetMGM has the best under line of 8.5 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Baltimore Orioles	Favorite New York Yankees
+1.5 -145 BetMGM Bet	-1.5 +118 BetMGM Bet

The New York Yankees have a -1.5 +118 run line at BetMGM OH. They are the run line favorite in this matchup. The Baltimore Orioles have a +1.5 -145 run line at BetMGM OH. The Baltimore Orioles are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the New York Yankees vs Baltimore Orioles MLB game on Sunday, September 21st, 2025?

The New York Yankees are the -135 moneyline favorite at BetMGM and the Baltimore Orioles are the +115 moneyline underdog at BetMGM.

What is the over-under total line for the New York Yankees vs Baltimore Orioles MLB game on Sunday, September 21st, 2025?

The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the New York Yankees vs Baltimore Orioles MLB game on Sunday, September 21st, 2025?

The New York Yankees are -1.5 +118 run line favorites at BetMGM, while the Baltimore Orioles are +1.5 -145 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Yankees Orioles 9/21/25 1:35pm EDT	-135 +115

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Possible Moneyline Outcomes

Baltimore Orioles bettors risk $100 to win $115 at +115 odds. The implied probability for Baltimore Orioles is 46.51%.
New York Yankees bettors risk $100 to win $74.07 at -135 odds. The implied probability for New York Yankees is 57.45%.

New York Yankees at Baltimore Orioles Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Yankees Orioles First Team to Score 9/21/25 1:35pm EDT	-165 +130 Bet
Yankees Orioles Tie 1st Inning Winner 9/21/25 1:35pm EDT	+280 +320 -140 Bet
Yankees Orioles Tie First 3 Innings Winner 9/21/25 1:35pm EDT	+130 +154 +280 Bet
Yankees Orioles To Extra Innings 9/21/25 1:35pm EDT	Yes +775 No -1400 Bet
	BetMGM
Yankees Orioles 1st Team to Score Will Win 9/21/25 1:35pm EDT	Yes -250 No +190 Bet
Orioles Total Runs NYY at BAL 9/21/25 1:35pm EDT	3.5 o -125 3.5 u -105 Bet
Yankees Total Runs NYY at BAL 9/21/25 1:35pm EDT	4.5 o -110 4.5 u -118 Bet
Cam Schlittler Strikeouts Thrown NYY at BAL 9/21/25 1:35pm EDT	6.5 o +120 6.5 u -155 Bet
	BetMGM
Kyle Bradish Strikeouts Thrown NYY at BAL 9/21/25 1:35pm EDT	5.5 o -155 5.5 u +115 Bet

New York Yankees & Baltimore Orioles Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

New York Yankees World Series Odds

No World Series TM New York Yankees YR: futures available

Baltimore Orioles World Series Odds

No World Series TM Baltimore Orioles YR: futures available

New York Yankees & Baltimore Orioles Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - New York Yankees, Baltimore Orioles
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - New York Yankees	94	68	0.580	+3.0	50-31	44-37	849	685	+164	W8	9-1
e - Baltimore Orioles	75	87	0.463	+22.0	39-42	36-45	677	788	-111	L3	3-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the New York Yankees vs Baltimore Orioles MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 1:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the New York Yankees vs Baltimore Orioles Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the New York Yankees vs Baltimore Orioles Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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