Houston Astros vs Chicago White Sox Odds

The Astros will play the White Sox on Sunday, May 4th, 2025. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Houston Astros have a 92.67 power ranking. The power ranking for the Chicago White Sox is 86.00.
  • Visiting Houston Astros - The Houston Astros have a 6-8 record as a visiting team, ranking them 6th Overall for visiting team wins.
  • Home Chicago White Sox - The Chicago White Sox have a 6-11 record as a home team. They rank 10th for home team wins in the Overall standings.
  • Runs Scored - The Houston Astros currently stand 15th (128) Overall, with the Chicago White Sox ranking 19th (119) for runs scored.
  • Runs Allowed - The Houston Astros are 23rd (114) Overall for runs allowed. The Chicago White Sox stand 14th (144) for runs allowed.
  • Team Streaks - The Houston Astros won their last game. Meanwhile, the Chicago White Sox lost their last game.
  • Team Records - The Houston Astros have a 17-15 Overall record (3.0 GB American West Division), with the Chicago White Sox possessing a 9-24 Overall standing (11.5 GB American Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Astros be heading to Chicago to plunder the White Sox...

Houston be lookin' to add to their winnin' ways against the hapless White Sox...

Ye best be visitin' SportsBetting3.com to bet on this game, review the odds below!

Best Astros at White Sox Odds


Best Moneyline Betting Odds
Underdog

Chicago White Sox
Favorite

Houston Astros
The Houston Astros are the -180 moneyline favorite. Risk $180 to win $100 on the Houston Astros at BetMGM. The Chicago White Sox are the +145 underdog at BetMGM. Risk $100 to win $145 on the Chicago White Sox. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8.5 runs. Risk $105 to win $100. BetMGM has the best under line of 8.5 runs. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Chicago White Sox
Favorite

Houston Astros
The Houston Astros have a -1.5 -110 run line at BetMGM OH. They are the run line favorite in this matchup. The Chicago White Sox have a +1.5 -110 run line at BetMGM OH. The Chicago White Sox are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Houston Astros vs Chicago White Sox MLB game on Sunday, May 4th, 2025?

The Houston Astros are the -180 moneyline favorite at BetMGM and the Chicago White Sox are the +145 moneyline underdog at BetMGM.

What is the over-under total line for the Houston Astros vs Chicago White Sox MLB game on Sunday, May 4th, 2025?

The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the run line for the Houston Astros vs Chicago White Sox MLB game on Sunday, May 4th, 2025?

The Houston Astros are -1.5 -110 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -110 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Astros
White Sox
5/04/25 2:10pm EDT
-180+145
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • Chicago White Sox bettors risk $100 to win $145 at +145 odds. The implied probability for Chicago White Sox is 40.82%.
  • Houston Astros bettors risk $100 to win $55.56 at -180 odds. The implied probability for Houston Astros is 64.29%.

Houston Astros at Chicago White Sox Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Astros
White Sox
First Team to Score
5/04/25 2:10pm EDT
-200+155Bet
Astros
White Sox
Tie
1st Inning Winner
5/04/25 2:10pm EDT
+250+375-140Bet
Astros
White Sox
Tie
First 3 Innings Winner
5/04/25 2:10pm EDT
+110+195+270Bet
Astros
White Sox
To Extra Innings
5/04/25 2:10pm EDT
Yes +775No -1400Bet
BetMGM Sports Betting BetMGM

Houston Astros & Chicago White Sox Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds
2025 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM
Astros
+2200
Bet
Chicago White Sox World Series Odds
2025 Chicago White Sox World Series Odds

Team
BetMGM Sports Betting BetMGM
White Sox
+100000
Bet

Houston Astros & Chicago White Sox Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Houston Astros, Chicago White Sox
Team W L Pct GB Home Away RS RA Diff Strk L10
Houston Astros28250.528+6.518-1010-15214190+24W26-4
Chicago White Sox17370.315+18.012-155-22183234-51L23-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs Chicago White Sox MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, May 4th, 2025 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Houston Astros vs Chicago White Sox Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Chicago White Sox Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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